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Associative mechanisms linking a defective minipuberty to the appearance of mental and nonmental disorders: infantile NO replenishment as a new therapeutic possibility

Project description

For better treatment of those born prematurely

Individuals born prematurely not only face increased risks as newborns but also suffer from multimorbidity in their later life. This is associated with adaptive changes of the hypothalamic-pituitary-gonadal axis during infancy, but the exact mechanisms underlying its malfunction and its consequences are largely unknown. The EU-funded miniNO project will conduct out pioneering research on the connection between alterations in minipuberty and infantile nitric oxide (NO) signaling in the brain, and comorbidities that appear later in life in prematurely born individuals. The project is based on previous clinical studies and solid data of the collaborating teams. It will create an extensive repertoire of clinical and genetic data, associating minipuberty and brain NO levels with mental and non-mental disorders, having as its main aim the search for explanations and treatments for the health burdens of millions of prematurely born people.

Field of science

  • /social sciences/sociology/demography/fertility

Call for proposal

H2020-SC1-2019-Two-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 943 750

Participants (9)

BIOGAZELLE NV
Belgium
EU contribution
€ 499 000
Address
Technologiepark 82
9052 Zwijnaarde
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE
France
EU contribution
€ 742 188,75
Address
Avenue Oscar Lambret 2
59037 Lille
Activity type
Higher or Secondary Education Establishments
CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Switzerland
EU contribution
€ 1 338 243,75
Address
Rue Du Bugnon 21
1011 Lausanne
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
INSERM TRANSFERT SA
France
EU contribution
€ 400 375
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 578 332,50
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE LILLE
France
EU contribution
€ 539 605
Address
42 Rue Paul Duez
59800 Lille
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 347 750
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
EREVNITIKO PANEPISTIMIAKO INSTITUTOMELETIS KE ANTIMETOPISIS GENETIKONKE KAKOETHON NOSIMATON TIS PEDIKISILIKIAS
Greece
EU contribution
€ 617 500
Address
8 Levadias Street
115 27 Athina
Activity type
Other
UNIVERSITAET zu LUEBECK
Germany
EU contribution
€ 481 025
Address
Ratzeburger Allee 160
23562 Lubeck
Activity type
Higher or Secondary Education Establishments