Using human tissue to translate microRNA-based therapies for epilepsy

Información del proyecto

EpimiRTherapy

Identificador del acuerdo de subvención: 840262

DOI 10.3030/840262

Proyecto cerrado

Fecha de la firma de la CE 10 Abril 2019

Fecha de inicio 1 Diciembre 2019

Fecha de finalización 30 Noviembre 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total € 184 590,72

Aportación de la UE € 184 590,72

Coordinado por

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

Publicaciones

Peer reviewed articles (7)

Increased expression of the ATP-gated P2X7 receptor reduces responsiveness to anti-convulsants during status epilepticus in mice

Autores: E Beamer, J Morgan, M Alves, A Mendez, G Morris, B Zimmer, G Conte, L de Diego-Garcia, C Alarcon-Vila, N Ng, S Madden, F Calzaferri, C de los Rios, A Garcia, M Hamacher, K Dinkel, P Pelegrin, D Henshall, A Nicke, T Engel
Publicado en: BJP, 2021, ISSN 0007-1188
Editor: Wiley-Blackwell
DOI: 10.1111/bph.15785

Opportunities and challenges for microRNA-targeting therapeutics for epilepsy

Autores: Gareth Morris, Denis O’Brien, David C. Henshall
Publicado en: Trends in Pharmacological Sciences, Edición 42/7, 2021, Página(s) 605-616, ISSN 0165-6147
Editor: Elsevier BV
DOI: 10.1016/j.tips.2021.04.007

Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice

Autores: Aoife Campbell, Gareth Morris, Janosch P. Heller, Elena Langa, Elizabeth Brindley, Jesper Worm, Mads Aaboe Jensen, Meghan T. Miller, David C. Henshall, Cristina R. Reschke
Publicado en: Scientific Reports, Edición 11/1, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-79350-7

A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy

Autores: Morten T. Venø, Cristina R. Reschke, Gareth Morris, Niamh M. C. Connolly, Junyi Su, Yan Yan, Tobias Engel, Eva M. Jimenez-Mateos, Lea M. Harder, Dennis Pultz, Stefan J. Haunsberger, Ajay Pal, Janosch P. Heller, Aoife Campbell, Elena Langa, Gary P. Brennan, Karen Conboy, Amy Richardson, Braxton A. Norwood, Lara S. Costard, Valentin Neubert, Federico Del Gallo, Beatrice Salvetti, Vamshidhar R. Vang
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/27, 2020, Página(s) 15977-15988, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1919313117

Limitations of animal epilepsy research models: Can epileptic human tissue provide translational benefit?

Autores: Gareth Morris
Publicado en: ALTEX, 2021, ISSN 1868-596X
Editor: Springer Spektrum
DOI: 10.14573/altex.2007082

BICS01 Mediates Reversible Anti-seizure Effects in Brain Slice Models of Epilepsy

Autores: G Morris, M Heiland, K Lamottke, H Guan, T Hill, Y Zhou, Q Zhu, S Schorge, D Henshall
Publicado en: Frontiers in Neurology, 2022, ISSN 1664-2295
Editor: Frontiers Research Foundation
DOI: 10.3389/fneur.2021.791608

Detection of spontaneous seizures in EEGs in multiple experimental mouse models of epilepsy

Autores: L Wei, H Boutouil, R Gerbatin, O Mamad, M Heiland, C Reschke, F Del Gallo, P Fabene, D Henshall, M Lowery, G Morris, C Mooney
Publicado en: Journal of Neural Engineering, Edición Oct 2021 18 (5), 2021, ISSN 1741-2552
Editor: IOP
DOI: 10.1088/1741-2552/ac2ca0