Project description DEENESFRITPL A closer look at melanin structure The colour of our hair, skin and eyes is due to melanin, which provides pigmentation for the cells. Melanin, also characterised as heterogenous, deeply coloured and insoluble, protects our skin from the sun. Its polydopamine synthetic analogue has raised great interest in the materials community. However, there is a lack of understanding of its functions due to its heterogeneous polymer structure. In this context, the EU-funded Mel.Photo.Protect project will fill the knowledge gap by explaining the melanin structure and its general photo-protecting function by utilising computational chemistry. The findings will also shed light on the possible pathogenic role of melanin chemiexcitation and provide new principles for the design of polydopamine-based functional materials. Show the project objective Hide the project objective Objective Melanin is the deeply coloured, insoluble and heterogenous biopolymer of animal skin, hair and eyes responsible for protection against harmful light action. It also has a pathogenic role as a generator of reactive oxygen species and possibly through chemiexcitation, and its polydopamine synthetic analogue has raised great interest in the materials community. In spite of these multiple points of interest, the details of melanin structure and its main photoprotecting function are still largely unknown, mostly due to the heterogeneous polymer structure. Closing this gap is an urgent challenge, and our proposal aims at doing that with the methods of computational chemistry. Based on the widely accepted hierarchical structure model for melanin, in WP1 we will generate a library of aggregates made of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oligomers with different connectivity and redox state (diol, semiquinone and quinone forms). In WP2 we will simulate the absorption spectra of the aggregates and compare them with the experimental melanin spectrum, which starts at the near IR and increases monotonically into the UV. In WP3 we will simulate the excited-state decay mechanisms for the different aggregates in order to explain melanin's lack of fluorescence, which is indicative of fast decay responsible for its photoprotecting function. The results of our project will provide a new view on the photoprotecting function of melanin based on a systematic consideration of its heterogeneous structure, and they will allow us to assess what specific aggregates are responsible for the different functional characteristics. They will help us to assess the possible pathogenic role of melanin chemiexcitation, and provide new principles for design of PDA-based functional materials. Fields of science natural sciencesbiological sciencesbiochemistry Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2018 - Individual Fellowships Call for proposal H2020-MSCA-IF-2018 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator UNIVERSITAT DE GIRONA Net EU contribution € 172 932,48 Address Placa sant domenec 3 17004 Girona Spain See on map Region Este Cataluña Girona Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
