Description du projet
Une nouvelle référence absolue en matière de catalyseurs pour les transformations connues et les nouvelles réactivités
La chimie de synthèse joue un rôle essentiel dans la synthèse des composés naturels d’intérêt commercial et dans la synthèse de molécules nouvelles et personnalisées avec des fonctions spécifiques. Les chimistes utilisent des éléments constitutifs au sein desquels ils peuvent rompre des liaisons, retirer certains groupes et en ajouter d’autres, un peu comme un enfant qui joue avec des Lego. Toutefois, contrairement à ces «transformations» simples, la rupture et la création de liaisons font souvent appel à la catalyse. Le projet Au-MLC, financé par l’UE, va étudier un processus catalytique prometteur, mais encore inexploré, exploitant la capacité avérée de l’or à favoriser les transformations chimiques. L’équipe développera plusieurs catalyseurs et mettra en évidence leur utilisation dans de nouvelles réactions séquentielles.
Objectif
Gold catalysis has gathered increasing attention from the synthetic community during the last decades, due to the remarkable ability of Au centres to promote chemical transformations. Typically, gold catalysis is based on its peculiar properties as a Lewis acid, that make it very well suited for the activation of unsaturated bonds. On the other hand, the use of gold in more sophisticated processes, such as cooperative catalysis, is at its pioneering stage, and only few examples of these strategies are currently known. Metal-Ligand Cooperation strategies (MLC) are an emerging tool in homogeneous catalysis, based on the interplay between the metal centre and the non-innocent (bifunctional) ligand. This synergy vastly enhances the performances of known transformations, and even enables new sets of reactivities. MLC has been applied to many metal centres, often with spectacular results; Au-MLC strategies, however, are unknown to date. This project focuses on the development of a family of novel Au(III) complexes bearing Brønsted basic, non-innocent pincer ligands characteristics. Their fundamental study will be performed, assessing their Lewis acidity (especially in the Pearson HSAB scale), their Brønsted basicity, and their stoichiometric interaction with X–H bonds. Based on these results, their use as bifunctional Lewis-acid catalysts will be explored for the electrophilic activation of alkynes, carbonyl compounds, and alcohols. The design and development of sequential reactions involving the bifunctional gold catalysts obtained in the context of this project will be the ultimate, most ambitious goal of this action.
Champ scientifique
Programme(s)
Régime de financement
MSCA-IF-EF-ST - Standard EFCoordinateur
75794 Paris
France