Transient micromachined pressure-monitoring implants for chronic brain disorders

Projektbeschreibung

Wie frühzeitige mikromechanikgestützte Prävention Gehirne rettet

Millionen Menschen leiden an durch Schlaganfälle, Traumata und degenerative Erkrankungen verursachten chronischen Hirnstörungen. Behandlungen kosten hunderte Milliarden Euro, und das vor allem, weil es keine Möglichkeit gibt, rechtzeitig zu reagieren und weitere Schäden am Gehirn zu verhindern. Zur wirkungsvollen Überwachung des Gehirns der von chronischen Hirnerkrankungen Betroffenen sind innovative Lösungen erforderlich. Ziel des EU-finanzierten Projekts BrainWatch ist der Einsatz von Mikromechaniktechnologien, um erste mikrobearbeitete Implantate zur Überwachung des transienten Drucks zu entwerfen, zu bauen und zu definieren, die im Fall von Hirnstörungen eine drahtlose Kommunikation gestatten. Das Projekt wird die Mikromechanik mit den herausragenden Eigenschaften biologisch abbaubarer Materialien in Form einer sicheren Anwendung kombinieren, um eine gut angepasste personalisierte Überwachung außerhalb des Krankenhauses im Sinne einer präventiven Behandlung anzubieten.

Ziel

Millions of people worldwide are living with chronic brain disorder causing direct and indirect cost of 100s of billion euros for health budgets. Majority of this cost incurs during the treatment and can be eliminated by developing tools to monitor critical parameters after patients are discharged from hospital settings. Because of the absence of such technology, abnormal changes cannot be detected until the opportunity to prevent further damage to the brain has passed. Recently developments in micromachining and biodegradable materials have revolutionized sensor and drug delivery/stent industry. Advances in micromachining can be combined with the unique features of biodegradable materials to realize transient implants that do not pose infection or inflammation risk and does not require an extraction surgery. The objective of this proposal is to design, fabricate and characterize transient micromachined pressure monitoring implants capable of wireless communication for brain disorders. This technology will allow continuous monitoring outside hospital settings and development of personalized and preventative treatments which aligns with the Horizon2020 health goal of providing more effective and timely therapies. Combining biodegradability to micromachined sensors comes with challenges and limitations in design, fabrication and integration, which this proposal aims to overcome with novel approaches. Dr. Levent Beker’s expertise in micromachined and flexible sensor development combined with the expertise of the supervisor and collaborators in nano-patterning, biodegradable materials, wireless communication and neurosurgery will help to accomplish goals of the proposal. This two-year fellowship at Koc University, TR with, a secondment at ETH Zurich, CH, will help Dr. Beker to expand his scientific skill sets, develop research management skills to become an independent researcher while effectively transferring experience to host institutions.