Project description DEENESFRITPL Personalised medicine model for the treatment of advanced colorectal cancer The EU-funded REVERT project will address at systems level the pathophysiology of advanced colorectal cancer in patients responding well or poorly to therapies, with the goal to design an optimal strategy for therapeutic interventions depending on patients' features. This goal will be achieved using a large number of standardised biobank samples and clinical databases from several clinical European centres, including known and new potential prognostic biomarkers. Following the AI-based data analysis, results will be evaluated for the REVERT-DataBase impact on survival and quality of life in prospective clinical trials. The project will also generate a broad network among industrial and academic partners focused on the development of personalised medicine. Show the project objective Hide the project objective Objective The REVERT project will address the specific challenge of understanding at system level the pathophysiology of mCRC cancer in patients responding well or poorly to therapies, in order to design optimal strategy for mCRC on a case by case basis, with therapeutic interventions modulated depending on patient’s features. Accordingly, REVERT will build up an innovative artificial intelligence (AI)-based decision support system using the experience and the real-world data of several general Hospitals operating in the EU healthcare system ultimately aimed at developing an improved and innovative model of combinatorial therapy - based on a personalised medicine approach - that identifies the most efficient and cost-effective therapeutic intervention for patients with unresectable mCRC. This goal will be pursued through the building of the REVERT-DataBase (RDB) thanks to a large number of standardized biobank samples with related structured data, and clinical databases (including known clinical and biological features as well as new, potential prognostic/predictive biomarkers) from several major clinical European centres. The RDB, in turn, will be used to build a sophisticated computational framework based on AI to evaluate its impact on survival and quality of life in a prospective clinical trial through testing of new treatment sequences of the available and authorised molecular targeted drugs in patients with mCRC. In the end, the REVERT will also generate an EU- network among SMEs, Research Institutions, Clinical Centres and Biobanks focused on R&D in the field of AI-Health for the development of personalised medicine.The REVERT software system will ensure the integrity of data and privacy management in respect to national rules, the EU's GDPR (Reg. EU 2016/679) and the EU Charter of Fundamental Rights. The RDB and AI services will be open to all partners during and after project’s completion, available also to EU research Institutions for future studies. Keywords unresectable colorectal cancer new combinatorial therapy database computational framework molecular mechanisms predictive models cancer progression innovative AI-based decision support system Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.1. - Understanding health, wellbeing and disease Topic(s) SC1-BHC-02-2019 - Systems approaches for the discovery of combinatorial therapies for complex disorders Call for proposal H2020-SC1-BHC-2018-2020 See other projects for this call Sub call H2020-SC1-2019-Two-Stage-RTD Funding Scheme RIA - Coordinator IRCCS SAN RAFFAELE ROMA SRL Net EU contribution € 998 125,00 Address Via della pisana 235 00163 Roma rm Italy See on map Region Centro (IT) Lazio Roma Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (22) Sort alphabetically Sort by Net EU contribution Expand all Collapse all AZIENDA ULSS 4 VENETO ORIENTALE Italy Net EU contribution € 200 541,25 Address Piazza de gasperi 5 30027 San dona di piave See on map Region Nord-Est Veneto Venezia Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MALMO UNIVERSITET Sweden Net EU contribution € 399 420,00 Address Nordenskioldsgatan 1 205 06 Malmoe See on map Region Södra Sverige Sydsverige Skåne län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 GENXPRO GMBH Germany Net EU contribution € 443 750,00 Address Altenhofter allee 3 60438 Frankfurt See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG Germany Net EU contribution € 150 000,00 Address Unter den