Using human tissue to translate microRNA-based therapies for epilepsy

Project Information

EpimiRTherapy

Grant agreement ID: 840262

DOI 10.3030/840262

Project closed

EC signature date 10 April 2019

Start date 1 December 2019

End date 30 November 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 184 590,72

EU contribution € 184 590,72

Coordinated by

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

Publications

Peer reviewed articles (7)

Increased expression of the ATP-gated P2X7 receptor reduces responsiveness to anti-convulsants during status epilepticus in mice

Author(s): E Beamer, J Morgan, M Alves, A Mendez, G Morris, B Zimmer, G Conte, L de Diego-Garcia, C Alarcon-Vila, N Ng, S Madden, F Calzaferri, C de los Rios, A Garcia, M Hamacher, K Dinkel, P Pelegrin, D Henshall, A Nicke, T Engel
Published in: BJP, 2021, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.15785

Opportunities and challenges for microRNA-targeting therapeutics for epilepsy

Author(s): Gareth Morris, Denis O’Brien, David C. Henshall
Published in: Trends in Pharmacological Sciences, Issue 42/7, 2021, Page(s) 605-616, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2021.04.007

Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice

Author(s): Aoife Campbell, Gareth Morris, Janosch P. Heller, Elena Langa, Elizabeth Brindley, Jesper Worm, Mads Aaboe Jensen, Meghan T. Miller, David C. Henshall, Cristina R. Reschke
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-79350-7

A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy

Author(s): Morten T. Venø, Cristina R. Reschke, Gareth Morris, Niamh M. C. Connolly, Junyi Su, Yan Yan, Tobias Engel, Eva M. Jimenez-Mateos, Lea M. Harder, Dennis Pultz, Stefan J. Haunsberger, Ajay Pal, Janosch P. Heller, Aoife Campbell, Elena Langa, Gary P. Brennan, Karen Conboy, Amy Richardson, Braxton A. Norwood, Lara S. Costard, Valentin Neubert, Federico Del Gallo, Beatrice Salvetti, Vamshidhar R. Vang
Published in: Proceedings of the National Academy of Sciences, Issue 117/27, 2020, Page(s) 15977-15988, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1919313117

Limitations of animal epilepsy research models: Can epileptic human tissue provide translational benefit?

Author(s): Gareth Morris
Published in: ALTEX, 2021, ISSN 1868-596X
Publisher: Springer Spektrum
DOI: 10.14573/altex.2007082

BICS01 Mediates Reversible Anti-seizure Effects in Brain Slice Models of Epilepsy

Author(s): G Morris, M Heiland, K Lamottke, H Guan, T Hill, Y Zhou, Q Zhu, S Schorge, D Henshall
Published in: Frontiers in Neurology, 2022, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.791608

Detection of spontaneous seizures in EEGs in multiple experimental mouse models of epilepsy

Author(s): L Wei, H Boutouil, R Gerbatin, O Mamad, M Heiland, C Reschke, F Del Gallo, P Fabene, D Henshall, M Lowery, G Morris, C Mooney
Published in: Journal of Neural Engineering, Issue Oct 2021 18 (5), 2021, ISSN 1741-2552
Publisher: IOP
DOI: 10.1088/1741-2552/ac2ca0