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Dissecting GLP-1 receptor internalization pathways using genetic and pharmacological tools

Project description

Following the passing of the baton in the race to stimulate insulin secretion

G-protein-coupled receptors (GPCRs) are a large and ubiquitous family of transmembrane proteins that mediate the majority of cellular responses to external stimuli. The glucagon-like peptide-1 receptor (GLP-1R) is one of these, an important target in the treatment of type 2 diabetes mellitus, whose prevalence has risen dramatically irrespective of income levels. Binding to its agonist causes GLP-1R to be internalised in the cell, leading to stimulation of insulin secretion. However, the mechanisms remain largely unknown. INTERGLP1 is developing cell lines to study GPCR signalling and GLP-1R internalisation. Making the 'tools' available to the scientific community should significantly speed the development of treatments for diabetes and a host of other GPCR-related conditions.


Net EU contribution
€ 207 312,00
Norregade 10
1165 Kobenhavn

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Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00