Common mechanisms for decision-making and working memory in health and old age

Projektbeschreibung

Gemeinsamkeiten zwischen Entscheidungen und Arbeitsgedächtnis

Jüngste theoretische Entwicklungen deuten darauf hin, dass dem Entscheidungsvorgang und dem Arbeitsgedächtnis dieselben grundlegenden neuronalen Mechanismen zugrunde liegen könnten. Das steht im Gegensatz zur bisherigen Annahme, die diese beiden Formen der kognitiven Funktion voneinander getrennt betrachtet. Das EU-finanzierte Projekt COMEDM wird diese neue Theorie nun erstmals untersuchen. Mithilfe innovativer Tools der humanen Neurowissenschaft will das Projekt Gemeinsamkeiten zwischen dem Entscheidungsvorgang und dem Arbeitsgedächtnis erforschen und nach einer möglichen gemeinsamen neuronalen Basis für Defekte beider Funktionen suchen, die bei einem wesentlichen Teil der Weltbevölkerung auftreten: gesunden, älteren Erwachsenen. Das Projekt soll unter anderem die gewonnenen Erkenntnisse verbreiten, das weltweite Forschungsnetzwerk des Stipendiaten ausbauen und den Weg für umfassendere Fördermöglichkeiten ebnen.

Ziel

We are constantly required to keep recently encountered information about the world in mind, and to use that information to make appropriate decisions. These essential cognitive functions, known as working memory (WM) and decision-making (DM), are conventionally studied in isolation by psychologists and neuroscientists. Yet, recent theoretical developments suggest that both DM and WM could emerge from the same fundamental neural mechanisms. With this Marie Skłodowska-Curie Fellowship, hosted by Trinity College Dublin and IDIBAPS Barcelona, I will empirically test this exciting proposal for the first time. In my career thus far, I have characterised new neural signatures of DM and established a non-invasive proxy for powerful neural systems linked to both DM and WM. Now, I will supplement these breakthroughs with a number of cutting-edge approaches in cognitive neuroscience specialised in by my host supervisors Prof. Robert Whelan and Dr. Albert Compte. This suite of tools will allow me to expose commonalities between DM and WM at an unprecedented level of detail, and interrogate a possible common neural basis for DM and WM deficits that exist in a large part of the global population – healthy elderly individuals. During my Fellowship, I will publish my findings in leading journals and work to communicate my research activities to the largest possible audience. I will participate in professional development programs to develop essential competencies in personnel management and grant writing, and will capitalise on my secondment in Barcelona to grow my global research network. Additionally, I will receive advanced training in sophisticated methodological and analytical approaches, which will continue my progression toward becoming a leading cognitive neuroscientist capable of competing for high-level funding opportunities. Thus, this Fellowship will prepare me well for a future career as the principle investigator of a multidisciplinary European research laboratory.