The role of Von Willebrand Domain-containing Protein 8 in mitochondrial physiology

Project description

Tracing the link between mitochondrial morphology and acute myeloid leukaemia

Mitochondria are cell energy factories that are involved in the regulation of numerous biological processes. Recently, the host laboratory of the EU-funded Mitobetes project completed a proteomic study of protein associations in intact mitochondria cristae. Among different hits, they identified von Willebrand domain-containing protein 8 (Vwa8), a mitochondrial protein with unknown function whose higher levels correlate with worse prognosis of acute myeloid leukaemia (AML). During the Mitobetes project, the team aims to understand the role of Vwa8 in mitochondrial morphology and function. The objective is to find a link between mitochondrial morphology and AML. In addition, Mitobetes will study if this poorly characterised mitochondrial protein is involved in pathological processes associated with kidney failure and diabetes.

Fields of science

• engineering and technology › environmental engineering › energy and fuels › energy conversion
• medical and health sciences › clinical medicine › endocrinology › diabetes
• natural sciences › biological sciences › biochemistry › biomolecules › proteins

Programme(s)

• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

UNIVERSITA DEGLI STUDI DI PADOVA

Address

Via 8 Febbraio 2
35122 Padova
Italy

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 183 473,28