Insight into lymphoma formation in patients with coeliac disease
Coeliac disease (CD) is an autoimmune disease characterised by intolerance to gluten, a protein found in some grains. Lymphomas complicating CD are derived from a subset of gut innate lymphocytes that have acquired mutations in JAK1 and/or STAT3. Targeted JAK1-STAT3 blockade therefore emerges as a possible therapeutic option to eliminate tumour cells. Yet malignant cells, even at the early stage of lymphoproliferation, display additional mutations. The scope of the EU-funded SingCelCD project is to investigate how targeted therapies may be counter-productive due to the presence of refractory tumour subpopulations and could interfere with anti-tumour response. Results will help understand the onset of lymphoma and pave the way towards the identification of therapeutic targets.