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Targeting integrin signaling in tumour-associated macrophages to combat cancer progression and resistance

Project description

Inhibition of tumour-associated macrophages as an anti-cancer treatment

Infiltration of tumour-associated macrophages (TAMs) is linked to poor cancer prognosis. Recent evidence indicates that inhibition of TAM migration reduces tumour infiltration and halts cancer progression in animal models. The EU-funded MacrophInt project proposes to target integrin signalling in TAMs as a new strategy to manipulate their infiltration into tumours. Integrins are central to the mesenchymal migratory mode of TAMs, which involves the adherence of cell podosomes to the surrounding extracellular matrix. Inhibition of TAM migration could be employed in conjunction with other anti-cancer strategies to improve patient clinical outcome.

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Net EU contribution
€ 116 953,92
Address
Rue Michel Ange 3
75794 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00