Associative mechanisms linking a defective minipuberty to the appearance of mental and nonmental disorders: infantile NO replenishment as a new therapeutic possibility

Project Information

miniNO

Grant agreement ID: 847941

DOI

10.3030/847941

EC signature date 5 December 2019

Start date 1 January 2020

End date 31 October 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 6 487 770,00

EU contribution

€ 6 487 770,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (1)

Novel transgenic mouse model

Websites, patent fillings, videos etc. (1)

Project website and communication tools

Project visual identity: Logo, templates, .... and project leaflet

Publications

Peer reviewed articles (18)

Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra's seminal work

Author(s): Greg M Anderson, Jennifer W Hill, Ursula B Kaiser, Victor M Navarro, Ken K Ong , John R B Perry, Vincent Prevot, Manuel Tena-Sempere, Carol F Elias
Published in: Nature Review Endocrinology, 2024, ISSN 1759-5037
Publisher: Nature
DOI: 10.1038/s41574-023-00919-z

Dominant monoallelic variant in the PAK2 gene causes Knobloch syndrome type 2

Author(s): Stylianos E Antonarakis, Ales Holoubek, Melivoia Rapti, Jesse Rademaker, Jenny Meylan, Justyna Iwaszkiewicz, Vincent Zoete, Callum Wilson, Juliet Taylor, Muhammad Ansar, Christelle Borel, Olivier Menzel, Kateřina Kuželová, Federico A Santoni
Published in: Human Molecular Genetics, 2021, Page(s) in press, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddab026

The KiNG of reproduction: Kisspeptin/ nNOS interactions shaping hypothalamic GnRH release

Author(s): Virginia Delli, Mauro S.B. Silva, Vincent Prévot, Konstantina Chachlaki
Published in: Molecular and Cellular Endocrinology, Issue 532, 2021, Page(s) 111302, ISSN 0303-7207
Publisher: Elsevier BV
DOI: 10.1016/j.mce.2021.111302

Novel insights into minipuberty and GnRH: Implications on neurodevelopment, cognition, and COVID-19 therapeutics

Author(s): Chachlaki K*, Le Duc K, Storme L, Prevot V*
Published in: Journal of Neuroendocrinology, 2024, ISSN 1365-2826
Publisher: Wiley
DOI: 10.1111/jne.13387

pyTWMR: transcriptome-wide Mendelian randomization in python

Author(s): Sergey Oreshkov, Kaido Lepik, Federico Santoni
Published in: Bioinformatics, Issue 40, 2024, Page(s) online, ISSN 1367-4811
Publisher: Oxford University Press (OUP)
DOI: 10.1093/bioinformatics/btae505

[Minipuberty: A critical period for brain functional development]

Author(s): """ Konstantina Chachlaki, Kevin Le Duc, Laurent Storme, Vincent Prévot"""
Published in: Med Sci (Paris), 2023, ISSN 0767-0974
Publisher: Editions E D K
DOI: 10.1051/medsci/2023113

A role for GnRH in olfaction and cognition: Implications for veterinary medicine

Author(s): Vincent Prévot, Anne Duittoz
Published in: Reprod Domest Anim, 2023, ISSN 0936-6768
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/rda.14411

Male minipuberty involves the gonad-independent activation of preoptic nNOS neurons

Author(s): Virginia Dellia Julien Dehame Delphine Franssen S.Rasika Anne-Simone Parent Vincent Prevot Konstantina Chachlaki
Published in: Free Radical Biology and Medicine, 2022, Page(s) ALL, ISSN 0891-5849
Publisher: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2022.11.040

Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans

Author(s): Edouard G. Mills, Mauro S.B. Silva, Virginia Delli, Laurine Decoster, Gaetan Ternier, Jovanna Tsoutsouki, Layla Thurston, Maria Phylactou, Bijal Patel, Lisa Yang, Sophie A. Clarke, Megan Young, Emma C. Alexander, Sandhi Nyunt, Arthur C. Yeung, Muhammad Choudhury, Anastasia Newman, Paul Bech, Ali Abbara, Magda Swedrowska, Ben Forbes, Vincent Prévot, Konstantina Chachlaki, Paolo Giacobini, Alexande
Published in: eBioMedicine, Issue 115, 2025, Page(s) 105689, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105689

Defective Nitric oxide pathway signalling - a link between premature birth and altered mini-puberty?

