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Transient micromachined pressure-monitoring implants for chronic brain disorders

Project description

Timely micromachined-enabled prevention saving brains

Millions of people suffer from chronic brain disorders resulting from conditions such as strokes, trauma, and degenerative illnesses. Treatment costs hundreds of billions of euros, mostly due to lack of possibilities of timely reaction enabling prevention of further brain degeneration. Innovative solutions are required for effective brain monitoring in patients with chronic brain disorders. The EU-funded BrainWatch project aims to use micromachining technologies to design, build and define the first transient micromachined pressure monitoring implants enabling wireless communication in case of brain disorders. The project will combine micromachining with the outstanding properties of biodegradable materials for safe application to offer well adapted personalised monitoring out of hospital facilities for a preventative treatment.

Objective

Millions of people worldwide are living with chronic brain disorder causing direct and indirect cost of 100s of billion euros for health budgets. Majority of this cost incurs during the treatment and can be eliminated by developing tools to monitor critical parameters after patients are discharged from hospital settings. Because of the absence of such technology, abnormal changes cannot be detected until the opportunity to prevent further damage to the brain has passed. Recently developments in micromachining and biodegradable materials have revolutionized sensor and drug delivery/stent industry. Advances in micromachining can be combined with the unique features of biodegradable materials to realize transient implants that do not pose infection or inflammation risk and does not require an extraction surgery. The objective of this proposal is to design, fabricate and characterize transient micromachined pressure monitoring implants capable of wireless communication for brain disorders. This technology will allow continuous monitoring outside hospital settings and development of personalized and preventative treatments which aligns with the Horizon2020 health goal of providing more effective and timely therapies. Combining biodegradability to micromachined sensors comes with challenges and limitations in design, fabrication and integration, which this proposal aims to overcome with novel approaches. Dr. Levent Beker’s expertise in micromachined and flexible sensor development combined with the expertise of the supervisor and collaborators in nano-patterning, biodegradable materials, wireless communication and neurosurgery will help to accomplish goals of the proposal. This two-year fellowship at Koc University, TR with, a secondment at ETH Zurich, CH, will help Dr. Beker to expand his scientific skill sets, develop research management skills to become an independent researcher while effectively transferring experience to host institutions.

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Programme(s)

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Topic(s)

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Funding Scheme

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MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-IF-2018

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Coordinator

KOC UNIVERSITY
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 157 355,52
Address
RUMELI FENERI YOLU SARIYER
34450 Istanbul
Türkiye

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Region
İstanbul İstanbul İstanbul
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 157 355,52
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