Using human tissue to translate microRNA-based therapies for epilepsy

Informazioni relative al progetto

EpimiRTherapy

ID dell’accordo di sovvenzione: 840262

DOI 10.3030/840262

Progetto chiuso

Data della firma CE 10 Aprile 2019

Data di avvio 1 Dicembre 2019

Data di completamento 30 Novembre 2021

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale € 184 590,72

Contributo UE € 184 590,72

Coordinato da

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

Pubblicazioni

Peer reviewed articles (7)

Increased expression of the ATP-gated P2X7 receptor reduces responsiveness to anti-convulsants during status epilepticus in mice

Autori: E Beamer, J Morgan, M Alves, A Mendez, G Morris, B Zimmer, G Conte, L de Diego-Garcia, C Alarcon-Vila, N Ng, S Madden, F Calzaferri, C de los Rios, A Garcia, M Hamacher, K Dinkel, P Pelegrin, D Henshall, A Nicke, T Engel
Pubblicato in: BJP, 2021, ISSN 0007-1188
Editore: Wiley-Blackwell
DOI: 10.1111/bph.15785

Opportunities and challenges for microRNA-targeting therapeutics for epilepsy

Autori: Gareth Morris, Denis O’Brien, David C. Henshall
Pubblicato in: Trends in Pharmacological Sciences, Numero 42/7, 2021, Pagina/e 605-616, ISSN 0165-6147
Editore: Elsevier BV
DOI: 10.1016/j.tips.2021.04.007

Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice

Autori: Aoife Campbell, Gareth Morris, Janosch P. Heller, Elena Langa, Elizabeth Brindley, Jesper Worm, Mads Aaboe Jensen, Meghan T. Miller, David C. Henshall, Cristina R. Reschke
Pubblicato in: Scientific Reports, Numero 11/1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-79350-7

A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy

Autori: Morten T. Venø, Cristina R. Reschke, Gareth Morris, Niamh M. C. Connolly, Junyi Su, Yan Yan, Tobias Engel, Eva M. Jimenez-Mateos, Lea M. Harder, Dennis Pultz, Stefan J. Haunsberger, Ajay Pal, Janosch P. Heller, Aoife Campbell, Elena Langa, Gary P. Brennan, Karen Conboy, Amy Richardson, Braxton A. Norwood, Lara S. Costard, Valentin Neubert, Federico Del Gallo, Beatrice Salvetti, Vamshidhar R. Vang
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 117/27, 2020, Pagina/e 15977-15988, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1919313117

Limitations of animal epilepsy research models: Can epileptic human tissue provide translational benefit?

Autori: Gareth Morris
Pubblicato in: ALTEX, 2021, ISSN 1868-596X
Editore: Springer Spektrum
DOI: 10.14573/altex.2007082

BICS01 Mediates Reversible Anti-seizure Effects in Brain Slice Models of Epilepsy

Autori: G Morris, M Heiland, K Lamottke, H Guan, T Hill, Y Zhou, Q Zhu, S Schorge, D Henshall
Pubblicato in: Frontiers in Neurology, 2022, ISSN 1664-2295
Editore: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.791608

Detection of spontaneous seizures in EEGs in multiple experimental mouse models of epilepsy

Autori: L Wei, H Boutouil, R Gerbatin, O Mamad, M Heiland, C Reschke, F Del Gallo, P Fabene, D Henshall, M Lowery, G Morris, C Mooney
Pubblicato in: Journal of Neural Engineering, Numero Oct 2021 18 (5), 2021, ISSN 1741-2552
Editore: IOP
DOI: 10.1088/1741-2552/ac2ca0