Associative mechanisms linking a defective minipuberty to the appearance of mental and nonmental disorders: infantile NO replenishment as a new therapeutic possibility

Project description

For better treatment of those born prematurely

Individuals born prematurely not only face increased risks as newborns but also suffer from multimorbidity in their later life. This is associated with adaptive changes of the hypothalamic-pituitary-gonadal axis during infancy, but the exact mechanisms underlying its malfunction and its consequences are largely unknown. The EU-funded miniNO project will conduct out pioneering research on the connection between alterations in minipuberty and infantile nitric oxide (NO) signaling in the brain, and comorbidities that appear later in life in prematurely born individuals. The project is based on previous clinical studies and solid data of the collaborating teams. It will create an extensive repertoire of clinical and genetic data, associating minipuberty and brain NO levels with mental and non-mental disorders, having as its main aim the search for explanations and treatments for the health burdens of millions of prematurely born people.

Fields of science

• social sciences › sociology › demography › fertility

Programme(s)

• H2020-EU.3.1.1. - Understanding health, wellbeing and disease

Topic(s)

• SC1-BHC-01-2019 - Understanding causative mechanisms in co- and multimorbidities combining mental and non-mental disorders

Call for proposal

H2020-SC1-2019-Two-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Address

Rue De Tolbiac 101
75654 Paris
France

Activity type

Research Organisations

EU contribution

€ 943 750

Participants (9)

BIOGAZELLE NV

Belgium

EU contribution

€ 499 000

Address

Technologiepark 82
9052 Zwijnaarde

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE

France

EU contribution

€ 742 188,75

Address

Avenue Oscar Lambret 2
59037 Lille

Activity type

Higher or Secondary Education Establishments

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS

Switzerland

EU contribution

€ 1 338 243,75

Address

Rue Du Bugnon 21
1011 Lausanne

Activity type

Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)

INSERM TRANSFERT SA

France

EU contribution

€ 400 375

Address

Rue Watt 7
75013 Paris

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

QUEEN MARY UNIVERSITY OF LONDON

United Kingdom

EU contribution

€ 578 332,50

Address

327 Mile End Road
E1 4NS London

Activity type

Higher or Secondary Education Establishments

UNIVERSITE DE LILLE

France

EU contribution

€ 539 605

Address

42 Rue Paul Duez
59800 Lille

Activity type

Higher or Secondary Education Establishments

UNIVERSITE DE GENEVE

Switzerland

EU contribution

€ 347 750

Address

Rue Du General Dufour 24
1211 Geneve

Activity type

Higher or Secondary Education Establishments

EREVNITIKO PANEPISTIMIAKO INSTITUTOMELETIS KE ANTIMETOPISIS GENETIKONKE KAKOETHON NOSIMATON TIS PEDIKISILIKIAS

Greece

EU contribution

€ 617 500

Address

8 Levadias Street
115 27 Athina

Activity type

Other

UNIVERSITAET zu LUEBECK

Germany

EU contribution

€ 481 025

Address

Ratzeburger Allee 160
23562 Lubeck

Activity type

Higher or Secondary Education Establishments