Author(s): Jordan Read, Virginia Delli, Leo Dunkel, Federico Santoni, Vincent Prevot, Leonardo Guasti, Konstantina Chachlaki, Sasha Howard
Published in: Endocrine Abstracts, 2025, ISSN 1479-6848
Publisher: Bioscientifica
DOI: 10.1530/endoabs.110.p919

CoverageMaster: comprehensive CNV detection and visualization from NGS short reads for genetic medicine applications

Author(s): Melivoia Rapti, Yassine Zouaghi, Jenny Meylan, Emmanuelle Ranza, Stylianos E Antonarakis, Federico A Santoni 
Published in: Briefings in Bioinformatics, 2019, ISSN 1467-5463
Publisher: Oxford University Press
DOI: 10.1093/bib/bbac049

Risk Factors for Hearing Loss Are Comparable in Preterm Versus Term Children: A Systematic Review

Author(s): Pauline Roehrs, Anna‐Katharina Rohlfs, Reinhard Vonthein, Camilla Simon, Juliane Spiegler
Published in: Acta Paediatrica, Issue 114, 2025, Page(s) 2763-2782, ISSN 0803-5253
Publisher: Taylor & Francis
DOI: 10.1111/apa.70222

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

Author(s): """ Florent Sauve*, Sreekala Nampoothiri*, Sophie A Clarke*, Daniela Fernandois*, Caio Fernando Ferreira Coêlho*, Julie Dewisme, Edouard G Mills, Gaetan Ternier , Ludovica Cotellessa, Cristina Iglesias-Garcia, Helge Mueller-Fielitz, Thibaud Lebouvier, Romain Perbet, Vincent Florent, Marc Baroncini, Ariane Sharif, June Ereño-Orbea, Maria Mercado-Gómez, Asis Palazon, Virginie Mattot, Florence Pasqu"
Published in: EBioMedicine, 2024, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104784

Preventing and correcting polycystic ovary syndrome by targeting anti-Müllerian hormone signaling in minipuberty and adulthood in mice

Author(s): Ludovica Cotellessa, Veronica Sobrino, Mauro S.B. Silva, Maxime Delit, Hélène Maitre, Emilie Caron, Gaëtan Ternier, Natalia da Silva Lima, Tori Lhomme, Frank Giton, Andrea Sorrentino, Laura Carraresi, Giovanna Di Nardo, Ruben Nogueiras, Manuel Tena-Sempere, Vincent Prevot, Paolo Giacobini
Published in: Cell Metabolism, Issue 37, 2026, Page(s) 1260-1276.e8, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2025.03.013

Whole genome sequencing and single-cell transcriptomics identify KMT2D inactivation as a potential new driver for pituitary tumors: a case report

Author(s): Maxime Brunner, Jenny Meylan-Merlini, Maude Muriset, Sergey Oreshkov, Andrea Messina, Mahmoud Messerer, Roy Daniel, Ekkehard Hewer, Jean Phillipe Brouland, Federico Santoni
Published in: BJC Reports, Issue 3, 2025, Page(s) online, ISSN 2731-9377
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44276-025-00155-0

Treatment With Inhaled Nitric Oxide and General Intelligence in Preterm Children in Two European Cohorts

Author(s): Nicole Tsalacopoulos, Valérie Benhammou, Laetitia Marchand‐Martin, Véronique Pierrat, Pierre‐Yves Ancel, Armita Shahesmaeilinejad, Viktoria Rücker, Vincent Prevot, Konstantina Chachlaki, Christoph Härtel, Wolfgang Göpel, Juliane Spiegler, null null
Published in: Acta Paediatrica, Issue 114, 2026, Page(s) 2346-2356, ISSN 0803-5253
Publisher: Taylor & Francis
DOI: 10.1111/apa.70118

NOS1 mutations in humans cause hypogonadotropic hypogonadism with sensory and intellectual comorbidities, reversible experimentally by NO treatment at minipuberty

Author(s): Konstantina Chachlaki, Andrea Messina Virginia Delli Valerie Leysen Csilla Maurnyi Chieko Huber Gaëtan Ternier Katalin Skrapits Georgios Papadakis Sonal Shruti Maria Kapanidou Xu Cheng James Acierno Jesse Rademaker Sowmyalakshmi Rasika Richard Quinton Marek Niedziela Dagmar L’allemand Duarte Pignatelli Mirjam Dirlewander Mariarosaria Lang-Muritano Patrick Kempf Sophie Catteau
Published in: Science Translational Medicine, Issue Vol. 14, 2022, Page(s) all, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abh2369

New Horizons: Gonadotropin-Releasing Hormone and Cognition

Author(s): """Vincent Prévot , Manuel Tena-Sempere, Nelly Pitteloud """
Published in: J Clin Endocrol Metab, 2023, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgad319

Non-peer reviewed articles (1)

Seeing through the fog: a neuroendocrine explanation for post-covid cognitive deficit

Author(s): S Rasika, Ruben Nogueiras, Markus Schwaninger, Vincent Prevot
Published in: Nature Review Endocrinology, 2024, ISSN 1759-5037
Publisher: Nature
DOI: 10.1038/s41574-024-00955-3

Book chapters (1)

Volume Transmission of Neurotransmitters and Neuropeptides in the Brain

Author(s): Betty Rodriguez Cortes, Konstantina Chachlaki, Vincent Prevot
Published in: Masterclass in Neuroendocrinology, Evolutionary and Comparative Neuroendocrinology, 2025, Page(s) 71-100, ISSN 2662-20682662-2076
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-031-80209-6_3