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The role of extra centrosomes on the tumour microenvironment

Project description

Do centrosomes affect the tumour microenvironment?

Centrosomes promote cell division by facilitating the formation of mitotic spindles where chromosome segregation takes place. Abnormalities in the structure or number of centrosomes have been known for years to result in tumourigenesis. The EU-funded CentrosoTME project is investigating the hypothesis that cancer cells with aberrant centrosomes secrete extracellular vesicles that affect the tumour microenvironment. Researchers will analyse the factors secreted by cells with extra centrosomes and study the phenotypic impact they have on the tumour microenvironment. Given the active role of the tumour microenvironment in cancer progression, results have important consequences for cancer treatment.

Coordinator

QUEEN MARY UNIVERSITY OF LONDON
Net EU contribution
€ 212 933,76
Address
327 Mile End Road
E1 4NS London
United Kingdom

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Region
London Inner London — East Tower Hamlets
Activity type
Higher or Secondary Education Establishments
Other funding
€ 212 933,76