Project description
Understanding the diversified ageing process
Despite the increasing developments in the biology of ageing, the diversity of people’s ageing trajectories remains an unexplored area. Aiming to a better understanding of the mechanisms of human ageing, the EU-funded REPRODAGEING project will bring together elements from evolutionary biology, behavioural ecology, ecophysiology and an innovative avian life-history model. The ecophysiological research project aims to quantify how divergent reproductive strategies influence individual, sex-specific and transgenerational ageing trajectories. Upon its completion, REPRODAGEING will provide significant data for the fields of fundamental evolutionary biology, biomedicine, assisted reproduction, animal breeding and wildlife conservation.
Objective
Understanding why we age and die, and why individuals differ in their ageing trajectories remains one of the big challenges for science. REPRODAGEING uses a combination of complementary approaches and cutting-edge techniques from evolutionary biology, behavioural ecology and ecophysiology and an innovative avian life history model – Japanese quail (Coturnix japonica) artificial selection lines that differ genetically in their pace of life – to quantify how divergent reproductive strategies influence individual, sex-specific and transgenerational ageing trajectories. I will use biomarkers of oxidative stress and ageing to quantify within-individual mosaics of physiological damage accumulation across somatic and reproductive tissues and test if these within-body mosaics of ageing are shaped by an individual’s life history strategy. Furthermore, I will quantify how parental physiological states at conception affect the next generation and if these transgenerational effects are shaped by the quality of the early life environment. I will be hosted at the Centre for Ecology & Conservation, University of Exeter, UK, which is one of the leading departments for evolutionary whole-organism research in Europe. The host complements my own research strengths in an ideal way, ensuring a successful implementation of the project, and allowing me to develop my research profile. At the same time, I will enhance the host’s expertise and capacity in ecophysiological research. Thus, this fellowship will enhance my skills and career prospects through a two-way transfer of knowledge. REPRODAGEING is highly relevant for fundamental evolutionary biology, but has also implications for biomedicine, assisted reproduction, animal breeding and wildlife conservation, and it will contribute to enhance the European science excellence and competitiveness.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology environmental engineering ecosystem-based management habitat conservation
- humanities history and archaeology history
- natural sciences biological sciences ecology
- natural sciences biological sciences evolutionary biology
- natural sciences biological sciences biological behavioural sciences behavioural ecology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
EX4 4QJ Exeter
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.