Host directed medicine in invasive fungal infection

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Report on journalistic and scientific immunotherapy narratives

An analysis will be performed of the Englishlanguage journalistic and scientific discourse surrounding immunotherapy for infections

Development of project website and project visual identity

Development of a project website and of a logo that visually identifies the project and allow people to recognise the HDMFUN message at the first glance

Publicaciones

Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study

Autores: Simon Feys, MD Samuel M Gonçalves, MSc * Mona Khan, PhD * Sumin Choi, MSc * Bram Boeckx, PhD Denis Chatelain, MD Cristina Cunha, PhD Yves Debaveye, MD Prof Greet Hermans, MD Marjan Hertoghs, MD Steph
Publicado en: The Lancet Respiratory Medicine, Edición monthly, 2022, Página(s) P1147-1159
Editor: Elsevier
DOI: 10.1016/s2213-2600(22)00259-4

Enteric delivery of indole-3-carboxylic acid unlocks therapeutic potential of postbiotic metabolite cascade

Autores: Matteo Puccetti, Marilena Pariano, Claudia Stincardini, Consuelo Fabi, Roberta Galarini, Carolina Barola, Husam Br. Alabed, Dorotea Frongia Mancini, Roberto Maria Pellegrino, Enrico Garaci, Maurizio Ricci, Luigina Romani, Stefano Giovagnoli
Publicado en: International Journal of Pharmaceutics, Edición 684, 2025, Página(s) 126158, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.126158

Rapidly expanded partially HLA DRB1–matched fungus-specific T cells mediate in vitro and in vivo antifungal activity

Autores: Gloria Castellano-González, Helen M. McGuire, Fabio Luciani, Leighton E. Clancy, Ziduo Li, Selmir Avdic, Brendan Hughes, Mandeep Singh, Barbara Fazekas de St Groth, Giorgia Renga, Marilena Pariano, Marina M. Bellet, Luigina Romani, David J. Gottlieb
Publicado en: Blood Advances, Edición 4/14, 2020, Página(s) 3443-3456, ISSN 2473-9529
Editor: Europe PMC
DOI: 10.1182/bloodadvances.2020001565

Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway

Autores: Jia, Lei-Jie; Rafiq, Muhammad; Radosa, Lukáš; Hortschansky, Peter; Cunha, Cristina; Cseresnyés, Zoltán; Krüger, Thomas; Schmidt, Franziska; Heinekamp, Thorsten; Straßburger, Maria; Löffler, Bettina; Doenst, Torsten; Lacerda, João; Campos, António; Figge, Marc Thilo; Carvalho, Agostinho; Kniemeyer, Olaf; Brakhage, Axel A.
Publicado en: Cell Host Microb, Edición 31 (3), 2023, Página(s) 16, ISSN 1934-6069
Editor: Cell Press
DOI: 10.1016/j.chom.2023.02.002

Hypoxia inducible-factor 1 alpha regulates neutrophil recruitment during fungal-elicited granulomatous inflammation

Autores: da Silva-Ferreira S, Duarte-Oliveira C, Antunes D, Barbosa-Matos C, Mendes-Frias A, Torrado E, Costa S, Silvestre R, Cunha C, Carvalho A
Publicado en: Frontiers in Cellular and Infection Microbiology, Edición 12, 2022, Página(s) 1005839, ISSN 2235-2988
Editor: Frontiers Media S. A.
DOI: 10.3389/fcimb.2022.1005839

Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium

Autores: Jose Manuel Sánchez-Maldonado, Ana Moñiz-Díez, Rob ter Horst, Daniele Campa, Antonio José Cabrera-Serrano, Manuel Martínez-Bueno, María del Pilar Garrido-Collado, Francisca Hernández-Mohedo, Laura Fernández-Puerta, Miguel Ángel López-Nevot, Cristina Cunha, Pedro Antonio González-Sierra, Jan Springer, Michaela Lackner, Laura Alcazar-Fuoli, Luana Fianchi, José María Aguado, Livio Pagano
Publicado en: Journal of Fungi, Edición 7/1, 2021, Página(s) 4, ISSN 2309-608X
Editor: -
DOI: 10.3390/jof7010004

Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study.

