The hormone connection between obesity and breast cancer
Breast cancer risk increases after menopause, when oestradiol drops markedly and oestrone serves as the main oestrogen. Obesity and high oestrone levels are considered risk factors for the development of oestrogen receptor-positive breast cancer in postmenopausal women. Scientists of the EU-funded EOBRECA project are investigating the role of adipose tissue chronic inflammation and the NF-kB pathway in breast cancer onset. They aim to delineate the regulatory role of oestrone in the NF-kB pathway and determine the oncogenic role of enzymes implicated in the oestradiol to oestrone conversion. The project has the potential to identify novel therapeutic targets against oestrogen receptor-positive breast cancers, paving the way for new preventative and treatment strategies.