Project description
Genetic insight into the onset of childhood neurodevelopmental disorders
The EU-funded GRASAD project is investigating the genetic and evolutionary aspects of autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD), which have an onset in childhood. The aim is to understand the common ground between and high prevalence of these neurodevelopmental disorders. Researchers will identify adverse genetic risk factors and common symptoms and elucidate the aetiology of ASD and ADHD. Apart from fundamental knowledge on the roots of these two disorders, the project has the potential to generate new hypotheses and guide future research towards a personalised medicine approach.
Objective
Autism Spectrum Disorders (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are common neurodevelopmental and childhood-onset chronic disorders. Although ASD and ADHD do have distinct diagnostic definitions, evidence has accumulated to suggest substantial overlap between their symptoms. Despite of being notably impairing and presenting deleterious effects on reproductive success they both are highly prevalent. The goal of GRASAD is the study of two important remaining unsolved issues regarding the genetic underpinnings of ASD and ADHD taking advantage of the most innovative approaches in the neurogenetics field. On one side, GRASAD-I will apply state-of-the-art methodologies to address the question of which and how a diverse set of genetic risk factors are involved in both ASD and ADHD and subsequently to specific symptoms shared between both disorders. On the other side, GRASAD-II will study evolutionary aspects of the genetic roots of ASD from a genomics perspective to shed light on the so-called paradox of psychiatric disorders: given that these disorders are considered maladaptive and have heritable risk, why do they still exist? This study is relevant due to it will not only pave the way for a more precise scientific understanding of ASD and its overlap with ADHD but also can have an impact on psychiatric practice within a precision medicine framework. The evolutionary perspective of the project can generate new hypotheses and guide research, inform treatment strategies, provide a more natural view of disease and elucidate the aetiology of mental illness and suffering. The multidisciplinary nature of the project is strong, involving a combination of well-developed novel approaches in the field of psychiatric genetics. This proposal includes both the transfer of knowledge to the host institution and the training of the candidate in new methodologies. This project is line with the EU strategy on Mental Health and Well Being.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- medical and health sciences clinical medicine psychiatry
- medical and health sciences health sciences personalized medicine
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
08007 BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.