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De novo design of an UpConverting metalloProtein

Objective

Herein, we propose to design de novo (“from scratch”) the first upconverting metalloprotein. This will be achieved by exploiting a new class of lanthanide coiled coils (LCC), to generate bimetallic derivatives. These will, for the first time, combine the attractive photophysical properties of Ln complexes, with de novo designed coiled coil scaffolds capable of selectively binding different Ln ions at well-defined and tuneable distances. This programme of work will provide a new strategy for unlocking the full potential of science at the interface of biology and inorganic chemistry, by combining previously unexplored ligands with traditional inorganic complexes, for applications beyond those offered by biology, such as upconversion. The complementary expertise of Dr Borghesani (bioinorganic chemistry and spectroscopy) and the supervisor Dr Peacock (metallopeptide design) offer the unique combination to realise the full potential of multimetallic LCCs, and will, in conjunction with two planned short secondments, provide Dr Borghesani with new and cutting-edge research training.

Field of science

  • /natural sciences/chemical sciences/inorganic chemistry/bioinorganic chemistry
  • /natural sciences/chemical sciences/analytical chemistry/spectroscopy
  • /natural sciences/chemical sciences/inorganic chemistry

Call for proposal

H2020-MSCA-IF-2018
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

THE UNIVERSITY OF BIRMINGHAM
Address
Edgbaston
B15 2TT Birmingham
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 212 933,76