Project description
Organ-on-a-chip technology for studying metabolic diseases
Non-alcoholic fatty liver disease (NAFLD) is associated with the deregulation of adipose tissue lipolysis. Although hepatic cell insulin resistance may be the underlying culprit, there is a need to understand how hepatic and adipocyte insulin resistance develop and influence each other. To address this limitation and study liver–adipose tissue crosstalk, the EU-funded LIV-AD-ON-CHIP project will develop a two-organ-on-a-chip model. Researchers will culture hepatocytes and adipocytes in connected systems and undertake transcriptomic and metabolomic analyses after inducing insulin resistance. This in vitro model can be used with patient-specific cells to identify potential biomarkers and new biomarkers of NAFLD or other metabolic diseases.
Fields of science
Programme(s)
Funding Scheme
MSCA-IF-EF-ST - Standard EFCoordinator
72074 Tuebingen
Germany
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Participants (1)
Participation ended
80686 Munchen
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