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Origin: reconstructing African prehistory using ancient DNA

Project description

Latest DNA technology uncovers African prehistory

Knowledge of the human evolutionary process in Africa is instrumental for the comprehension of the origins of our species. However, as few ancient genomes from Africa are available, genetic studies look into the varieties of humans in contemporary Africa. Consequently, our knowledge of Africa’s population history is limited if compared to the scientific results concerning the movements of different humans in Europe. The EU-funded ORIGIN project aims to fill the knowledge gap, taking advantage of the recent developments in aDNA methodology. It will use genomes from ancient Africans as far back as the Later Stone Age to generate genome-wide data and compare them with the available data from present Africans.

Objective

Human history in Africa over the last tens of thousands of years is an integral part of understanding the origins of our species. The starting point for most genetic studies of human origins has been based on the depth of present-day human diversity between and within African populations. Even though aDNA studies provided additional resolution and transformed our understanding of the past demography of different human groups reaching as far as ~430ka in Europe, due to the challenging conditions for endogenous DNA preservation, relatively few ancient genomes have been recovered from Africa compared to Europe and Asia, limiting our insights into the population history of the African continent. This project aims to fill-in this gap by making use of the recent advancements in aDNA methodology and generate genome-wide data from a larger number of ancient African individuals across the continent and dating as far back as the Later Stone Age, i.e. to at least ~20ka. These ancient genomes will be analysed together with the published present-day and ancient modern human, as well as archaic datasets in order to investigate migrations, level of interactions, admixture and population structure of different human groups within Africa, as well as between Africa and other parts of the world.

Coordinator

THE FRANCIS CRICK INSTITUTE LIMITED
Net EU contribution
€ 212 933,76
Address
1 MIDLAND ROAD
NW1 1AT London
United Kingdom

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Region
London Inner London — West Camden and City of London
Activity type
Research Organisations
Links
Total cost
€ 212 933,76