eichen 87 12205 Berlin See on map Region Berlin Berlin Berlin Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UMEA UNIVERSITET Sweden Net EU contribution € 325 750,00 Address Universitetomradet 901 87 Umea See on map Region Norra Sverige Övre Norrland Västerbottens län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BIOVARIANCE GMBH Germany Net EU contribution € 248 500,00 Address Kornbuhlstrasse 28 95643 Tirschenreuth See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Bayern Oberpfalz Tirschenreuth Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FUNDACION UNIVERSITARIA SAN ANTONIO Spain Net EU contribution € 298 250,00 Address Avda jeronimos campus universi s/n universidad catolica san antonio 30107 Murcia See on map Region Sur Región de Murcia Murcia Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INSTITUTUL REGIONAL DE ONCOLOGIE IASI Romania Net EU contribution € 237 187,50 Address G-ral henri mathias berthelot nr 2-4 700483 Iasi See on map Region Macroregiunea Doi Nord-Est Iaşi Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SERVICIO MURCIANO DE SALUD Spain Net EU contribution € 334 500,00 Address C central 7 30100 Murcia See on map Region Sur Región de Murcia Murcia Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. FUNDACION PARA LA FORMACION E INVESTIGACION SANITARIAS DE LA REGION DE MURCIA Spain Net EU contribution € 8 750,00 Address Calle campo 12 pabellon docente del hospital clinico universitario virgen de la arrixaca 3 planta el palma 30120 Murcia See on map Region Sur Región de Murcia Murcia Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 LUXEMBOURG INSTITUTE OF HEALTH Luxembourg Net EU contribution € 149 500,00 Address 1a rue rue thomas edison 1445 Strassen See on map Region Luxembourg Luxembourg Luxembourg Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CLUSTERUL REGIONAL INOVATIV DE IMAGISTICA MOLECULARA SI STRUCTURALA NORD-EST (IMAGO-MOL) Romania Net EU contribution € 75 625,00 Address 16 universitatii st building a1 ground floor 700115 Iasi See on map Region Macroregiunea Doi Nord-Est Iaşi Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. ROMSOFT SRL Romania Net EU contribution € 44 750,00 Address Bulevardul chimiei 2 bis cladire c6 etaj 3 700391 Iasi See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Macroregiunea Doi Nord-Est Iaşi Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. CENTRUL DE ONCOLOGIE-EUROCLINIC SRL Romania Net EU contribution € 86 125,00 Address Strada vasile conta 2 700106 Iasi See on map Region Macroregiunea Doi Nord-Est Iaşi Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. UNIVERSITATEA TEHNICA GHEORGHE ASACHI DIN IASI Romania Net EU contribution € 48 125,00 Address B dul dimitru mangeron 67 700050 Iasi See on map Region Macroregiunea Doi Nord-Est Iaşi Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. "SPITATUL CLINIC JUDETEAN DE URGENTA ""SF. SPIRIDON"" IASI" Romania Net EU contribution € 44 375,00 Address B-dul independentei 1 700111 Iasi See on map Region Macroregiunea Doi Nord-Est Iaşi Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 OLOMEDIA SRL Italy Net EU contribution € 248 687,50 Address Via simone cuccia 46 90144 Palermo See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Isole Sicilia Palermo Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Italy Net EU contribution € 576 562,50 Address Via cracovia 50 00133 Roma See on map Region Centro (IT) Lazio Roma Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. UNIVERSITA DEGLI STUDI DI FIRENZE Italy Net EU contribution € 293 750,00 Address Piazza san marco 4 50121 Florence See on map Region Centro (IT) Toscana Firenze Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. AZIENDA OSPEDALIERA UNIVERSITARIA POLICLINICO PAOLO GIACCONE DI PALERMO Italy Net EU contribution € 381 250,00 Address Via del vespro 129 90127 Palermo See on map Region Isole Sicilia Palermo Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. ISTITUTO PER LO STUDIO E LA PREVENZIONE E LA RETE ONCOLOGICA Italy Net EU contribution € 140 000,00 Address Via cosimo il vecchio 2 50139 Firenze See on map Region Centro (IT) Toscana Firenze Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. AZIENDA ULSS N3 SERENISSIMA Italy Net EU contribution € 153 750,00 Address Via don tosatto 147 30174 Venezia mestre See on map Region Nord-Est Veneto Venezia Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
