Inhibition of tumour-associated macrophages as an anti-cancer treatment
Infiltration of tumour-associated macrophages (TAMs) is linked to poor cancer prognosis. Recent evidence indicates that inhibition of TAM migration reduces tumour infiltration and halts cancer progression in animal models. The EU-funded MacrophInt project proposes to target integrin signalling in TAMs as a new strategy to manipulate their infiltration into tumours. Integrins are central to the mesenchymal migratory mode of TAMs, which involves the adherence of cell podosomes to the surrounding extracellular matrix. Inhibition of TAM migration could be employed in conjunction with other anti-cancer strategies to improve patient clinical outcome.