taRgeted thErapy for adVanced colorEctal canceR paTients

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A REVERT website will be designed and maintained, providing open-access to appropriate project information, learning experience for visitors including slides, and publications.

"""First study subject"" approvals package"

The approval package will include1 Final version of REVERT study protocol2 Registration number of clinical study in EudraCT registry that will allow posting of study results3 Approvals from ethics committees and national competent authorities for enrolment of first subject in at least one clinical centre4 Incidental findings policyThe PI will notify to the central IRB the actual beginning of the clinical study represented by the first patient enrolled

Dissemination and communication activity report 1

Dissemination and communication activity reports will be released at M12 and yearly, thereafter, for the entire project life.

Report on SOPs for sample collection, processing and storage, including indicators to monitor quality of samples

Standard operation procedures (SOPs) for samples collection, processing and storage may differ in relation to the type of biomarker to investigate. The SOPs will be designed on the basis of both the biochemical characteristics and the expected grade of stability of every biomarker (or biomarker family). The reference criterion for the validation and the optimization of the SOPs will be the grade of conservation of the analyte through the process. Therefore, when requested by fragile biomarkers, SOPs will be delivered in association with appropriate criteria to assess the stability of the analyte.

Production of shared procedures and choice of the QC material(s) for quality monitoring of analytical phases

Suitable quality control materials will be tested for each marker in comparison to the real matrix according to a standardized procedure, that will be matter of a deliverable. A directory of quality control material(s) recommended for every biomarker will be also delivered. A directory of biomarker(s) for which no commercially available/reliable quality control material(s) will be produced.

Dissemination and communication activity report 2

Dissemination and communication activity reports will be released at M12 and yearly thereafter for the entire project life

Dissemination and communication activity report 3

Dissemination and communication activity reports will be released at M12 and yearly thereafter for the entire project life

FAIR Data management Plan (DMP)

A document structured in various chapters (following the EU instructions) dedicated to: Data Summary; FAIR principles; Resources; Data security; Ethical aspects and other national/funder/sectorial/departmental procedures for data management in use.

Publications

Gene-Mutation-Based Algorithm for Prediction of Treatment Response

Auteurs: Johnson, Heather; El-Schich, Zahra; Amjad, Ali; Zhang, Xuhui; Simoulis, Athanasios; Gjörloff Wingren, Anette; Jenny, Persson
Publié dans: Cancers, Numéro Vol. 14, nr 8, artikel-id 2045, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14082045

Red-Emitting Polymerizable Guanidinium Dyes as Fluorescent Probes in Molecularly Imprinted Polymers for Glyphosate Detection

Auteurs: Martha Kimani; Víctor Pérez-Padilla; Virginia Valderrey; Kornelia Gawlitza; Knut Rurack
Publié dans: Chemosensors, Numéro 10(3), 2022, Page(s) 99, ISSN 2227-9040
Éditeur: MDPI
DOI: 10.3390/chemosensors10030099

Bacterial protein MakA causes suppression of tumour cell proliferation via inhibition of PIP5K1α/Akt signalling

Auteurs: Toh, Eric; Baryalai, Palwasha; Nadeem, Aftab; Aung, Kyaw Min; Chen, Sa;Persson, Karina;Persson, Jenny L.; Uhlin, Be
Publié dans: Cell Death and Disease, 2022, ISSN 2041-4889
Éditeur: Nature Publishing Group
DOI: 10.1038/s41419-022-05480-7

Is High Expression of Claudin-7 in Advanced Colorectal Carcinoma Associated with a Poor Survival Rate? A Comparative Statistical and Artificial Intelligence Study.

Auteurs: Ianole V, Danciu M, Volovat C, Stefanescu C, Herghelegiu CP, Leon F, Iftene A, Cusmuliuc CG, Toma B, Drug V, Ciobanu Apostol DG
Publié dans: Cancers, Numéro 14(12):2915, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14122915

Potential Utility of Induced Translocation of Engineered Bacteria as a Therapeutic Agent for Mounting a Personalized Neoantigen‐Based Tumor Immune Response

Auteurs: Ginés Luengo-Gil; Pablo Conesa-Zamora
Publié dans: Crossref, Numéro 2, 2021, ISSN 2056-6646
Éditeur: Wiley-VCH
DOI: 10.1002/gch2.202100051

Immune Response in Vitamin D Deficient Metastatic Colorectal Cancer Patients: A Player That Should Be Considered for Targeted Vitamin D Supplementation

Auteurs: Cristina Morelli, Michela Rofei, Silvia Riondino, Daniela Fraboni, Francesco Torino, Augusto Orlandi, Manfredi Tesauro, Giovanna Del Vecchio Blanco, Massimo Federici, Hendrik-Tobias Arkenau, Vincenzo Formica, Mario Roselli
Publié dans: Cancers (Basel), 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14112594

Global Methylome Scores Correlate with Histological Subtypes of Colorectal Carcinoma and Show Different Associations with Common Clinical and Molecular Features.

