CORDIS
EU research results

CORDIS

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FLAGELLIN AEROSOL THERAPY AS AN IMMUNOMODULATORY ADJUNCT TO THE ANTIBIOTIC TREATMENT OF DRUG-RESISTANT BACTERIAL PNEUMONIA

Project information

Grant agreement ID: 847786

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2024

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 10 162 903,75

  • EU contribution

    € 10 162 903,75

Coordinated by:

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Project description

English EN

Flagellin aerosol therapy in treatment of drug-resistant bacterial pneumonia

Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Standard care with antibiotics is often complicated by antimicrobial resistance (AMR), resulting in curative failure. The EU-funded FAIR project aims to assess an adjunct to antibiotic therapy as an emerging concept to overcome AMR in pneumonia. The research focuses on the unique immunomodulator flagellin that enhances airway epithelial innate immune defences, and the development of airway-specific aerosol delivery by nebulisation. FAIR's main objectives include optimisation of nebulisation and demonstration of flagellin-associated enhancement of the antibiotic response, as well as obtaining pharmacokinetics and pharmacodynamics models for clinical validation and assessing flagellin nebulisation safety in a Phase I clinical trial.

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Address

Rue De Tolbiac 101
75654 Paris

France

Activity type

Research Organisations

EU Contribution

€ 3 701 150

Participants (10)

INSERM TRANSFERT SA

France

EU Contribution

€ 300 750

FREIE UNIVERSITAET BERLIN

Germany

EU Contribution

€ 567 750

EPITHELIX SARL

Switzerland

EU Contribution

€ 496 000

AEROGEN LTD

Ireland

EU Contribution

€ 210 687,50

STATENS SERUM INSTITUT

Denmark

EU Contribution

€ 2 057 770

CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS

France

EU Contribution

€ 644 940

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

EU Contribution

€ 1 200 170

UNIVERSITE DE LILLE

France

EU Contribution

€ 380 687,50

UNIVERSITY OF SOUTHAMPTON

United Kingdom

EU Contribution

€ 367 186,25

EUROPEAN RESPIRATORY SOCIETY

Switzerland

EU Contribution

€ 235 812,50

Project information

Grant agreement ID: 847786

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2024

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 10 162 903,75

  • EU contribution

    € 10 162 903,75

Coordinated by:

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France