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Unmasking insulin resistance triggering mechanisms using microphysiological two-organ systems as in vitro disease models of metabolic syndrome and non-alcoholic fatty liver disease

Project description

Organ-on-a-chip technology for studying metabolic diseases

Non-alcoholic fatty liver disease (NAFLD) is associated with the deregulation of adipose tissue lipolysis. Although hepatic cell insulin resistance may be the underlying culprit, there is a need to understand how hepatic and adipocyte insulin resistance develop and influence each other. To address this limitation and study liver–adipose tissue crosstalk, the EU-funded LIV-AD-ON-CHIP project will develop a two-organ-on-a-chip model. Researchers will culture hepatocytes and adipocytes in connected systems and undertake transcriptomic and metabolomic analyses after inducing insulin resistance. This in vitro model can be used with patient-specific cells to identify potential biomarkers and new biomarkers of NAFLD or other metabolic diseases.

Coordinator

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Net EU contribution
€ 145 621,50
Address
Geschwister-scholl-platz
72074 Tuebingen
Germany

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Region
Baden-Württemberg Tübingen Tübingen, Landkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,01

Participants (1)

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV

Participation ended

Germany
Net EU contribution
€ 17 184,90
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00