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Uncovering molecular mechanisms of active transcriptional repression.

Project description

Dissecting the process of transcriptional repression

Accurate regulation of gene expression is central to all biological processes, including development. Silencing of transcription is mediated by proteins known as repressors. Despite their importance for gene expression, development and disease, their mechanism of action remains poorly understood. The EU-funded UMMATR project will decipher the specificity of transcriptional repressors and their capacity to act on selective promoters or genome-wide. Scientists will develop an inducible system of transcriptional silencing that will uncover key components and molecular events of the transcription process. The project will provide insight into gene expression regulation with significant ramifications for many diseases, including cancer.

Coordinator

FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH
Net EU contribution
€ 174 167,04
Address
Campus-vienna-biocenter 1
1030 Wien
Austria

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Region
Wien Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00