Project description
Unravelling the role of inflammation in cardiovascular disease manifestation
Preventive therapies can stave off or delay the occurrence of cardiovascular disorders if individuals at risk are identified on time. Inflammation drives the development of cardiovascular disease, but routine screening of inflammatory markers to assess cardiovascular risk in the general population is not yet an option. The goal of the EU-funded INF-CVD project is to investigate the associations between a range of chronic inflammatory conditions and different types of cardiovascular disorders using one of the world's largest available longitudinal healthcare datasets. A better understanding of cardiovascular risks associated with chronic inflammation may help create guidelines and put the focus on patients at risk, for whom screening and treatment are likely to prevent the occurrence of the disease.
Objective
Cardiovascular disease is the leading cause of death and illness globally. Preventive therapies can avoid or delay the occurrence of cardiovascular events, provided that one can identify individuals at risk and intervene before problems manifest. Recent scientific developments have established that inflammation has a prominent role in the development of cardiovascular diseases; but routine screening of inflammatory markers to assess cardiovascular risk in the general population is currently unfeasible. It is known however that certain diseases cause high and chronic inflammation, and patients affected by these conditions may be at increased risk of cardiovascular events. Yet, studies so far have been limited by the relatively modest absolute numbers of patients affected, so that for many of these conditions evidence is insufficient to guide clinical decisions.
The aim of this research proposal is to investigate the associations between a range of chronic inflammatory conditions and different types of cardiovascular disorders, by using one of the largest longitudinal healthcare datasets available for research purposes in the world. The study design leverages the potential of ‘big data’ to explore complex disease associations through a unique combination of skills – my own knowledge of epidemiology and experience with the studied data set; my host supervisor’s expertise in statistical models best suited for the analysis of longitudinal data; and interdisciplinary clinical expertise through an international network of collaborations.
A better understanding of cardiovascular risks associated with chronic inflammatory conditions may help guidelines and clinicians to focus on patients for which screening and treatments are more likely to have an effect, and improve the prevention of cardiovascular diseases. Differences between conditions may further point towards biological functions underlying these complications and inform the design of future research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health epidemiology
- natural sciences computer and information sciences data science big data
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- natural sciences mathematics applied mathematics statistics and probability
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3000 LEUVEN
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.