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taRgeted thErapy for adVanced colorEctal canceR paTients


REVERT Website

A REVERT website will be designed and maintained, providing open-access to appropriate project information, learning experience for visitors including slides, and publications.

“First study subject” approvals package

The approval package will include 1. Final version of REVERT study protocol. 2. Registration number of clinical study in EudraCT registry that will allow posting of study results. 3. Approvals from ethics committees and national competent authorities for enrolment of first subject in at least one clinical centre. 4. Incidental findings policy. The PI will notify to the central IRB the actual beginning of the clinical study represented by the first patient enrolled.

Dissemination and communication activity report 1

Dissemination and communication activity reports will be released at M12 and yearly, thereafter, for the entire project life.

Report on SOPs for sample collection, processing and storage, including indicators to monitor quality of samples

Standard operation procedures (SOPs) for samples collection, processing and storage may differ in relation to the type of biomarker to investigate. The SOPs will be designed on the basis of both the biochemical characteristics and the expected grade of stability of every biomarker (or biomarker family). The reference criterion for the validation and the optimization of the SOPs will be the grade of conservation of the analyte through the process. Therefore, when requested by fragile biomarkers, SOPs will be delivered in association with appropriate criteria to assess the stability of the analyte.

Production of shared procedures and choice of the QC material(s) for quality monitoring of analytical phases

Suitable quality control materials will be tested for each marker in comparison to the real matrix according to a standardized procedure, that will be matter of a deliverable. A directory of quality control material(s) recommended for every biomarker will be also delivered. A directory of biomarker(s) for which no commercially available/reliable quality control material(s) will be produced.

FAIR Data management Plan (DMP)

A document structured in various chapters (following the EU instructions) dedicated to: Data Summary; FAIR principles; Resources; Data security; Ethical aspects and other national/funder/sectorial/departmental procedures for data management in use.

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Learn Chemistry with Augmented Reality

Author(s): Camelia Macariu, Adrian Iftene, Daniela Gîfu
Published in: Procedia Computer Science, 176, 2020, Page(s) 2133-2142, ISSN 1877-0509
Publisher: Elsevier
DOI: 10.1016/j.procs.2020.09.250

Prehospital Cerebrovascular Accident Detection using Artificial Intelligence Powered Mobile Devices

Author(s): Cristian Simionescu, Madalina Insuratelu, Robert Herscovici
Published in: Procedia Computer Science, 176, 2020, Page(s) 2773-2782, ISSN 1877-0509
Publisher: Elsevier
DOI: 10.1016/j.procs.2020.09.279

Crack detection system in AWS Cloud using Convolutional neural networks

Author(s): Georgiana-Lucia Coca, Ștefan-Cosmin Romanescu, Șerban-Mihai Botez, Adrian Iftene
Published in: Procedia Computer Science, 176, 2020, Page(s) 400-409, ISSN 1877-0509
Publisher: Elsevier
DOI: 10.1016/j.procs.2020.08.041

Towards the Interpretability of Machine Learning Predictions for Medical Applications Targeting Personalised Therapies: A Cancer Case Survey

Author(s): Antonio Jesús Banegas-Luna, Jorge Peña-García, Adrian Iftene, Fiorella Guadagni, Patrizia Ferroni, Noemi Scarpato, Fabio Massimo Zanzotto, Andrés Bueno-Crespo, Horacio Pérez-Sánchez
Published in: International Journal of Molecular Sciences, 22/9, 2021, Page(s) 4394, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22094394

Clinical Utility of Plasma KRAS, NRAS and BRAF Mutational Analysis with Real Time PCR in Metastatic Colorectal Cancer Patients—The Importance of Tissue/Plasma Discordant Cases

Author(s): Vincenzo Formica, Jessica Lucchetti, Elena Doldo, Silvia Riondino, Cristina Morelli, Renato Argirò, Nicola Renzi, Daniele Nitti, Antonella Nardecchia, Emanuela Dell’Aquila, Patrizia Ferroni, Fiorella Guadagni, Giampiero Palmieri, Augusto Orlandi, Mario Roselli
Published in: Journal of Clinical Medicine, 10/1, 2021, Page(s) 87, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10010087