Autores: Feys S, Vanmassenhove S, Kraisin S, Yu K, Jacobs C, Boeckx B, Cambier S, Cunha C, Debaveye Y, Gonçalves SM, Hermans G, Humblet-Baron S, Jansen S, Lagrou K, Meersseman P, Neyts J, Peetermans M, Rocha-
Publicado en: The Lancet Microbe., Edición 5(3), 2024, Página(s) e247-e260.
Editor: Elsevier Ltd.
DOI: 10.1016/s2666-5247(23)00368-3

Harnessing inter-kingdom metabolic disparities at the human-fungal interface for novel therapeutic approaches.

Autores: Claudio Costantini, Marilena Pariano, Matteo Puccetti, Stefano Giovagnoli , Gioena Pampalone , Mirco Dindo , Barbara Cellini , Luigina Romani.
Publicado en: Front Mol Biosci, Edición 11, 2024, Página(s) 1386598, ISSN 1746-2665
Editor: Frontiers
DOI: 10.3389/fmolb.2024.1386598

The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19

Autores: Arianna Di Stadio, Claudio Costantini, Giorgia Renga, Marilena Pariano, Giampietro Ricci, Luigina Romani
Publicado en: Life, Edición 10/12, 2020, Página(s) 345, ISSN 2075-1729
Editor: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/life10120345

Glutamine Metabolism Supports the Functional Activity of Immune Cells against Aspergillus fumigatus

Autores: Daniela Antunes; Samuel M. Gonçalves; Vasiliki Matzaraki; Cláudia S. Rodrigues; Relber A. Gonçales; Joana Rocha; Jorge Sáiz; António Marques; Egídio Torrado; Ricardo Silvestre; Fernando Rodrigue
Publicado en: Microbiol Spectr, Edición 11(1), 2023, Página(s) e0225622
Editor: American Society for Microbiology,
DOI: 10.1128/spectrum.02256-22

Aspergillus fumigatus and aspergillosis: From basics to clinics

Autores: Arastehfar A, Carvalho A, Houbraken J, Lombardi L, Garcia-Rubio R, Jenks JD, Rivero-Menendez O, Aljohani R, Jacobsen ID, Berman J, Osherov N, Hedayati MT, Ilkit M, Armstrong-James D, Gabaldón T, Mele
Publicado en: Studies in Mycology, Edición May 10;100, 2021, Página(s) 100115
Editor: Westerdijk Fungal Biodiversity Institute
DOI: 10.1016/j.simyco.2021.100115

The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries

Autores: Hoenigl M, Seidel D, Carvalho A, Rudramurthy SM, Arastehfar A, Gangneux JP, Nasir N, Bonifaz A, Araiza J, Klimko N, Serris A, Lagrou K, Meis JF, Cornely OA, Perfect JR, White PL, Chakrabarti A
Publicado en: Lancet Microbe, Edición Jul;3(7), 2022, Página(s) e543-e552, ISSN 2666-5247
Editor: Elsevier
DOI: 10.1016/s2666-5247(21)00237-8

Transient anti-cytokine autoantibodies superimpose the hyperinflammatory response in Kawasaki disease and multisystem inflammatory syndrome in children: a comparative cohort study on correlates of disease

Autores: Stejara A. Netea, Giske Biesbroek, Diana van Stijn, Hanna Ijspeert, Caspar I. van der Made, Machiel H. Jansen, Judy Geissler, J.M. (Merlijn) van den Berg, Martijn van der Kuip, Mariken P. Gruppen, Dieneke Schonenberg-Meinema, Berber Kapitein, A.M. (Marceline) Tutu van Furth, Sietse Q. Nagelkerke, Dasja Pajkrt, Frans B. Plötz, M.E.J. (Lisette) den Boer, Gijs W. Landman, Marlies A. van Houten, Ines
Publicado en: eBioMedicine, Edición 95, 2023, Página(s) 104736, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104736

Mucoricin binding to β-glucan sites on germinating Mucorales spores disrupts neutrophil swarming to promote pathogenicity

Autores: Stavroula Baimpa, Matthaios Sertedakis, Elias Drakos, Tonia Akoumianaki, Alexandra Vatikioti, Yiyou Gu, Sanam Dolati, Anastasios Koutsopoulos, Ashraf S. Ibrahim, Georgios Chamilos
Publicado en: bioRxiv, Edición October 29, 2026, ISSN 2692-8205
Editor: openRxiv
DOI: 10.1101/2025.10.28.685056

Alpha1-antitrypsin impacts innate host–pathogen interactions with Candida albicans by stimulating fungal filamentation

Autores: Martin Jaeger; Axel Dietschmann; Sophie Austermeier; Sude Dinçer; Pauline Porschitz; Larsen Vornholz; Ralph J.A. Maas; Evelien G.G. Sprenkeler; Jürgen Ruland; Stefan Wirtz; Tania Azam; Leo A.B. Joosten; Bernhard Hube; Mihai G. Netea; Charles A. Dinarello; Mark S. Gresnigt
Publicado en: Virulence, 15, 1, pp. 2333367, Edición 9, 2024, ISSN 2150-5594
Editor: Landes Bioscience
DOI: 10.1080/21505594.2024.2333367

Bacteria and fungi of the lung: allies or enemies?

Autores: Enrico Garaci, Marilena Pariano, Emilia Nunzi, Claudio Costantini, Marina Maria Bellet, Cinzia Antognelli, Matteo Antonio Russo, Luigina Romani
Publicado en: Frontiers in Pharmacology, Edición 15, 2024, Página(s) 1497173, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1497173

Targeting immunometabolism in host-directed therapies to fungal disease

Autores: Gonçalves SM, Ferreira AV, Cunha C, Carvalho A
Publicado en: Clinical Experimental Immunology, Edición Jun 11;208(2), 2022, Página(s) 158-166., ISSN 1365-2249
Editor: Oxford Academic
DOI: 10.1093/cei/uxab014

Profound cell wall remodeling in Candida parapsilosis during systemic infection confers simultaneous tolerance to echinocandins and host immunity

Autores: 53. Farnaz Daneshnia, Liuyang Cai, Deepika Gunasekaran, Isha Gautam, Austin Perry, Pegah Mosharaf Ghahfarokhy, Arefeh Ebadati, Julieta Munoz, Dorian Padilla, Süleyha Hilmioglu-Polat, Shenglin Mei, Daniel J. Floyd, Miquel Àngel Schikora-Tamarit, Diego Funtes, Maria Artigués-Lleixà, Louise Walker, Samuel M. Gonçalves, Mostafa Salehi, Agostinho Carvalho, Jigar V. DesaiDavid S. Perlin, Carol Munr
Publicado en: Microbiology spectrum, Edición in press, 2025, ISSN 2165-0497
Editor: the American Society for Microbiology

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

Autores: Christophe d'Enfert, Ann-Kristin Kaune, Leovigildo-Rey Alaban, Sayoni Chakraborty, Nathaniel Cole, Margot Delavy, Daria Kosmala, Benoît Marsaux, Ricardo Fróis-Martins, Moran Morelli, Diletta Rosati, Marisa Valentine, Zixuan Xie, Yoan Emritloll, Peter A Warn, Frédéric Bequet, Marie-Elisabeth Bougnoux, Stephanie Bornes, Mark S Gresnigt, Bernhard Hube, Ilse D Jacobsen, Mélanie Legrand, Salomé L
Publicado en: FEMS Microbiology Reviews, Edición 45/3, 2020, Página(s) fuaa060, ISSN 1574-6976
Editor: -
DOI: 10.1093/femsre/fuaa060

Microbiota-derived metabolites as diagnostic markers for respiratory fungal infections

Autores: Anaїs Hérivaux, Samuel M. Gonçalves, Agostinho Carvalho, Cristina Cunha
Publicado en: Journal of Pharmaceutical and Biomedical Analysis, Edición 189, 2020, Página(s) 113473, ISSN 0731-7085
Editor: Elsevier BV
DOI: 10.1016/j.jpba.2020.113473

The development of single-domain VHH nanobodies that target the Candida albicans cell surface

Autores: Giuseppe Buda De Cesare, Frank M. Sauer, Anna Kolecka, Aimilia A. Stavrou, Theo C. Verrips, Teun Boekhout, Edward Dolk, Carol A. Munro
Publicado en: Microbiology Spectrum, Edición 12, 2024, Página(s) e0426923, ISSN 2165-0497
Editor: American Society for Microbiology
DOI: 10.1128/spectrum.04269-23

