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Challenging the KNDy Hypothesis Using CRISPR-Cas9 Genome Editing: Evaluation of the Role of Neurokinin B and Dynorphin in Kiss1 neurons in the Control of Fertility

Project description

Insight into neuroendocrine control of fertility

Reproductive activity in animals and humans is maintained by the hypothalamic–pituitary–gonadal (HPG) axis. The hypothalamus secretes gonadotropin-releasing hormone (GnRH), which regulates secretion of luteinising hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. Both LH and FSH are necessary for ovary stimulation and fertility. The scope of the EU-funded CRISPR-KissCas9 project is to understand the regulation of pulsatile GnRH release. Researchers will focus on specific neuropeptides expressed by neuronal cells in the hypothalamus and investigate their physiological roles. Results will provide important information on the neuroendocrine mechanisms that control fertility, laying the foundation for improved treatments against infertility.


Net EU contribution
€ 160 932,48
Avenida De Medina Azahara 5
14005 Cordoba

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Andalucía Córdoba
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00