taRgeted thErapy for adVanced colorEctal canceR paTients

Deliverables

A REVERT website will be designed and maintained, providing open-access to appropriate project information, learning experience for visitors including slides, and publications.

"""First study subject"" approvals package"

The approval package will include1 Final version of REVERT study protocol2 Registration number of clinical study in EudraCT registry that will allow posting of study results3 Approvals from ethics committees and national competent authorities for enrolment of first subject in at least one clinical centre4 Incidental findings policyThe PI will notify to the central IRB the actual beginning of the clinical study represented by the first patient enrolled

Dissemination and communication activity report 1

Dissemination and communication activity reports will be released at M12 and yearly, thereafter, for the entire project life.

Report on SOPs for sample collection, processing and storage, including indicators to monitor quality of samples

Standard operation procedures (SOPs) for samples collection, processing and storage may differ in relation to the type of biomarker to investigate. The SOPs will be designed on the basis of both the biochemical characteristics and the expected grade of stability of every biomarker (or biomarker family). The reference criterion for the validation and the optimization of the SOPs will be the grade of conservation of the analyte through the process. Therefore, when requested by fragile biomarkers, SOPs will be delivered in association with appropriate criteria to assess the stability of the analyte.

Production of shared procedures and choice of the QC material(s) for quality monitoring of analytical phases

Suitable quality control materials will be tested for each marker in comparison to the real matrix according to a standardized procedure, that will be matter of a deliverable. A directory of quality control material(s) recommended for every biomarker will be also delivered. A directory of biomarker(s) for which no commercially available/reliable quality control material(s) will be produced.

Dissemination and communication activity report 2

Dissemination and communication activity reports will be released at M12 and yearly thereafter for the entire project life

Dissemination and communication activity report 3

Dissemination and communication activity reports will be released at M12 and yearly thereafter for the entire project life

FAIR Data management Plan (DMP)

A document structured in various chapters (following the EU instructions) dedicated to: Data Summary; FAIR principles; Resources; Data security; Ethical aspects and other national/funder/sectorial/departmental procedures for data management in use.

Publications

Gene-Mutation-Based Algorithm for Prediction of Treatment Response

Author(s): Johnson, Heather; El-Schich, Zahra; Amjad, Ali; Zhang, Xuhui; Simoulis, Athanasios; Gjörloff Wingren, Anette; Jenny, Persson
Published in: Cancers, Issue Vol. 14, nr 8, artikel-id 2045, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14082045

Red-Emitting Polymerizable Guanidinium Dyes as Fluorescent Probes in Molecularly Imprinted Polymers for Glyphosate Detection

Author(s): Martha Kimani; Víctor Pérez-Padilla; Virginia Valderrey; Kornelia Gawlitza; Knut Rurack
Published in: Chemosensors, Issue 10(3), 2022, Page(s) 99, ISSN 2227-9040
Publisher: MDPI
DOI: 10.3390/chemosensors10030099

Bacterial protein MakA causes suppression of tumour cell proliferation via inhibition of PIP5K1α/Akt signalling

Author(s): Toh, Eric; Baryalai, Palwasha; Nadeem, Aftab; Aung, Kyaw Min; Chen, Sa;Persson, Karina;Persson, Jenny L.; Uhlin, Be
Published in: Cell Death and Disease, 2022, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-022-05480-7

Is High Expression of Claudin-7 in Advanced Colorectal Carcinoma Associated with a Poor Survival Rate? A Comparative Statistical and Artificial Intelligence Study.

Author(s): Ianole V, Danciu M, Volovat C, Stefanescu C, Herghelegiu CP, Leon F, Iftene A, Cusmuliuc CG, Toma B, Drug V, Ciobanu Apostol DG
Published in: Cancers, Issue 14(12):2915, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14122915

Potential Utility of Induced Translocation of Engineered Bacteria as a Therapeutic Agent for Mounting a Personalized Neoantigen‐Based Tumor Immune Response

Author(s): Ginés Luengo-Gil; Pablo Conesa-Zamora
Published in: Crossref, Issue 2, 2021, ISSN 2056-6646
Publisher: Wiley-VCH
DOI: 10.1002/gch2.202100051

Immune Response in Vitamin D Deficient Metastatic Colorectal Cancer Patients: A Player That Should Be Considered for Targeted Vitamin D Supplementation

Author(s): Cristina Morelli, Michela Rofei, Silvia Riondino, Daniela Fraboni, Francesco Torino, Augusto Orlandi, Manfredi Tesauro, Giovanna Del Vecchio Blanco, Massimo Federici, Hendrik-Tobias Arkenau, Vincenzo Formica, Mario Roselli
Published in: Cancers (Basel), 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14112594

Global Methylome Scores Correlate with Histological Subtypes of Colorectal Carcinoma and Show Different Associations with Common Clinical and Molecular Features.