Auteurs: María Del Carmen Turpin-Sevilla; Fernando Perez-Sanz; José García-Solano; Patricia Sebastian-Leon; Javier Trujillo-Santos; Pablo Carbonell; Eduardo Estrada; Anne Tuomisto; Irene Herruzo; Lochlan Fennell; Lochlan Fennell; Markus J. Mäkinen; Edith Rodriguez-Braun; Vicki L. J. Whitehall; Vicki L. J. Whitehall; Ana Conesa; Pablo Conesa-Zamora
Publié dans: Volume 13, Numéro 2, 2021, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13205165

Towards the Interpretability of Machine Learning Predictions for Medical Applications Targeting Personalised Therapies: A Cancer Case Survey

Auteurs: Antonio Jesús Banegas-Luna, Jorge Peña-García, Adrian Iftene, Fiorella Guadagni, Patrizia Ferroni, Noemi Scarpato, Fabio Massimo Zanzotto, Andrés Bueno-Crespo, Horacio Pérez-Sánchez
Publié dans: International Journal of Molecular Sciences, Numéro 22/9, 2021, Page(s) 4394, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22094394

Circulating Tumor Cell Models Mimicking Metastasizing Cells In Vitro: Discrimination of Colorectal Cancer Cells and White Blood Cells Using Digital Holographic Cytometry

Auteurs: Marek Feith, Yuecheng Zhang, Jenny L. Persson, Jan Balvan, Zahra El-Schich, Anette Gjörloff Wingren
Publié dans: Photonics, 2022, ISSN 2304-6732
Éditeur: MDPI
DOI: 10.3390/photonics9120955

Clinical Utility of Plasma KRAS, NRAS and BRAF Mutational Analysis with Real Time PCR in Metastatic Colorectal Cancer Patients—The Importance of Tissue/Plasma Discordant Cases

Auteurs: Vincenzo Formica, Jessica Lucchetti, Elena Doldo, Silvia Riondino, Cristina Morelli, Renato Argirò, Nicola Renzi, Daniele Nitti, Antonella Nardecchia, Emanuela Dell’Aquila, Patrizia Ferroni, Fiorella Guadagni, Giampiero Palmieri, Augusto Orlandi, Mario Roselli
Publié dans: Journal of Clinical Medicine, Numéro 10/1, 2021, Page(s) 87, ISSN 2077-0383
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10010087

Use of Personalized Biomarkers in Metastatic Colorectal Cancer and the Impact of AI

Auteurs: Volovat SR, Augustin I, Zob D, Boboc D, Amurariti F, Volovat C, Stefanescu C, Stolniceanu SC, Ciocoiu M, Dumitras EA, Danciu M, Ciobanu Apostol DG, Drug V, Al Shurbaji S, Coca LG, Leon F, Iftene A, Herghelegiu PC.
Publié dans: Cancers, Numéro 14(19):4834, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14194834

Digital holographic microscopy: a noninvasive method to analyze the formation of spheroids

Auteurs: El-Schich Zahra
Publié dans: BioTechniques, 2021, ISSN 0736-6205
Éditeur: Eaton Publishing Co.
DOI: 10.2144/btn-2021-0062

Learn Chemistry with Augmented Reality

Auteurs: Camelia Macariu, Adrian Iftene, Daniela Gîfu
Publié dans: Procedia Computer Science, Numéro 176, 2020, Page(s) 2133-2142, ISSN 1877-0509
Éditeur: Elsevier
DOI: 10.1016/j.procs.2020.09.250

Prehospital Cerebrovascular Accident Detection using Artificial Intelligence Powered Mobile Devices

Auteurs: Cristian Simionescu, Madalina Insuratelu, Robert Herscovici
Publié dans: Procedia Computer Science, Numéro 176, 2020, Page(s) 2773-2782, ISSN 1877-0509
Éditeur: Elsevier
DOI: 10.1016/j.procs.2020.09.279

Atrial Fibrillation Detection Based on Deep Learning Models

Auteurs: Iftene, A., Burlacu, A., Gîfu, D.
Publié dans: Proceedings of 26th International Conference on Knowledge-Based and Intelligent Information & Engineering Systems. 7-9 September 2022, Verona, Italy, 2022, Page(s) 3752--3760, ISSN 1877-0509
Éditeur: Elsevier
DOI: 10.1016/j.procs.2022.09.436

Crack detection system in AWS Cloud using Convolutional neural networks

Auteurs: Georgiana-Lucia Coca, Ștefan-Cosmin Romanescu, Șerban-Mihai Botez, Adrian Iftene
Publié dans: Procedia Computer Science, Numéro 176, 2020, Page(s) 400-409, ISSN 1877-0509
Éditeur: Elsevier
DOI: 10.1016/j.procs.2020.08.041

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