Targeting integrin signaling in tumour-associated macrophages to combat cancer progression and resistance

Project description

Inhibition of tumour-associated macrophages as an anti-cancer treatment

Infiltration of tumour-associated macrophages (TAMs) is linked to poor cancer prognosis. Recent evidence indicates that inhibition of TAM migration reduces tumour infiltration and halts cancer progression in animal models. The EU-funded MacrophInt project proposes to target integrin signalling in TAMs as a new strategy to manipulate their infiltration into tumours. Integrins are central to the mesenchymal migratory mode of TAMs, which involves the adherence of cell podosomes to the surrounding extracellular matrix. Inhibition of TAM migration could be employed in conjunction with other anti-cancer strategies to improve patient clinical outcome.

Fields of science

• medical and health sciences › clinical medicine › oncology
• medical and health sciences › basic medicine › physiology › homeostasis

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

See other projects for this call

Funding Scheme

MSCA-IF-EF-RI - RI – Reintegration panel

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Net EU contribution

€ 116 953,92

Address

Rue Michel Ange 3
75794 Paris
France

Region

Ile-de-France › Ile-de-France › Paris

Activity type

Research Organisations

Links

Other funding

€ 0,00