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Prefrontal plasticity underpinning resilience against cognitive ageing.

Descripción del proyecto

Identificación de los mecanismos de resiliencia contra el envejecimiento cognitivo

El envejecimiento cognitivo afecta a aspectos como la memoria, la atención y la toma de decisiones, y a menudo da lugar a afecciones como la enfermedad de Alzheimer. Sin duda, existe una variabilidad interindividual en cuanto al inicio del trastorno neurológico, y el conocimiento de los factores determinantes ayudará a formular unas estrategias de rehabilitación eficaces. El objetivo principal del proyecto financiado con fondos europeos AGEING PLASTICITY es determinar los marcadores neurocognitivos del envejecimiento saludable. Para este fin, un grupo de científicos estudiará la red frontoparietal derecha del encéfalo y asociará biomarcadores específicos con cambios estructurales. Los resultados del proyecto ayudarán a luchar contra el deterioro cognitivo, algo fundamental teniendo en cuenta que millones de personas en todo el mundo sufren la enfermedad de Alzheimer.

Objetivo

As global life-expectancy increases so do pathological age-related conditions impacting cognition. The worldwide prevalence of Alzheimer’s Disease is expected to rise from 46 to 131.5 million affected people in the next 30 years, which will drastically compromise quality of life for many individuals and place a considerable economic burden on society. As acknowledged by the EU Commission, there is an imperative to ‘improve our understanding of the causes and mechanisms underlying…healthy ageing and disease. Older adults differ vastly in the extent to which their cognitive functions, such as memory, attention, and decision making remain healthy. Highlighting sources of interindividual variability in this resilience to cognitive ageing, particularly in the face of neuropathology such as Alzheimer’s Disease will enhance the development of targeted neurorehabilitation interventions to prevent and redress cognitive decline. Several lines of work indirectly indicate the right fronto-parietal network (rFPN) in the brain, particularly the dorsolateral prefrontal cortex, is critical for healthy cognition in ageing. This proposal will combine advanced cognitive neuroscience techniques to directly investigate whether neurocognitive markers of healthy ageing (i) relate to interindividual differences in white-matter (WM) structural organisation within the rFPN, and (ii) can be improved by upregulating activity within this network. This fellowship will be conducted at the Oxford Department of Experimental Psychology under the supervision of Prof Kia Nobre, world expert on the cognitive neuroscience of attention, and in close collaboration with Prof Heidi Johansen-Berg, leading authority on white matter plasticity at the Wellcome Centre for Integrative Neuroimaging (WIN).

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Coordinador

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Aportación neta de la UEn
€ 212 933,76
Dirección
Wellington square university offices
OX1 2JD Oxford
Reino Unido

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Región
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Otras fuentes de financiación
€ 0,00