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Proof-of-Concept of a nanobody targeting Osteopontin to inhibit colorectal cancer development

Objective

In this ERC Proof-of-Concept project, we aim to demonstrate the technical and commercial feasibility of a nanobody to target Osteopontin (OPN) for (co)treatment of colorectal cancer (CRC). This proposed project builds further upon recent findings as part of the ERC CRCStemCellDynamics project, in which we showed that OPN plays an important role in clonal expansion and cancer stem cell functionality.

CRC accounts for ~10% of all cancers worldwide and forms a heavy financial burden for the EU healthcare system. The 5-year survival rate for patients with CRC is < 60% and for metastatic CRC (mCRC) patients even < 20%. Over the last 15 years, treatment options for CRC have been static and new therapies for CRC are urgently needed.

Findings from our lab indicates that a nanobody to block OPN would be an attractive approach for CRC (co)treatment. In this project we will 1) generate a therapeutic nanobody together with key experts in the field, 2) demonstrate efficacy of the nanobody in human CRC xenograft models, 3) compile a “data package” to attract partners for further financing towards commercialisation, 4) establish a solid business plan, including intellectual property (IP) protection, a market/competitor analysis and an exploitation plan, and 5) set up collaborations with pharmaceutical partners for (co)development and/or a licensing deal.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /social sciences/economics and business
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/colorectal cancer

Call for proposal

ERC-2018-PoC
See other projects for this call

Funding Scheme

ERC-POC - Proof of Concept Grant

Host institution

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Address
Meibergdreef 15
1105AZ Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 149 953,75

Beneficiaries (1)

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 149 953,75
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments