Project description
An automated microfluidic platform to screen ligands
Effective diagnostic technologies are essential for mitigating the devastating impact of infectious diseases. Identifying ligands that can target infectious disease biomarkers in patient samples is key to the function of modern diagnostics. However, current methods for ligand selection are slow and labour-intensive. Novel methods for automating ligand selection should increase the efficiency and capacity of communities to respond to disease outbreaks. The EU-funded microPhage project plans to develop a novel microfluidic device that could automate high-throughput ligand screening and apply it to generate novel ligands against an emerging HIV biomarker. The project will also explore novel microfluidic materials compatible with common ligand selection workflows.
Objective
Effective diagnostic technologies are essential for mitigating the devastating impact that infectious disease has on society. The identification of ligands that can target infectious disease biomarkers within patient samples is key to the function of modern diagnostics. Unfortunately, current methods for ligand selection are slow and labour intensive, and frequently hinder the development of diagnostic technologies. Novel methods for automating this process will increase efficiency and improve the capacity of communities to respond to outbreaks and epidemics. During this fellowship I will develop a novel microfluidic device capable of automated high-throughput selection of highly robust infectious disease targeting ligands. The main objectives are as follows: 1) Explore novel microfluidic materials that are compatible with common ligand selection work flows; 2) Develop a fully automated microfluidic platform capable of performing multiple rounds of ligand selection; 3) Apply this system to generate novel ligands against an emerging HIV biomarker. The device will be underpinned by multiple core microfluidic technologies developed within the host lab, including: rapid droplet generation, droplet disruption, non-fouling materials, and highly responsive microvalves. These technologies will be combined with my expertise in protein chemistry, protein engineering, and chemical biology to achieve a significant leap forwards in automated ligand selection. The resultant device will vastly increase accessibility to high-throughput ligand selection, enabling smaller labs to more effectively select high-affinity ligands against emerging disease targets. This will have a significant impact on the fields of diagnostics, targeted therapeutics, protein engineering, and microfluidics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences classical mechanics fluid mechanics microfluidics
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- engineering and technology medical engineering medical laboratory technology diagnostic technologies
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8092 Zuerich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.