Tracing the link between mitochondrial morphology and acute myeloid leukaemia
Mitochondria are cell energy factories that are involved in the regulation of numerous biological processes. Recently, the host laboratory of the EU-funded Mitobetes project completed a proteomic study of protein associations in intact mitochondria cristae. Among different hits, they identified von Willebrand domain-containing protein 8 (Vwa8), a mitochondrial protein with unknown function whose higher levels correlate with worse prognosis of acute myeloid leukaemia (AML). During the Mitobetes project, the team aims to understand the role of Vwa8 in mitochondrial morphology and function. The objective is to find a link between mitochondrial morphology and AML. In addition, Mitobetes will study if this poorly characterised mitochondrial protein is involved in pathological processes associated with kidney failure and diabetes.
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