FLAGELLIN AEROSOL THERAPY AS AN IMMUNOMODULATORY ADJUNCT TO THE ANTIBIOTIC TREATMENT OF DRUG-RESISTANT BACTERIAL PNEUMONIA

Project description

Flagellin aerosol therapy in treatment of drug-resistant bacterial pneumonia

Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Standard care with antibiotics is often complicated by antimicrobial resistance (AMR), resulting in curative failure. The EU-funded FAIR project aims to assess an adjunct to antibiotic therapy as an emerging concept to overcome AMR in pneumonia. The research focuses on the unique immunomodulator flagellin that enhances airway epithelial innate immune defences, and the development of airway-specific aerosol delivery by nebulisation. FAIR's main objectives include optimisation of nebulisation and demonstration of flagellin-associated enhancement of the antibiotic response, as well as obtaining pharmacokinetics and pharmacodynamics models for clinical validation and assessing flagellin nebulisation safety in a Phase I clinical trial.

Fields of science

• medical and health sciences › health sciences › public and environmental health
• natural sciences › biological sciences › microbiology › bacteriology
• medical and health sciences › basic medicine › pharmacology and pharmacy › drug resistance › antibiotic resistance

Programme(s)

• H2020-EU.3.1.3. - Treating and managing disease

Topic(s)

• SC1-BHC-14-2019 - Stratified host-directed approaches to improve prevention, treatment and/or cure of infectious diseases

Call for proposal

H2020-SC1-2019-Two-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Address

Rue De Tolbiac 101
75654 Paris
France

Activity type

Research Organisations

EU contribution

€ 3 701 150

Participants (10)

INSERM TRANSFERT SA

France

EU contribution

€ 300 750

Address

Rue Watt 7
75013 Paris

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

FREIE UNIVERSITAET BERLIN

Germany

EU contribution

€ 567 750

Address

Kaiserswerther Strasse 16-18
14195 Berlin

Activity type

Higher or Secondary Education Establishments

EPITHELIX SARL

Switzerland

EU contribution

€ 496 000

Address

Chemin Des Aulx 14
1228 Plan Les Ouates

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

AEROGEN LTD

Ireland

EU contribution

€ 210 687,50

Address

Ida Business Park Dangan
H91 Galway

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

STATENS SERUM INSTITUT

Denmark

EU contribution

€ 2 057 770

Address

Artillerivej 5
2300 Kobenhavn S

Activity type

Research Organisations

CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS

France

EU contribution

€ 644 940

Address

Boulevard Tonelle 2
37044 Tours Cedex 9

Activity type

Higher or Secondary Education Establishments

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

EU contribution

€ 1 292 920

Address

Meibergdreef 15
1105AZ Amsterdam

Activity type

Higher or Secondary Education Establishments

UNIVERSITE DE LILLE

France

EU contribution

€ 287 937,50

Address

42 Rue Paul Duez
59800 Lille

Activity type

Higher or Secondary Education Establishments

UNIVERSITY OF SOUTHAMPTON

United Kingdom

EU contribution

€ 367 186,25

Address

Highfield
SO17 1BJ Southampton

Activity type

Higher or Secondary Education Establishments

EUROPEAN RESPIRATORY SOCIETY

Switzerland

EU contribution

€ 235 812,50

Address

Avenue Sainte Luce 4
1003 Lausanne

Activity type

Other