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Prefrontal plasticity underpinning resilience against cognitive ageing.

Project description

Identification of resilience mechanisms against cognitive ageing

Cognitive ageing affects aspects such as memory, attention and decision making, and often leads to conditions like Alzheimer's disease. Undoubtedly, there is an interindividual variability in terms of neuropathology onset, and insight into the determinant factors will help design effective rehabilitation strategies. The key objective of the EU-funded AGEING PLASTICITY project is to identify neurocognitive markers of healthy ageing. For this purpose, scientists will study the right frontoparietal network in the brain and associate specific biomarkers with structural changes. Given the millions of people suffering from Alzheimer's disease worldwide, project results will assist against cognitive decline.

Objective

As global life-expectancy increases so do pathological age-related conditions impacting cognition. The worldwide prevalence of Alzheimer’s Disease is expected to rise from 46 to 131.5 million affected people in the next 30 years, which will drastically compromise quality of life for many individuals and place a considerable economic burden on society. As acknowledged by the EU Commission, there is an imperative to ‘improve our understanding of the causes and mechanisms underlying…healthy ageing and disease. Older adults differ vastly in the extent to which their cognitive functions, such as memory, attention, and decision making remain healthy. Highlighting sources of interindividual variability in this resilience to cognitive ageing, particularly in the face of neuropathology such as Alzheimer’s Disease will enhance the development of targeted neurorehabilitation interventions to prevent and redress cognitive decline. Several lines of work indirectly indicate the right fronto-parietal network (rFPN) in the brain, particularly the dorsolateral prefrontal cortex, is critical for healthy cognition in ageing. This proposal will combine advanced cognitive neuroscience techniques to directly investigate whether neurocognitive markers of healthy ageing (i) relate to interindividual differences in white-matter (WM) structural organisation within the rFPN, and (ii) can be improved by upregulating activity within this network. This fellowship will be conducted at the Oxford Department of Experimental Psychology under the supervision of Prof Kia Nobre, world expert on the cognitive neuroscience of attention, and in close collaboration with Prof Heidi Johansen-Berg, leading authority on white matter plasticity at the Wellcome Centre for Integrative Neuroimaging (WIN).

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Net EU contribution
€ 212 933,76
Address
WELLINGTON SQUARE UNIVERSITY OFFICES
OX1 2JD Oxford
United Kingdom

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Links
Total cost
€ 212 933,76