Skip to main content

Single Cell approaches for the study of oncogenic processes during coeliac disease.

Project description

Insight into lymphoma formation in patients with coeliac disease

Coeliac disease (CD) is an autoimmune disease characterised by intolerance to gluten, a protein found in some grains. Lymphomas complicating CD are derived from a subset of gut innate lymphocytes that have acquired mutations in JAK1 and/or STAT3. Targeted JAK1-STAT3 blockade therefore emerges as a possible therapeutic option to eliminate tumour cells. Yet malignant cells, even at the early stage of lymphoproliferation, display additional mutations. The scope of the EU-funded SingCelCD project is to investigate how targeted therapies may be counter-productive due to the presence of refractory tumour subpopulations and could interfere with anti-tumour response. Results will help understand the onset of lymphoma and pave the way towards the identification of therapeutic targets.

Coordinator

IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION
Net EU contribution
€ 196 707,84
Address
24 Bd Du Montparnasse
75015 Paris 15
France

See on map

Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00