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Uncovering the genetic roots of ASD and ADHD

Description du projet

Un aperçu génétique de l’apparition des troubles du neurodéveloppement chez les enfants

Le projet GRASAD, financé par l’UE, examine les aspects génétiques et évolutifs des troubles du spectre autistique (TSA) et du déficit de l’attention avec ou sans hyperactivité (TDAH), qui apparaissent à l’enfance. L’objectif est de comprendre la base commune et la prévalence élevée de ces troubles du neurodéveloppement. Les chercheurs identifieront les facteurs de risque génétiques défavorables et les symptômes communs, et détermineront l’étiologie des TSA et du TDAH. En plus des connaissances fondamentales sur les racines de ces deux troubles, le projet entend générer de nouvelles hypothèses et orienter la future recherche vers une approche médicale personnalisée.

Objectif

Autism Spectrum Disorders (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are common neurodevelopmental and childhood-onset chronic disorders. Although ASD and ADHD do have distinct diagnostic definitions, evidence has accumulated to suggest substantial overlap between their symptoms. Despite of being notably impairing and presenting deleterious effects on reproductive success they both are highly prevalent. The goal of GRASAD is the study of two important remaining unsolved issues regarding the genetic underpinnings of ASD and ADHD taking advantage of the most innovative approaches in the neurogenetics field. On one side, GRASAD-I will apply state-of-the-art methodologies to address the question of which and how a diverse set of genetic risk factors are involved in both ASD and ADHD and subsequently to specific symptoms shared between both disorders. On the other side, GRASAD-II will study evolutionary aspects of the genetic roots of ASD from a genomics perspective to shed light on the so-called paradox of psychiatric disorders: given that these disorders are considered maladaptive and have heritable risk, why do they still exist? This study is relevant due to it will not only pave the way for a more precise scientific understanding of ASD and its overlap with ADHD but also can have an impact on psychiatric practice within a precision medicine framework. The evolutionary perspective of the project can generate new hypotheses and guide research, inform treatment strategies, provide a more natural view of disease and elucidate the aetiology of mental illness and suffering. The multidisciplinary nature of the project is strong, involving a combination of well-developed novel approaches in the field of psychiatric genetics. This proposal includes both the transfer of knowledge to the host institution and the training of the candidate in new methodologies. This project is line with the EU strategy on Mental Health and Well Being.

Champ scientifique (EuroSciVoc)

Mots‑clés

Programme(s)

Thème(s)

Régime de financement

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

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Appel à propositions

(s’ouvre dans une nouvelle fenêtre) H2020-MSCA-IF-2018

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Coordinateur

UNIVERSITAT DE BARCELONA
Contribution nette de l'UE
€ 160 932,48
Adresse
GRAN VIA DE LES CORTS CATALANES 585
08007 Barcelona
Espagne
Région
Este Cataluña Barcelona
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
€ 160 932,48