Prevention and Remediation of Insulin Multimorbidity in Europe

Deliverables

Report on familial co-aggregation of insulin-related morbidities and compulsivity disorders in a multi-generational nationwide cohort study

Report on familial coaggregation of insulinrelated morbidities and compulsivity disorders in a multigenerational nationwide cohort study

Report on incidence, risk, time trends and lifetime course of compulsive and (non-compulsive) brain disorders in Danish individuals with and without insulin-related morbidities

Report on incidence risk time trends and lifetime course of compulsive and noncompulsive brain disorders in Danish individuals with and without insulinrelated morbidities

Report on comorbidity of compulsivity, learning difficulties, and diabetes in TALLYHO mice

Report on comorbidity of compulsivity learning difficulties and diabetes in TALLYHO mice

Communication and outreach plan
Report on epigenetic analysis of insulinopathies
Report on the genetic overlap between somatic and neurodegenerative brain insulinopathies and related traits
Report on the effect of insulin signalling markers on cognitive impairment and AD biomarkers
Report on the association of compulsive traits and/or cognitive rigidity with insulin signalling markers and/or somatic insulin-related disorders in participants of the UK Biobank

Report on the association of compulsive traits andor cognitive rigidity with insulin signalling markers andor somatic insulinrelated disorders in participants of the UK Biobank

Campfire Session at ECNP Congress

Go-online of the public project website

Goonline of the public project website

Publications

Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis (ru.nl)

Author(s): Jorim J.Tielbeek et al.
Published in: Molecular Psychiatry, 2021, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-022-01793-3

The translational genetics of ADHD and related phenotypes inmodel organisms

Author(s): Judit Cabana-Domínguez, Ester Antón-Galindo, Noèlia Fernàndez-Castillo, Euginia L Singgih, Aet O'Leary, William Hg Norton, Tatyana Strekalova, Annette Schenck , Andreas Reif, Klaus-Peter Lesch, David Slattery , Bru Cormand
Published in: Neuroscience and Biobehavioural Review, 2023, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2022.104949

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

Author(s): Joanna Martin; Ekaterina A. Khramtsova; Slavina B. Goleva; Gabriëlla A.M. Blokland; Michela Traglia; Raymond K. Walters; Christopher Hübel; Jonathan R.I. Coleman; Gerome Breen; Anders D. Børglum; Ditte Demontis; Jakob Grove; Thomas Werge; Janita Bralten; Cynthia M. Bulik; Phil H. Lee; Carol A. Mathews; Roseann E. Peterson; Stacey J. Winham; Naomi Wray; Howard J. Edenberg; Wei Guo; Yin Yao; Benj
Published in: Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium 2021 , ' Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits ' , Biological Psychiatry . https://doi.org/10.1016/j.biopsych.2020.12.024, Issue 1, 2021, Page(s) 1127-1137, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1101/2020.05.04.076042

Interplay between cognition and weight reduction in individuals following a Mediterranean Diet: Three-year follow-up of the PREDIMED-Plus trial.

Author(s): Natalia Soldevila-Domenech; Laura Forcano; Cristina Vintró-Alcaraz; Aida Cuenca-Royo; Xavier Pintó; Susana Jiménez-Murcia; Jesús García-Gavilán; Stephanie K. Nishi; Nancy Babio; Maria Gomis-González; Dolores Corella; Dolores Corella; José V. Sorlí; José V. Sorlí; Rebeca Fernández-Carrión; Rebeca Fernández-Carrión; Miguel Ángel Martínez-González; Amelia Marti; Amelia Marti; Jordi
Published in: Clinical Nutritions, Issue 10, 2021, ISSN 0261-5614
Publisher: Churchill Livingstone
DOI: 10.1016/j.clnu.2021.07.020

Temporally ordered associations between type 2 diabetes and brain disorders - a Danish register-based cohort study

Author(s): Theresa Wimberley; Henriette T. Horsdal; Isabell Brikell; Thomas M. Laursen; Aske Astrup; Giuseppe Fanelli; Janita Bralten; Geert Poelmans; Veerle Van Gils; Willemijn J. Jansen; Stephanie J. B. Vos; Valérie Bertaina-Anglade; Lucia Camacho-Barcia; Bernat Mora-Maltas; Fernando Fernandez-Aranda; Mònica B. Bonet; Jordi Salas-Salvadó; Barbara Franke; Søren Dalsgaard
Published in: VOLUME=22;ISSUE=1;ISSN=1471-244X;TITLE=BMC Psychiatry, Issue 2, 2022, ISSN 1471-244X
Publisher: BioMed Central
DOI: 10.1186/s12888-022-04163-z

Metformin Use and Cognitive Function in Older Adults With Type 2 Diabetes Following a Mediterranean Diet Intervention

