Reprogramming neuronal cells for brain regeneration
Neurogenesis in the adult brain is a very rare phenomenon, indicating that the regenerative capacity of the brain is limited. This has important consequences for the millions of individuals who suffer from neurological disorders. The EU-funded 4F4REJUVENGLIA project proposes an innovative rejuvenating approach to stimulate the regeneration of damaged areas of the brain. Using nuclear cell reprogramming technology, researchers will deliver four protein factors to parenchymal glia to revert cells back to neural progenitors that can give rise to new neurons. The aim is to increase the possibilities of recovering lost or damaged neurons and integrate them into the brain circuits.