Common mechanisms for decision-making and working memory in health and old age

Description du projet

Des similitudes entre la prise de décision et la mémoire de travail

De récents développements théoriques suggèrent que la prise de décision et la mémoire de travail pourraient découler des mêmes mécanismes neuronaux fondamentaux, alors que jusqu’à présent, ces deux types de fonctions cognitives ont été étudiés séparément. Le projet COMEDM, financé par l’UE, testera cette proposition pour la première fois. Il exploitera des outils de pointe du domaine des neurosciences humaines pour chercher des similitudes entre la prise de décision et la mémoire de travail, ainsi qu’une possible base neuronale commune afin d’expliquer les défauts de ces deux fonctions chez une grande partie de la population mondiale: les personnes âgées en bonne santé. La diffusion des résultats, l’expansion du réseau mondial de recherche de la personne boursière et l’ouverture d’une voie pour des perspectives de financement supérieur sont quelques-uns des objectifs du projet.

Objectif

We are constantly required to keep recently encountered information about the world in mind, and to use that information to make appropriate decisions. These essential cognitive functions, known as working memory (WM) and decision-making (DM), are conventionally studied in isolation by psychologists and neuroscientists. Yet, recent theoretical developments suggest that both DM and WM could emerge from the same fundamental neural mechanisms. With this Marie Skłodowska-Curie Fellowship, hosted by Trinity College Dublin and IDIBAPS Barcelona, I will empirically test this exciting proposal for the first time. In my career thus far, I have characterised new neural signatures of DM and established a non-invasive proxy for powerful neural systems linked to both DM and WM. Now, I will supplement these breakthroughs with a number of cutting-edge approaches in cognitive neuroscience specialised in by my host supervisors Prof. Robert Whelan and Dr. Albert Compte. This suite of tools will allow me to expose commonalities between DM and WM at an unprecedented level of detail, and interrogate a possible common neural basis for DM and WM deficits that exist in a large part of the global population – healthy elderly individuals. During my Fellowship, I will publish my findings in leading journals and work to communicate my research activities to the largest possible audience. I will participate in professional development programs to develop essential competencies in personnel management and grant writing, and will capitalise on my secondment in Barcelona to grow my global research network. Additionally, I will receive advanced training in sophisticated methodological and analytical approaches, which will continue my progression toward becoming a leading cognitive neuroscientist capable of competing for high-level funding opportunities. Thus, this Fellowship will prepare me well for a future career as the principle investigator of a multidisciplinary European research laboratory.