Project description
New class of metalloproteins tailored for upconversion luminescence
Upconversion, the process by which two photons are converted into a single one having higher energy, has been observed in few materials, most notably those doped with lanthanide ions. Funded by the Marie Skłodowska-Curie Actions programme, the UCLnProt project plans to design the first of their kind metalloproteins for upconversion. To this end, researchers will combine lanthanide complexes, which demonstrate excellent photophysical properties, with coiled coil scaffolds. These proteins, which are coiled together like the strands of a rope, can selectively bind to different lanthanide ions at defined locations and distances. Project work should help generate a new class of ligands, adding it to the toolbox of lanthanide coordination chemistry.
Objective
Herein, we propose to design de novo (“from scratch”) the first upconverting metalloprotein. This will be achieved by exploiting a new class of lanthanide coiled coils (LCC), to generate bimetallic derivatives. These will, for the first time, combine the attractive photophysical properties of Ln complexes, with de novo designed coiled coil scaffolds capable of selectively binding different Ln ions at well-defined and tuneable distances. This programme of work will provide a new strategy for unlocking the full potential of science at the interface of biology and inorganic chemistry, by combining previously unexplored ligands with traditional inorganic complexes, for applications beyond those offered by biology, such as upconversion. The complementary expertise of Dr Borghesani (bioinorganic chemistry and spectroscopy) and the supervisor Dr Peacock (metallopeptide design) offer the unique combination to realise the full potential of multimetallic LCCs, and will, in conjunction with two planned short secondments, provide Dr Borghesani with new and cutting-edge research training.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry bioinorganic chemistry
- natural sciences physical sciences quantum physics quantum optics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
B15 2TT Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.