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FLAGELLIN AEROSOL THERAPY AS AN IMMUNOMODULATORY ADJUNCT TO THE ANTIBIOTIC TREATMENT OF DRUG-RESISTANT BACTERIAL PNEUMONIA

Project description

Flagellin aerosol therapy in treatment of drug-resistant bacterial pneumonia

Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Standard care with antibiotics is often complicated by antimicrobial resistance (AMR), resulting in curative failure. The EU-funded FAIR project aims to assess an adjunct to antibiotic therapy as an emerging concept to overcome AMR in pneumonia. The research focuses on the unique immunomodulator flagellin that enhances airway epithelial innate immune defences, and the development of airway-specific aerosol delivery by nebulisation. FAIR's main objectives include optimisation of nebulisation and demonstration of flagellin-associated enhancement of the antibiotic response, as well as obtaining pharmacokinetics and pharmacodynamics models for clinical validation and assessing flagellin nebulisation safety in a Phase I clinical trial.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /natural sciences/biological sciences/microbiology/bacteriology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance

Call for proposal

H2020-SC1-2019-Two-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 3 701 150

Participants (10)

INSERM TRANSFERT SA
France
EU contribution
€ 300 750
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FREIE UNIVERSITAET BERLIN
Germany
EU contribution
€ 567 750
Address
Kaiserswerther Strasse 16-18
14195 Berlin
Activity type
Higher or Secondary Education Establishments
EPITHELIX SARL
Switzerland
EU contribution
€ 496 000
Address
Chemin Des Aulx 14
1228 Plan Les Ouates
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AEROGEN LTD
Ireland
EU contribution
€ 210 687,50
Address
Ida Business Park Dangan
H91 Galway
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STATENS SERUM INSTITUT
Denmark
EU contribution
€ 2 057 770
Address
Artillerivej 5
2300 Kobenhavn S
Activity type
Research Organisations
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS
France
EU contribution
€ 644 940
Address
Boulevard Tonelle 2
37044 Tours Cedex 9
Activity type
Higher or Secondary Education Establishments
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 1 200 170
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE LILLE
France
EU contribution
€ 380 687,50
Address
42 Rue Paul Duez
59800 Lille
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 367 186,25
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
EUROPEAN RESPIRATORY SOCIETY
Switzerland
EU contribution
€ 235 812,50
Address
Avenue Sainte Luce 4
1003 Lausanne
Activity type
Other