Functional Lipid Analysis via Index-Based Lipidomics Profile: A New Computational Module in LipidOne

Autores: H. B. R. Alabed, D. F. Mancini, M. Pergola, L. Romani, S. Martino, A. Koulman, R. M. Pellegrino
Publicado en: bioRxiv, Edición in press, 2026, ISSN 2692-8205
Editor: openRxiv
DOI: 10.1101/2025.11.04.686489

Lung microbiota predict invasive pulmonary aspergillosis and its outcome in immunocompromised patients

Autores: Anaïs Hérivaux, Jesse R Willis, Toine Mercier, Katrien Lagrou, Samuel M Gonçalves, Relber A Gonçales, Johan Maertens, Agostinho Carvalho, Toni Gabaldón, Cristina Cunha
Publicado en: Thorax, 2021, Página(s) thoraxjnl-2020-216179, ISSN 0040-6376
Editor: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2020-216179

Pyridoxal 5′-Phosphate-Dependent Enzymes at the Crossroads of Host–Microbe Tryptophan Metabolism

Autores: Barbara Cellini, Teresa Zelante, Mirco Dindo, Marina M. Bellet, Giorgia Renga, Luigina Romani, Claudio Costantini
Publicado en: International Journal of Molecular Sciences, Edición 21/16, 2020, Página(s) 5823, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165823

Genetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis

Autores: Matzaraki V, Beno A, Jaeger M, Gresnigt MS, Keur N, Boahen C, Cunha C, Gonçalves SM, Leite L, Lacerda JF, Campos A Jr, van de Veerdonk FL, Joosten L, Netea MG, Carvalho A, Kumar V
Publicado en: Redox Biology, Edición Jul 4;55:, 2022, Página(s) 102391
Editor: Elsevier
DOI: 10.1016/j.redox.2022.102391

COVID-19-associated fungal infections

Autores: Hoenigl M, Seidel D, Sprute R, Cunha C, Oliverio M, Goldman GH, Ibrahim AS, Carvalho A
Publicado en: Nature Microbiology, Edición Aug;7(8), 2022, Página(s) 1127-1140, ISSN 2058-5276
Editor: Nature Springer
DOI: 10.1038/s41564-022-01172-2

Future Prospects and Challenges in Mucormycosis Research

Autores: Georgios Chamilos, Ulrike Binder, Victoriano Garre
Publicado en: Journal of Fungi, Edición 11, 2025, Página(s) 545, ISSN 2309-608X
Editor: MDPI AG
DOI: 10.3390/jof11080545

A Functional Polymorphism in IL-36β Modulates Macrophage Antifungal Effector Functions and Increases Susceptibility to Invasive Pulmonary Aspergillosis

Autores: Samuel M Gonçalves, Luis Leite, Pedro de Vasconcelos, Inês Pereira, Intan M W Dewi, Toine Mercier, Robina Aerts, Dário Ligeiro, Filomena Mendes, Fátima Freitas, Jorge Condeço, Joana Vieira, Eduardo Espada, Katrien Lagrou, Johan A Maertens, Mark S Gresnigt, Charles A Dinarello, João F Lacerda, Carlos Pinho Vaz, Cristina Cunha, Agostinho Carvalho, Frank L van de Veerdonk
Publicado en: The Journal of Infectious Diseases, Edición 232, 2025, Página(s) 1208-1219, ISSN 0022-1899
Editor: University of Chicago Press
DOI: 10.1093/infdis/jiaf301

Regulation of gliotoxin biosynthesis and protection in Aspergillus species

Autores: de Castro PA, Colabardini AC, Moraes M, Horta MAC, Knowles SL, Raja HA, Oberlies NH, Koyama Y, Ogawa M, Gomi K, Steenwyk JL, Rokas A, Gonçales RA, Duarte-Oliveira C, Carvalho A, Ries LNA, Goldman GH
Publicado en: PLoS Genetics, Edición Jan;18(1), 2022, Página(s) e1009965, ISSN 1553-7390
Editor: Public Library of Science
DOI: 10.1371/journal.pgen.1009965

Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity

Autores: Ries LNA, Alves de Castro P, Pereira Silva L, Valero C, Dos Reis TF, Saborano R, Duarte IF, Persinoti GF, Steenwyk JL, Rokas A, Almeida F, Costa JH, Fill T, Sze Wah Wong S, Aimanianda V, Rodrigues FJS
Publicado en: mBio, Edición Aug 31;12(4), 2021, Página(s) e0168221
Editor: American Society of Microbiology
DOI: 10.1128/mbio.01682-21

The immune and microbial homeostasis determines the Candida-mast cells cross-talk in celiac disease

Autores: Giorgia Renga, Marilena Pariano, Fiorella D'Onofrio, Giuseppe Pieraccini, Claudia Di Serio, Valeria Rachela Villella, Carlo Abbate, Matteo Puccetti , Stefano Giovagnoli, Claudia Stincardini, Marina Maria Bellet, Maurizio Ricci, Claudio Costantini, Vasileios Oikonomou, Luigina Romani.
Publicado en: Life Sci Alliance, Edición 7, 2024, Página(s) e202302441, ISSN 2575-1077
Editor: -
DOI: 10.26508/lsa.202302441

A shifted composition of the lung microbiota conditions the antifungal response of immunodeficient mice

Autores: Emilia Nunzi, Giorgia Renga, Melissa Palmieri, Giuseppe Pieraccini, Marilena Pariano, Claudia Stincardini, Fiorella D’Onofrio, Ilaria Santarelli, Marina Maria Bellet, Andrea Bartoli, Claudio Costantini, Luigina Romani
Publicado en: International Journal of Molecular Sciences, Edición Aug 6;22(16), 2021, Página(s) 8474, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22168474

sMR and PTX3 levels associate with COVID-19 outcome and survival but not with Long COVID

Autores: Lisa Hurler, Federica Mescia, Laura Bergamaschi, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Erika Kajdácsi, György Sinkovits, László Cervenak, Zoltán Prohászka, Paul A. Lyons, and Erik J.M. Toonen.
Publicado en: iScience., Edición VOLUME 27, ISSUE 7, 2024, Página(s) 110162, ISSN 2589-0042
Editor: Cell Press
DOI: 10.1016/j.isci.2024.110162

Paracoccin Overexpression in Paracoccidioides brasiliensis Enhances Fungal Virulence by Remodeling Chitin Properties of the Cell Wall

Autores: Gonçales RA, Ricci-Azevedo R, Vieira VCS, Fernandes FF, Thomaz SMO, Carvalho A, Vendruscolo PE, Cunha C, Roque-Barreira MC, Rodrigues F
Publicado en: Journal of Infectious Diseases, Edición Jul 2;224(1), 2021, Página(s) 164-174, ISSN 1537-6613
Editor: Oxford Academic
DOI: 10.1093/infdis/jiaa707

Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis

Autores: Gonçales RA, Bastos HN, Duarte-Oliveira C, Antunes D, Sokhatska O, Jacob M, Rolo R, Campos CF, Sasaki SD, Donato A, Mapelli SN, Costa S, Moura CS, Delgado L, Morais A, Torrado E, van de Veerdonk FL, Weichhart T, Lambris JD, Silvestre R, Garlanda C, Mantovani A, Cunha C, Carvalho A
Publicado en: American Journal of Respiratory and Critical Care Medicine, Edición Nov 1;206(9):, 2022, Página(s) 1140-1152, ISSN 1073-449X
Editor: American Thoracic Society
DOI: 10.1164/rccm.202112-2771oc

Humoral pathways of innate immune regulation in granuloma formation

Autores: Santos-Ribeiro D, Cunha C, Carvalho A
Publicado en: Trends Immunol, Edición 45(6), 2024, Página(s) 419-427
Editor: Cell Press
DOI: 10.1016/j.it.2024.04.008

From the nose to the lungs: the intricate journey of airborne pathogens amid commensal bacteria

Autores: Claudio Costantini, Emilia Nuinzi, Luigina Romani
Publicado en: American Physiological Society, Edición Epub 2022 Aug 29, 2022, ISSN 1522-1563
Editor: American Physiological Society
DOI: 10.1152/ajpcell.00287.2022

'Mapping' Knowledge Dissemination

Autores: Nynke Bos, Lisa Vandeberg, Anke Oerlemans, Marlies Hulscher, W. Gudrun Reijnierse
Publicado en: European Journal of Health Communication, Edición 6, 2025, Página(s) 60-82, ISSN 2673-5903
Editor: University of Zurich, IKMZ – Department of Communication and Media Research
DOI: 10.47368/ejhc.2025.103

Innovative Approaches to Medical Rehabilitation: Regeneration, Immune Training, Homeostasis, and Microbiome Synergy

Autores: Enrico Garaci, Matteo Antonio Russo, Marilena Pariano, Matteo Puccetti, Consuelo Fabi, Sarah Balucchi, Marina Maria Bellet, Maurizio Ricci, Massimo Fini, Luigina Romani
Publicado en: International Journal of Molecular Sciences, Edición 26, 2025, Página(s) 8687, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26178687

Damping excessive viral-induced IFN-γ rescues the impaired anti-Aspergillus host immune response in influenza-associated pulmonary aspergillosis

Autores: Laura Seldeslachts, Frederik Staels, Marina Gkountzinopoulou, Cato Jacobs, Birger Tielemans, Eliane Vanhoffelen, Agustin Reséndiz-Sharpe, Lander De Herdt, Jeason Haughton, Teresa Prezzemolo, Oliver Burton, Simon Feys, Frank L. van de Veerdonk, Agostinho Carvalho, Lieve Naesens, Patrick Matthys, Katrien Lagrou, Erik Verbeken, Georgios Chamilos, Joost Wauters, Stephanie Humblet-Baron, Greetje Vande
Publicado en: eBioMedicine, Edición 108, 2024, Página(s) 105347, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2024.105347

Albumin Neutralizes Hydrophobic Toxins and Modulates Candida albicans Pathogenicity

Autores: Sophie Austermeier, Marina Pekmezović, Pauline Porschitz, Sejeong Lee, Nessim Kichik, David L. Moyes, Jemima Ho, Natalia K. Kotowicz, Julian R. Naglik, Bernhard Hube, Mark S. Gresnigt
Publicado en: mBio, Edición -, 2021, Página(s) e0053121, ISSN 2150-7511
Editor: -
DOI: 10.1128/mbio.00531-21

Can metaphors in patient information materials improve comprehension and attitudes regarding innovative treatment? The case of personalized immunotherapy for sepsis

Autores: Nynke Bos, W. Gudrun Reijnierse, Anke J.M. Oerlemans, Frank L. van de Veerdonk, Mihai G. Netea, Marlies E.J.L. Hulscher, Lisa Vandeberg
Publicado en: Patient Education and Counseling, Edición 141, 2026, Página(s) 109314, ISSN 0738-3991
Editor: Elsevier BV
DOI: 10.1016/j.pec.2025.109314

A signature of differential gene expression in bronchoalveolar lavage fluid predicts mortality in influenza-associated pulmonary aspergillosis

Autores: Simon Feys; Jannes Heylen; Agostinho Carvalho; Johan Van Weyenbergh; Joost Wauters; Samuel M. Gonçalves; Cristina Cunha; Yves Debaveye; Greet Hermans; Stephanie Humblet-Baron; Cato Jacobs; Diether La
Publicado en: Intensive Care Medicine, Edición 49, 2023, Página(s) 2454-257
Editor: SPRINGER LINK
DOI: 10.1007/s00134-022-06958-w

Aspergillus fumigatus biology, immunopathogenicity and drug resistance

Autores: Frank L. van de Veerdonk, Agostinho Carvalho, Joost Wauters, George Chamilos, Paul E. Verweij
Publicado en: Nature Reviews Microbiology, Edición 23, 2025, Página(s) 652-666, ISSN 1740-1526
Editor: Nature Publishing Group
DOI: 10.1038/s41579-025-01180-z

Editorial: Lung microbiome in health and disease

Autores: Kurtis Francis Budden, Luigina Romani
Publicado en: Frontiers in Pharmacology, Edición 16, 2025, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2025.1565849

Unveiling Candida albicans intestinal carriage in healthy volunteers: the role of micro- and mycobiota, diet, host genetics and immune response

