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Inhibiting tumor cell plasticity by targeting the epigenome in breast cancer

Project description

Novel epigenetic targets in breast cancer

One of the hallmarks of cancer is heterogeneity, the presence of subpopulations of cells with distinct morphological, phenotypic and genotypic profiles. Although this affects the efficacy of anti-cancer therapeutics, the underlying aetiology is poorly defined. The EU-funded EPICAN project focuses on the phosphoinositide 3-kinase (PI3K) pathway, a signal transduction system implicated in many essential cell functions as well as in oncogenesis. The working hypothesis is that PI3K oncogenic mutations reactivate multipotency in mammary cells, leading to tumour plasticity and heterogeneity. Identification of epigenetic regulators that function downstream of the PI3K pathway has the potential to lead to new therapeutic targets.

Coordinator

UNIVERSITAT BASEL
Net EU contribution
€ 191 149,44
Address
Petersplatz 1
4051 Basel
Switzerland

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00