Author(s): Natalia Soldevila-Domenech; Natalia Soldevila-Domenech; Aida Cuenca-Royo; Nancy Babio; Nancy Babio; Laura Forcano; Laura Forcano; Stephanie Nishi; Stephanie Nishi; Cristina Vintró-Alcaraz; Cristina Vintró-Alcaraz; Cristina Vintró-Alcaraz; Carlos Gómez-Martínez; Carlos Gómez-Martínez; Susana Jiménez-Murcia; Susana Jiménez-Murcia; Susana Jiménez-Murcia; Susana Jiménez-Murcia; Rebeca Fern
Published in: Frontiers in nutrition, Issue 9, 2021, ISSN 2296-861X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fnut.2021.742586

Effects of a psychosocial intervention at one-year follow-up in a PREDIMED-plus sample with obesity and metabolic syndrome

Author(s): Núria Mallorquí-Bagué, María Lozano-Madrid, Cristina Vintró-Alcaraz, Laura Forcano, Andrés Díaz-López, Ana Galera, Rebeca Fernández-Carrión, Roser Granero, Susana Jiménez-Murcia, Dolores Corella, Xavier Pintó, Aida Cuenca-Royo, Mònica Bulló, Jordi Salas-Salvadó, Rafael de la Torre, Fernando Fernández-Aranda
Published in: Scientific Reports, Issue 11/1, 2021, Page(s) Sci Rep 11, 9144, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-88298-1

Emotional regulation in eating disorders and gambling disorder: A transdiagnostic approach

Author(s): Lucero Munguía, Susana Jiménez-Murcia, Roser Granero, Isabel Baenas, Zaida Agüera, Isabel Sánchez, Ester Codina, Amparo del Pino-Gutiérrez, Guilia Testa, Janet Treasure, Fernando Fernández-Aranda
Published in: Journal of Behavioral Addictions, Issue 2063-5303, 2021, Page(s) 2063-5303, ISSN 2062-5871
Publisher: Akademiai Kiado
DOI: 10.1556/2006.2021.00017

Transdiagnostic Perspective of Impulsivity and Compulsivity in Obesity: From Cognitive Profile to Self-Reported Dimensions in Clinical Samples with and without Diabetes

Author(s): Testa G. et al.
Published in: Nutrients, 2021, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13124426

Impulsive personality traits predicted weight loss in individuals with type 2 diabetes after 3 years of lifestyle interventions

Author(s): Giulia Testa; Lucía Camacho-Barcia; Carlos Gómez-Martínez; Bernat Mora-Maltas; Rafael de la Torre; Xavier Pintó; Dolores Corella; Roser Granero; Aida Cuenca-Royo; Susana Jiménez-Murcia; Nancy Babio; Rebeca Fernández-Carrión; Virginia Esteve-Luque; Laura Forcano; Jiaqi Ni; Mireia Malcampo; Sara De las Heras-Delgado; Montse Fitó; Jordi Salas-Salvadó; Fernando Fernández-Aranda
Published in: Journal of Clinical medicine, Issue 2, 2022, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11123476

Dairy Product Consumption and Changes in Cognitive Performance: Two-Year Analysis of the PREDIMED-Plus Cohort

Author(s): Stephanie Nishi; Itziar Salaverría Lete; Rosa Casas; Helmut Schroder; Miguel A. Martinez-Gonzalez; Carolina Donat; Jordi Salas-Salvadó; Alice Chaplin; Carlos Gómez Martínez; Jesus Vioque; Jiaqi Ni
Published in: Molecular nutrition and food research, Issue 8, 2022, ISSN 1613-4125
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202101058

Impulsivity is longitudinally associated with healthy and unhealthy dietary patterns in individuals with overweight or obesity and metabolic syndrome within the framework of the PREDIMED-Plus trial

Author(s): Carlos Gómez-Martínez; Nancy Babio; Jordi Júlvez; Stephanie K. Nishi; Fernando Fernández-Aranda; Miguel Ángel Martínez-González; Aida Cuenca-Royo; Rebeca Fernández; Susana Jiménez-Murcia; Rafael de la Torre; Xavier Pintó; Mirjam Bloemendaal; Montse Fitó; Dolores Corella; Alejandro Arias; Jordi Salas-Salvadó
Published in: Int J Behav Nutr Phys Act., Issue 3, 2022, Page(s) 101, ISSN 1479-5868
Publisher: BioMed Central
DOI: 10.1186/s12966-022-01335-8

The link between cognition and somatic conditions related to insulin resistance in the UK Biobank study cohort: a systematic review

