Project description DEENESFRITPL The first basic and applied study of autophagy in strawberry Autophagy is the main resistance mechanism against biotic and abiotic stresses in different plant species. However, little is known about the effect of autophagy induction on the response of plants to stresses. This issue assumes greater importance within the context of global warming, given that the production of crops with higher resistance to heat and drought becomes essential. The EU-funded FrATGaria project will study the role of autophagy in the maturation of one of the most important berry fruits in the EU, strawberry (Fragaria x ananassa). The project will generate transgenic plants with increased autophagy and focus on analysing the potential benefits regarding general development, fruit quality and stress resistance that these plants can have compared to wild type. Show the project objective Hide the project objective Objective "Autophagy, the major catabolic pathway in eukaryotic cells, has a role in the resistance to biotic and abiotic stresses in different plant species. Plenty of studies show that blocking autophagy by knocking out some of its essential genes leads to plants highly susceptible to this stresses (including heat and drought). However, there are much less studies about the effect of autophagy induction on the response of plants to stresses. Present situation of global warming is already having an effect in agriculture due to a rise in temperature and to water shortages. Therefore, generation of crops with higher resistance to heat and drought should be a priority nowadays. In this proposal I will study the role of autophagy in the maturation of one of the most important berry fruit in EU, Strawberry (Fragaria x ananassa). I will determine the importance of this catabolic process in the response to heat/drought stress in this crop. Furthermore, I will use the diploid strawberry model specie Fragaria vesca to generate transgenic plants with increased autophagy by CRISPR/Cas9 and CRISPR/dCas9 genome editing and analyze the potential benefits regarding general development, fruit quality and stress resistance (this previously shown for Arabidopsis, tomato and apple) that this plants can have compare to wild type. This will be the first basic and applied study of autophagy in strawberry. ""FrATGaria"" will combine my experience in the autophagy field with the expertise of the host group in strawberry development and fruit ripening and will benefit from active collaboration with strawberry breeding groups. The development of this project will allow me to broaden my knowledge about plant development in response to stress strengthening not only my scientific skills but also my leadership, project managment and mentoring capabilities." Fields of science medical and health sciencesmedical biotechnologygenetic engineeringgene therapyagricultural sciencesagriculture, forestry, and fisheriesagriculturehorticulturefruit growingnatural sciencesbiological sciencesgeneticsgenomes Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2018 - Individual Fellowships Call for proposal H2020-MSCA-IF-2018 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator UNIVERSIDAD DE MALAGA Net EU contribution € 172 932,48 Address Avda cervantes, num. 2 29016 Malaga Spain See on map Region Sur Andalucía Málaga Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
