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Fecal miRNAs, new mediators of host-microbiota interaction in Inflammatory Bowel Disease

Project description

Small RNA molecules in our poo may mediate changes leading to chronic bowel inflammation

Our intestine is host to millions of microorganisms that make up our intestinal microbiota and play a critical role in health and disease. Changes in microbiota composition with inflammatory bowel disease (IBD) including ulcerative colitis and Crohn's disease may be related to changes in intestinal microRNAs (miRNAs). miRNAs are a recently discovered family of small non-coding RNA molecules that modulate gene expression post-transcriptionally and are implicated in a variety of clinical diseases. miR-IBD is investigating whether changes in faecal miRNAs modulate intestinal microbiota, mediating chronic intestinal inflammation in IBD. Aside from highlighting potential diagnostic and therapeutic pathways for IBD, miRNA modulation of host-microbiota interactions could be relevant to similar processes such as parasite-host and parasite-microbiota interactions.

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution
€ 196 707,84
Address
Rue De Tolbiac 101
75654 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00