Author(s): Giuseppe Fanelli, Nina Roth Mota, Jordi Salas-Salvadó, Mònica Bulló, Fernando Fernandez-Aranda, Lucía Camacho-Barcia, Giulia Testa, Susana Jiménez-Murcia, Valérie Bertaina-Anglade, Barbara Franke, Geert Poelmans, Veerle van Gils, Willemijn J Jansen, Stephanie J B Vos, Theresa Wimberley, Søren Dalsgaard, Csaba Barta, Alessandro Serretti, Chiara Fabbri, Janita Bralten
Published in: Neuroscience and Biobehavioural Review, 2022, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2022.104927

Annual Research Review: Perspectives on progress in ADHD science – from characterization to cause

Author(s): Edmund J.S. Sonuga-Barke, Stephen P. Becker, Sven Bölte, Francisco Xavier Castellanos, Barbara Franke, Jeffrey H. Newcorn, Joel T. Nigg, Luis Augusto Rohde, Emily Simonoff
Published in: Journal of Child Psychology and Psychiatry, Issue n.a., 2022, Page(s) n/a - n/a, ISSN 0021-9630
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jcpp.13696

Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling

Author(s): Janita Bralten, Joanna Widomska, Ward De Witte, Dongmei Yu, Carol A. Mathews, Jeremiah M. Scharf, Jan Buitelaar, Jennifer Crosbie, Russell Schachar, Paul Arnold, Mathieu Lemire, Christie L. Burton, Barbara Franke, Geert Poelmans
Published in: Translational Psychiatry, Issue 10/1, 2020, Page(s) 121, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-020-0793-y

Mediterranean, DASH, and MIND Dietary Patterns and Cognitive Function: The 2-Year Longitudinal Changes in an Older Spanish Cohort

Author(s): Stephanie K. Nishi; Stephanie K. Nishi; Stephanie K. Nishi; Stephanie K. Nishi; Stephanie K. Nishi; Nancy Babio; Nancy Babio; Nancy Babio; Nancy Babio; Carlos Gómez-Martínez; Carlos Gómez-Martínez; Carlos Gómez-Martínez; Miguel Ángel Martínez-González; Miguel Ángel Martínez-González; Miguel Ángel Martínez-González; Emilio Ros; Emilio Ros; Dolores Corella; Dolores Corella; Olga Casta
Published in: Neurocognitive Aging and Behavior, Issue 6, 2021, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2021.782067

Metabolic, Affective and Neurocognitive Characterization of Metabolic Syndrome Patients with and without Food Addiction. Implications for Weight Progression

Author(s): Lucía Camacho-Barcia, Lucero Munguía, Ignacio Lucas, Rafael de la Torre, Jordi Salas-Salvadó, Xavier Pintó, Dolores Corella, Roser Granero, Susana Jiménez-Murcia, Inmaculada González-Monje, Virginia Esteve-Luque, Aida Cuenca-Royo, Carlos Gómez-Martínez, Indira Paz-Graniel, Laura Forcano, Fernando Fernández-Aranda
Published in: Nutrients, Issue 13/8, 2021, Page(s) 2779, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13082779

Glycemic Dysregulations Are Associated With Worsening Cognitive Function in Older Participants at High Risk of Cardiovascular Disease: Two-Year Follow-up in the PREDIMED-Plus Study.

Author(s): Carlos Gómez-Martínez; Carlos Gómez-Martínez; Carlos Gómez-Martínez; Nancy Babio; Nancy Babio; Nancy Babio; Nancy Babio; Jordi Júlvez; Nerea Becerra-Tomás; Nerea Becerra-Tomás; Nerea Becerra-Tomás; Miguel Á. Martínez-González; Miguel Á. Martínez-González; Miguel Á. Martínez-González; Dolores Corella; Dolores Corella; Olga Castañer; Olga Castañer; Dora Romaguera; Dora Romaguera
Published in: instname:Universidad de Barcelona, Issue 8, 2021, ISSN 1664-2392
Publisher: Frontiers Media
DOI: 10.3389/fendo.2021.754347

P.169 Genetic overlap between somatic insulin-related and neuro-psychiatric disorders

Author(s): G. Fanelli, F. Barbara, W. De Witte, N.R. Mota, G. Poelmans, J. Bralten
Published in: European Neuropsychopharmacology, Issue 40, 2020, Page(s) S97-S98, ISSN 0924-977X
Publisher: Elsevier BV
DOI: 10.1016/j.euroneuro.2020.09.130

Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders

Author(s): Giuseppe Fanelli, Barbara Franke, Ward De Witte, I. Hyun Ruisch, Jan Haavik, Veerle van Gils, Willemijn J. Jansen, Stephanie J. B. Vos, Lars Lind, Jan K. Buitelaar, Tobias Banaschewski, Søren Dalsgaard, Alessandro Serretti, Nina Roth Mota, Geert Poelmans, Janita Bralten
Published in: 2021
Publisher: medRxiv's
DOI: 10.1101/2021.05.28.21258000

Deliverables

Publications

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