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Insights from within-host dynamics on the coexistence of antibiotic resistant and sensitive pathogens

Project description

Modelling of the evolution of bacterial antibiotic resistance

Bacterial antibiotic resistance is an enormous public health challenge. The coexistence of antibiotic-resistant and sensitive genotypes within the same population is still an unresolved problem. Current epidemiological models predict the dominance of either of the two strains or suffer from generality. The EU-funded PolyPath project aims to resolve this by coupling within-host pathogen dynamics and between-host transmission of bacteria. Modelling the within-host system will enable the prediction of the rate of resistance emergence and abundance of sensitive and resistant bacteria with or without antibiotic treatment. The resistant bacteria thrive under antibiotic treatment, while the sensitive strain has an advantage in invading and colonising untreated hosts. The project will help to identify the optimal treatment strategies to solve the antibiotic resistance.

Coordinator

SORBONNE UNIVERSITE
Net EU contribution
€ 184 707,84
Address
21 Rue De L'ecole De Medecine
75006 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00