Autores: Delavy, Margot; Sertour, Natacha; Patin, Etienne; Le Chatelier, Emmanuelle; Cole, Nathaniel; Dubois, Florian; Xie, Zixuan; Saint-André, Violaine; Manichanh, Chaysavanh; Walker, Alan; Quintana-Murci, Lluis; Duffy, Darragh; d'Enfert, Christophe; Bougnoux, Marie-Elisabeth; Consortium, Milieu Intérieur
Publicado en: Gut Microbes, Edición 13, 2023, Página(s) 15(2): 22876, ISSN 1949-0984
Editor: -
DOI: 10.1080/19490976.2023.2287618

Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis

Autores: Samuel M. Gonçalves, Daniela Antunes, Luis Leite, Toine Mercier, Rob ter Horst, Joana Vieira, Eduardo Espada, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, Antón
Publicado en: mBio, Edición -, 2021, Página(s) Online ahead of print, ISSN 2150-7511
Editor: -
DOI: 10.1128/mbio.00369-21

Anakinra restores immunological misfiring that drives influenza-associated pulmonary aspergillosis

Autores: Laura Seldeslachts, Sirima Kraisin, Intan M. W. Dewi, Simon Feys, Frederik Staels, Marina Gkountzinopoulou, Cato Jacobs, Birger Tielemans, Eliane Vanhoffelen, Agustin Reséndiz-Sharpe, Lander De Herdt, Oswin Kwan, Niels Vandamme, Jana Roels, Julika Neumann, Teresa Prezzemolo, Bert Malengier-Devlies, Mathias Stroobants, Agostinho Carvalho, Patrick Matthys, Lieve Naesens, Katrien Lagrou, Mona Khan,
Publicado en: Science Translational Medicine, Edición 17, 2025, Página(s) eadw9578, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.adw9578

Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis

Autores: Tonia Akoumianaki, Katerina Vaporidi, Eleni Diamantaki, Frédéric Pène, Remi Beau, Mark S. Gresnigt, Marina Gkountzinopulou, Maria Venichaki, Elias Drakos, Jamel El-Benna, George Samonis, Kieu T.T. Le, Vinod Kumar, Dimitrios Georgopoulos, Frank L. van de Veerdonk, Mihai G. Netea, Jean-Paul Latge, Georgios Chamilos
Publicado en: Cell Host & Microbe, Edición S1931-3128(21)00280-8., 2021, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2021.06.002

Metabolic regulation of the host–fungus interaction: from biological principles to therapeutic opportunities

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Publicado en: Journal of Leukocyte Biology, Edición 116, 2024, Página(s) 469-486, ISSN 1938-3673
Editor: Oxford University Press (OUP)
DOI: 10.1093/jleuko/qiae045

SARS-CoV-2 Infection is Associated with Age- and Gender-Specific Changes in the Nasopharyngeal Microbiome

Autores: Silvia Bozza, Emilia Nunzi, Abel Frias-Mazuecos, Giuseppe Pieraccini , Marilena Pariano , Giorgia Renga, Antonella Mencacci, Vincenzo Nicola Talesa, Cinzia Antognelli, Paolo Puccetti, Luigina Romani, Claudio Costantini.
Publicado en: Front Biosci, 2024, Página(s) 29:59, ISSN 1093-9946
Editor: Frontiers in Bioscience
DOI: 10.31083/j.fbl2902059

A High-Risk Profile for Invasive Fungal Infections Is Associatedwith Altered Nasal Microbiota and Niche Determinants

Autores: Claudio Costantini, Emilia Nunzi, Angelica Spolzino, Francesco Merli, Luca Facchini, Antonio Spadea, Lorella Melillo, Katia Codeluppi, Francesco Marchesi, Gessica Marchesini, Daniela Valente, Giulia Dragonetti, Gianpaolo Nadali, Lukas Englmaier, Katerina Coufalikova, Zdeněk Spáčil, Marina Maria Bellet, Marilena Pariano, Giorgia Renga, Claudia Stincardini, Fiorella D'Onofrio,
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Editor: American Society for Microbiology
DOI: 10.1128/iai.00048-22

Host albumin redirects Candida albicans metabolism to engage an alternative pathogenicity pathway

