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FLAGELLIN AEROSOL THERAPY AS AN IMMUNOMODULATORY ADJUNCT TO THE ANTIBIOTIC TREATMENT OF DRUG-RESISTANT BACTERIAL PNEUMONIA

Project description

Flagellin aerosol therapy in treatment of drug-resistant bacterial pneumonia

Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Standard care with antibiotics is often complicated by antimicrobial resistance (AMR), resulting in curative failure. The EU-funded FAIR project aims to assess an adjunct to antibiotic therapy as an emerging concept to overcome AMR in pneumonia. The research focuses on the unique immunomodulator flagellin that enhances airway epithelial innate immune defences, and the development of airway-specific aerosol delivery by nebulisation. FAIR's main objectives include optimisation of nebulisation and demonstration of flagellin-associated enhancement of the antibiotic response, as well as obtaining pharmacokinetics and pharmacodynamics models for clinical validation and assessing flagellin nebulisation safety in a Phase I clinical trial.

Call for proposal

H2020-SC1-BHC-2018-2020

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Sub call

H2020-SC1-2019-Two-Stage-RTD

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution
€ 2 321 074,66
Address
Rue De Tolbiac 101
75654 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00

Participants (14)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
Net EU contribution
€ 770 750,34
Address
Rue Leblanc 25
75015 Paris 15

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITE DE TOURS
France
Net EU contribution
€ 149 325,00
Address
Rue Du Plat D Etain 60
37020 Tours

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Region
Centre — Val de Loire Centre — Val de Loire Indre-et-Loire
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

INSTITUT PASTEUR DE LILLE FONDATION
France
Net EU contribution
€ 460 000,00
Address
Rue Du Professeur Calmette 1
59019 Lille

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Region
Hauts-de-France Nord-Pas de Calais Nord
Activity type
Research Organisations
Other funding
€ 0,00
INSERM TRANSFERT SA
France
Net EU contribution
€ 300 750,00
Address
Rue Watt 7
75013 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
FREIE UNIVERSITAET BERLIN
Germany
Net EU contribution
€ 567 750,00
Address
Kaiserswerther Strasse 16-18
14195 Berlin

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
EPITHELIX SARL
Switzerland
Net EU contribution
€ 496 000,00
Address
Chemin Des Aulx 14
1228 Plan Les Ouates

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schweiz/Suisse/Svizzera Région lémanique Genève
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
AEROGEN LTD
Ireland
Net EU contribution
€ 210 687,50
Address
Ida Business Park Dangan
H91 Galway

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ireland Eastern and Midland Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
STATENS SERUM INSTITUT
Denmark
Net EU contribution
€ 2 057 770,00
Address
Artillerivej 5
2300 Kobenhavn S

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Region
Danmark Hovedstaden Byen København
Activity type
Research Organisations
Other funding
€ 0,00
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS
France
Net EU contribution
€ 644 940,00
Address
Boulevard Tonelle 2
37044 Tours Cedex 9

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Region
Centre — Val de Loire Centre — Val de Loire Indre-et-Loire
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
Net EU contribution
€ 1 292 920,00
Address
Meibergdreef 15
1105AZ Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITE DE LILLE
France
Net EU contribution
€ 287 937,50
Address
42 Rue Paul Duez
59000 Lille

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Region
Hauts-de-France Nord-Pas de Calais Nord
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITY OF SOUTHAMPTON
United Kingdom
Net EU contribution
€ 367 186,25
Address
Highfield
SO17 1BJ Southampton

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Region
South East (England) Hampshire and Isle of Wight Southampton
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
EUROPEAN RESPIRATORY SOCIETY
Switzerland
Net EU contribution
€ 122 062,50
Address
Avenue Sainte Luce 4
1003 Lausanne

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Other
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

EUROPEAN LUNG FOUNDATION
United Kingdom
Net EU contribution
€ 113 750,00
Address
Glossop Road 442
S10 2PX Sheffield

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Region
Yorkshire and the Humber South Yorkshire Sheffield
Activity type
Other
Other funding
€ 0,00