Descripción del proyecto
Enfoque dirigido al huésped para curar las infecciones fúngicas invasivas
Las infecciones fúngicas invasivas (IFI) representan una importante amenaza en el caso de los pacientes inmunocomprometidos y gravemente enfermos, ya sean adultos o pediátricos. Los expertos creen que un enfoque dirigido al huésped podría ayudar a mejorar la situación actual. El proyecto financiado con fondos europeos HDM-FUN propone un enfoque transdisciplinario para identificar factores de riesgo de intervenciones médicas dirigidas al huésped en casos de IFI. El objetivo global es identificar los factores huésped-patógeno esenciales para la inmunoterapia y la profilaxis, para permitir así diseñar nuevos enfoques terapéuticos y de medicina preventiva dirigidos al huésped para pacientes con infecciones fúngicas invasivas letales en cuidados intensivos. HDM-FUN reúne a importantes científicos e investigadores clínicos para estudiar la genética y los factores de transcripción del huésped, los moduladores inmunitarios del microbioma y el metaboloma, y las interacciones huésped-patógeno a nivel molecular y celular que determinan la susceptibilidad y el resultado del tratamiento en los pacientes con infecciones fúngicas.
Objetivo
Despite novel treatment options and development of diagnostic tools invasive fungal infections (IFI) are still associated with an unacceptably high mortality and morbidity. Experts believe that a host directed approach is needed to overcome this problem. HDM-FUN proposes a transdisciplinary approach to identify host-pathogen factors (HPFs) needed for host directed medical interventions in IFI and will be the first of its kind.
The overall concept is to identify host-pathogen factors in the setting of immunotherapy and prophylaxis that will allow the design for tailored novel therapeutic and preventive host-directed medicine approaches for patients with lethal invasive fungal infection in the intensive care.
Specific objectives:
1. To identify host-pathogen factors that correlate with disease, and correlate them with preventive or immunotherapy- based strategies to stratify patients for personalized host-directed treatment options.
2. Two clinical trials of host-directed medicine approaches; an immunotherapy trial in patients with candidemia and a prospective observational trial for prophylaxis in patients with influenza at risk for aspergillosis.
3. To set-up a centrally managed biobank with samples of the patients enrolled in both clinical trials, and to standardize experimental procedures, protocols and centralize analysis.
4. To establish a unique infrastructure aimed to: explore host-directed medicine approaches in IFI, evaluate their impact on patients and health care, translate research efforts to clinical practice by designing point of care tests and teaching medical professionals.
HDM-FUN brings together top scientists and clinical researchers to unravel host factors (genetics and transcription), immune modulators (metabolome, microbiome), and host pathogen interactions (genetics, metabolomics, immunology, signalling pathways, phagosome biogenesis, and inflammasome regulation) that determine the susceptibility and outcome of patients with fungal infection.
Ámbito científico
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-SC1-2019-Two-Stage-RTD
Régimen de financiación
RIA - Research and Innovation actionCoordinador
6525 GA Nijmegen
Países Bajos