FLAGELLIN AEROSOL THERAPY AS AN IMMUNOMODULATORY ADJUNCT TO THE ANTIBIOTIC TREATMENT OF DRUG-RESISTANT BACTERIAL PNEUMONIA
Project information
FAIR
Grant agreement ID: 847786
Status
Ongoing project
-
Start date
1 January 2020
-
End date
31 December 2024
Funded under:
H2020-EU.3.1.3.
-
Overall budget:
€ 10 162 903,75
-
EU contribution
€ 10 162 903,75
Project description
Flagellin aerosol therapy in treatment of drug-resistant bacterial pneumonia
Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Standard care with antibiotics is often complicated by antimicrobial resistance (AMR), resulting in curative failure. The EU-funded FAIR project aims to assess an adjunct to antibiotic therapy as an emerging concept to overcome AMR in pneumonia. The research focuses on the unique immunomodulator flagellin that enhances airway epithelial innate immune defences, and the development of airway-specific aerosol delivery by nebulisation. FAIR's main objectives include optimisation of nebulisation and demonstration of flagellin-associated enhancement of the antibiotic response, as well as obtaining pharmacokinetics and pharmacodynamics models for clinical validation and assessing flagellin nebulisation safety in a Phase I clinical trial.
Programme(s)
Funding Scheme
RIA - Research and Innovation action
Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU Contribution
€ 3 701 150
Participants (10)
INSERM TRANSFERT SA
France
EU Contribution
€ 300 750
FREIE UNIVERSITAET BERLIN
Germany
EU Contribution
€ 567 750
EPITHELIX SARL
Switzerland
EU Contribution
€ 496 000
AEROGEN LTD
Ireland
EU Contribution
€ 210 687,50
STATENS SERUM INSTITUT
Denmark
EU Contribution
€ 2 057 770
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS
France
EU Contribution
€ 644 940
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU Contribution
€ 1 200 170
UNIVERSITE DE LILLE
France
EU Contribution
€ 380 687,50
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU Contribution
€ 367 186,25
EUROPEAN RESPIRATORY SOCIETY
Switzerland
EU Contribution
€ 235 812,50
Project information
FAIR
Grant agreement ID: 847786
Status
Ongoing project
-
Start date
1 January 2020
-
End date
31 December 2024
Funded under:
H2020-EU.3.1.3.
-
Overall budget:
€ 10 162 903,75
-
EU contribution
€ 10 162 903,75
Project information
FAIR
Grant agreement ID: 847786
Status
Ongoing project
-
Start date
1 January 2020
-
End date
31 December 2024
Funded under:
H2020-EU.3.1.3.
-
Overall budget:
€ 10 162 903,75
-
EU contribution
€ 10 162 903,75
Project information
FAIR
Grant agreement ID: 847786
Status
Ongoing project
-
Start date
1 January 2020
-
End date
31 December 2024
Funded under:
H2020-EU.3.1.3.
-
Overall budget:
€ 10 162 903,75
-
EU contribution
€ 10 162 903,75
Project information
FAIR
Grant agreement ID: 847786
Status
Ongoing project
-
Start date
1 January 2020
-
End date
31 December 2024
Funded under:
H2020-EU.3.1.3.
-
Overall budget:
€ 10 162 903,75
-
EU contribution
€ 10 162 903,75
Deliverables
Deliverables not available
Publications
Publications not available
Project information
FAIR
Grant agreement ID: 847786
Status
Ongoing project
-
Start date
1 January 2020
-
End date
31 December 2024
Funded under:
H2020-EU.3.1.3.
-
Overall budget:
€ 10 162 903,75
-
EU contribution
€ 10 162 903,75
Project information
FAIR
Grant agreement ID: 847786
Status
Ongoing project
-
Start date
1 January 2020
-
End date
31 December 2024
Funded under:
H2020-EU.3.1.3.
-
Overall budget:
€ 10 162 903,75
-
EU contribution
€ 10 162 903,75
Project information
FAIR
Grant agreement ID: 847786
Status
Ongoing project
-
Start date
1 January 2020
-
End date
31 December 2024
Funded under:
H2020-EU.3.1.3.
-
Overall budget:
€ 10 162 903,75
-
EU contribution
€ 10 162 903,75