Author(s): María Del Carmen Turpin-Sevilla; Fernando Perez-Sanz; José García-Solano; Patricia Sebastian-Leon; Javier Trujillo-Santos; Pablo Carbonell; Eduardo Estrada; Anne Tuomisto; Irene Herruzo; Lochlan Fennell; Lochlan Fennell; Markus J. Mäkinen; Edith Rodriguez-Braun; Vicki L. J. Whitehall; Vicki L. J. Whitehall; Ana Conesa; Pablo Conesa-Zamora
Published in: Volume 13, Issue 2, 2021, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13205165

Towards the Interpretability of Machine Learning Predictions for Medical Applications Targeting Personalised Therapies: A Cancer Case Survey

Author(s): Antonio Jesús Banegas-Luna, Jorge Peña-García, Adrian Iftene, Fiorella Guadagni, Patrizia Ferroni, Noemi Scarpato, Fabio Massimo Zanzotto, Andrés Bueno-Crespo, Horacio Pérez-Sánchez
Published in: International Journal of Molecular Sciences, Issue 22/9, 2021, Page(s) 4394, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22094394

Circulating Tumor Cell Models Mimicking Metastasizing Cells In Vitro: Discrimination of Colorectal Cancer Cells and White Blood Cells Using Digital Holographic Cytometry

Author(s): Marek Feith, Yuecheng Zhang, Jenny L. Persson, Jan Balvan, Zahra El-Schich, Anette Gjörloff Wingren
Published in: Photonics, 2022, ISSN 2304-6732
Publisher: MDPI
DOI: 10.3390/photonics9120955

Clinical Utility of Plasma KRAS, NRAS and BRAF Mutational Analysis with Real Time PCR in Metastatic Colorectal Cancer Patients—The Importance of Tissue/Plasma Discordant Cases

Author(s): Vincenzo Formica, Jessica Lucchetti, Elena Doldo, Silvia Riondino, Cristina Morelli, Renato Argirò, Nicola Renzi, Daniele Nitti, Antonella Nardecchia, Emanuela Dell’Aquila, Patrizia Ferroni, Fiorella Guadagni, Giampiero Palmieri, Augusto Orlandi, Mario Roselli
Published in: Journal of Clinical Medicine, Issue 10/1, 2021, Page(s) 87, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10010087

Use of Personalized Biomarkers in Metastatic Colorectal Cancer and the Impact of AI

Author(s): Volovat SR, Augustin I, Zob D, Boboc D, Amurariti F, Volovat C, Stefanescu C, Stolniceanu SC, Ciocoiu M, Dumitras EA, Danciu M, Ciobanu Apostol DG, Drug V, Al Shurbaji S, Coca LG, Leon F, Iftene A, Herghelegiu PC.
Published in: Cancers, Issue 14(19):4834, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14194834

Digital holographic microscopy: a noninvasive method to analyze the formation of spheroids

Author(s): El-Schich Zahra
Published in: BioTechniques, 2021, ISSN 0736-6205
Publisher: Eaton Publishing Co.
DOI: 10.2144/btn-2021-0062

Learn Chemistry with Augmented Reality

Author(s): Camelia Macariu, Adrian Iftene, Daniela Gîfu
Published in: Procedia Computer Science, Issue 176, 2020, Page(s) 2133-2142, ISSN 1877-0509
Publisher: Elsevier
DOI: 10.1016/j.procs.2020.09.250

Prehospital Cerebrovascular Accident Detection using Artificial Intelligence Powered Mobile Devices

Author(s): Cristian Simionescu, Madalina Insuratelu, Robert Herscovici
Published in: Procedia Computer Science, Issue 176, 2020, Page(s) 2773-2782, ISSN 1877-0509
Publisher: Elsevier
DOI: 10.1016/j.procs.2020.09.279

Atrial Fibrillation Detection Based on Deep Learning Models

Author(s): Iftene, A., Burlacu, A., Gîfu, D.
Published in: Proceedings of 26th International Conference on Knowledge-Based and Intelligent Information & Engineering Systems. 7-9 September 2022, Verona, Italy, 2022, Page(s) 3752--3760, ISSN 1877-0509
Publisher: Elsevier
DOI: 10.1016/j.procs.2022.09.436

Crack detection system in AWS Cloud using Convolutional neural networks

Author(s): Georgiana-Lucia Coca, Ștefan-Cosmin Romanescu, Șerban-Mihai Botez, Adrian Iftene
Published in: Procedia Computer Science, Issue 176, 2020, Page(s) 400-409, ISSN 1877-0509
Publisher: Elsevier
DOI: 10.1016/j.procs.2020.08.041

Deliverables

Publications

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