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Monitoring cancer heterogeneity based on the dynamic assessment of the Warburg effect under metabolic perturbation

Project description

Metabolic imaging in cancer diagnostics

Cancer diagnosis and treatment monitoring rely on molecular imaging methods which, however, cannot fully portray disease heterogeneity. To address this problem, the EU-funded CHyMERA project proposes to develop a novel technology that can image cancer phenotypes. The approach measures the kinetics of glucose flux through different metabolic pathways under different tumour microenvironment conditions and their association with cell proliferation. The CHyMERA methodology has a strong potential for clinical translation and is expected to improve specificity to cancer diagnosis and monitoring of treatment response.

Coordinator

FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
Net EU contribution
€ 159 815,04
Address
Avenida Brasilia, Centro De Investigacao Da Fundacao Champalimaud
1400-038 Lisboa
Portugal

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Research Organisations
Non-EU contribution
€ 0,00