Autores: Sophia U. J. Hitzler, Candela Fernández-Fernández, Kerstin Günther, Axel Dietschmann, Hrant Hovhannisyan, Anna Möslinger, Sophie Austermeier, Beatriz Cristóvão, Gianluca Vascelli, Teresa Zelante, Marina Pekmezović, Bernardo Ramírez-Zavala, Joachim Morschhäuser, Oliver Werz, Toni Gabaldón, Paul M. Jordan, Slavena Vylkova, Mark S. Gresnigt
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Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-61701-5

Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus

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Publicado en: Nature Communications, Edición 12/1, 2021, Página(s) 3739, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-24021-y

A synthetic peptide mimic kills Candida albicans and synergistically prevents infection

Autores: Sebastian Schaefer, Raghav Vij, Jakob L. Sprague, Sophie Austermeier, Hue Dinh, Peter R. Judzewitsch, Sven Müller-Loennies, Taynara Lopes Silva, Eric Seemann, Britta Qualmann, Christian Hertweck, Kirstin Scherlach, Thomas Gutsmann, Amy K. Cain, Nathaniel Corrigan, Mark S. Gresnigt, Cyrille Boyer, Megan D. Lenardon, Sascha Brunke
Publicado en: Nature Communications, Edición 15, 2024, Página(s) 6818, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-50491-x

Integrating genetic and immune factors to uncover pathogenetic mechanisms of viral-associated pulmonary aspergillosis

Autores: Gonçalves SM, Pereira I, Feys S, Cunha C, Chamilos G, Hoenigl M, Wauters J, van de Veerdonk FL, Carvalho A
Publicado en: mBio, Edición 15(6), 2024, Página(s) e0198223, ISSN 2150-7511
Editor: Washington, D.C. American Society for Microbiology
DOI: 10.1128/mbio.01982-23

Albumin orchestrates a natural host defense mechanism against mucormycosis

Autores: Antonis Pikoulas, Ioannis Morianos, Vassilis Nidris Nidris, Rania Hamdy, Ángeles López-López, Maria Moran-Garrido, Valliappan Muthu, Maria Halabalaki, Maria Papadovasilaki, Kyrmizi Irene, Yiyou Gu, Robina Aerts, Toine Mercier, Yuri Vanbiervliet, Sung-Yeon Cho, Amy Spallone, Dimitrios Samonakis, Efstathios Kastritis, Elias Drakos, Maria Tzardi, Aristides Eliopoulos, Konstantina Georgila, Agostin
Publicado en: Res Sq (preprint), Edición Dec 3:rs.3.rs-5441197, 2026, ISSN 2693-5015
Editor: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-5441197/v1

Profiling Bacteria in the Lungs of Patients with Severe Influenza Versus COVID-19 with or without Aspergillosis

Autores: Feys S, Cardinali-Benigni M, Lauwers HM, Jacobs C, Stevaert A, Gonçalves SM, Cunha C, Debaveye Y, Hermans G, Heylen J, Humblet-Baron S, Lagrou K, Maessen L, Meersseman P, Peetermans M, Redondo-Rios A, Seldeslachts L, Starick MR, Thevissen K, Vande Velde G, Vandenbriele C, Vanderbeke L, Wilmer A, Naesens L, van de Veerdonk FL, Van Weyenbergh J, Gabaldón T, Wauters J, Carvalho A.
Publicado en: American Journal of Respiratory and Critical Care Medicine, Edición Epub ahead of print, 2024, ISSN 1073-449X
Editor: American Thoracic Society
DOI: 10.1164/rccm.202401-0145oc

In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence

Autores: Zoe K. Ross, Sakinah Alsayegh, Yixin Zhao, Steven McPherson, Carol A. Munro, Alexander Lorenz
Publicado en: Microbiological Research, Edición 301, 2026, Página(s) 128322, ISSN 0944-5013
Editor: Elsevier BV
DOI: 10.1016/j.micres.2025.128322

Editorial: Advancements in the understanding of Mucorales biology and the management of mucormycosis

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Publicado en: Frontiers in Cellular and Infection Microbiology, Edición 14, 2024, Página(s) 1427252, ISSN 2235-2988
Editor: Frontiers Media S. A.
DOI: 10.3389/fcimb.2024.1427252

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