Project description
Lights, camera, action: watching dynamic molecular interactions in motion
Chirality is an interesting property of many biological molecules in which the mirror images – the same atoms attached to the same places – cannot be superimposed. Human hands are an example of this – mirror images in which the pinkie gets superimposed on the thumb when you put one hand on top of the other. Polarised light can probe chiral molecules with great structural sensitivity, and it is widely used to study biologically important molecules such as proteins, nucleic acids, carbohydrates and drugs. The EU-funded CHIRALSCOPY project is combining this highly sensitive structural probing technique with ultrafast optical spectroscopy to enable "movies" of structural changes during chemical reactions and biological processes.
Objective
Since the structure of a (bio)-molecule is crucially linked to its biochemical functions, following its evolution in the course of a chemical reaction or biological process would allow one to gain fundamental insights into the reaction mechanisms and pathways. This calls for optical spectroscopy techniques capable of recording structural dynamics with high time resolution, down to the femtosecond regime. Circular dichroism (CD), i.e. the difference in absorption of left- and right-handed circularly polarised light, is a sensitive probe of the structure of chiral molecules. CHIRALSCOPY aims to develop an innovative time-resolved CD spectrometer which combines the structural sensitivity of steady-state CD spectroscopy with the high time resolution of ultrafast nonlinear optical spectroscopy. CHIRALSCOPY will adopt an innovative approach which directly measures in the time domain the chiral light field from a molecule by combining interferometric detection with optical heterodyne amplification. The state-of-the-art time-resolved CD instrument will be used to elucidate structural dynamics during a prototypical biochemical reaction. CHIRALSCOPY will equip the Experienced Researcher with new knowledge and skills in advanced optical technologies and biophysics, thus broadening his scientific background and enhancing his prospects as an independent researcher. At the same time, the Action and the Host Institution will benefit from the advanced knowledge in ultrafast spectroscopy acquired by Researcher during his PhD thesis. CHIRALSCOPY promises to open new vistas in the field of ultrafast optical spectroscopy enabling one to interrogate molecular dynamics with femtosecond temporal resolution and exquisite structural sensitivity−thus realising the chemist’s dream of a capturing a ‘molecular-motion-picture’ of a chemical reaction.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biophysics
- natural sciences chemical sciences
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20133 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.