A high-dimensional approach for unwinding immune-metabolic causes of cardiovascular disease-depression multimorbidities

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Identification of multiplex disease network and markers linked to multimorbidity and disease outcomes.
Enrichment of reference and bespoke datasets on inflammatory markers and construction of gene networks to support causal inference.
Dissemination plan
Molecular QTL analyses in relevant healthy and diseased cells and tissues (M30). Written report
Identification of driver nodes in disease networks
Tissue pleiotropic effects of depression and cardiovascular disease

Web presence and visual identity

Publicaciones

Characteristics of peripheral blood cells are independently related to major adverse cardiovascular events after carotid endarterectomy

Autores: L. Malin Overmars, Joost M. Mekke, Wouter W. van Solinge, Saskia C.A. De Jager, Cornelia A.R. Hulsbergen-Veelken, Imo E. Hoefer, Dominique P.V. de Kleijn, Gert J. de Borst, Sander W. van der Laan, Saskia Haitjema
Publicado en: Atherosclerosis Plus, Edición 52, 2023, Página(s) 32-40, ISSN 2667-0895
Editor: Elsevier B.V.
DOI: 10.1016/j.athplu.2023.05.003

Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression

Autores: Yuri Milaneschi; Matthias Arnold; Gabi Kastenmüller; Siamak Mahmoudian Dehkordi; Ranga R. Krishnan; Boadie W. Dunlop; A. John Rush; Brenda W.J.H. Penninx; Rima Kaddurah-Daouk
Publicado en: Journal of Affective Disorders, Edición 18, 2022, ISSN 0165-0327
Editor: Elsevier BV
DOI: 10.1016/j.jad.2022.03.070

The Applications of Single-Cell RNA Sequencing in Atherosclerotic Disease

Autores: Lotte Slenders; Daniëlle E. Tessels; Sander W. van der Laan; Gerard Pasterkamp; Michal Mokry; Michal Mokry
Publicado en: Frontiers in Cardiovascular Medicine, Vol 9 (2022), Edición 21, 2022, ISSN 2297-055X
Editor: Frontiers
DOI: 10.3389/fcvm.2022.826103

A network analysis of depressive symptoms and metabolomics

Autores: Arja O. Rydin, Yuri Milaneschi, Rick Quax, Jie Li, Jos A. Bosch, Robert A. Schoevers, Erik J. Giltay, Brenda W. J. H. Penninx, Femke Lamers
Publicado en: Psychological Medicine, Edición 53, 2024, Página(s) 7385-7394, ISSN 0033-2917
Editor: Cambridge University Press
DOI: 10.1017/s0033291723001009

Plasma Lipoprotein Lipase Is Associated with Risk of Future Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy

Autores: Joost M. Mekke, Maarten C. Verwer, Erik S.G. Stroes, Jeffrey Kroon, Leo Timmers, Gerard Pasterkamp, Gert J. de Borst, Sander W. van der Laan, Dominique P.V. de Kleijn
Publicado en: European Journal of Vascular and Endovascular Surgery, Edición 65, 2023, Página(s) 700-709, ISSN 1078-5884
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ejvs.2023.01.035

Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels

Autores: Yuekai Ji, Gerard Temprano-Sagrera, Lori A. Holle, Allison Bebo, Jennifer A. Brody, Ngoc-Quynh Le, Kadri Kangro, Michael R. Brown, Angel Martinez-Perez, Colleen M. Sitlani, Pierre Suchon, Marcus E. Kleber, David B. Emmert, Ayse Bilge Ozel, Dre’Von A. Dobson, Weihong Tang, Dolors Llobet, Russell P. Tracy, Jean-François Deleuze, Graciela E. Delgado, Martin Gögele, Kerri L. Wiggins, Juan Carlos S
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, Edición 43, 2024, ISSN 1079-5642
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.122.318213

Trajectories of depressive symptoms, metabolic syndrome, inflammation, and cardiometabolic diseases: A longitudinal Bayesian network approach

Autores: Arja O. Rydin, Yuri Milaneschi, Femke Lamers, Rick Quax, Noah van de Bunt, Angela Koloi, Bennard Doornbos, Brenda W.J.H. Penninx
Publicado en: Brain, Behavior, and Immunity, Edición 130, 2025, Página(s) 106120, ISSN 0889-1591
Editor: Academic Press
DOI: 10.1016/j.bbi.2025.106120

Gut microbiome-wide association study of depressive symptoms

Autores: Djawad Radjabzadeh; Jos A. Bosch; André G. Uitterlinden; Aeilko H. Zwinderman; M. Arfan Ikram; Joyce B. J. van Meurs; Annemarie I. Luik; Max Nieuwdorp; Anja Lok; Cornelia M. van Duijn; Robert Kraaij; Najaf Amin
Publicado en: Nature Communications, Edición 18, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-34502-3

Immunometabolic Pathways: Investigating Mediators of Major Depressive Disorder and Atherosclerotic Cardiovascular Disease Comorbidity

Autores: Angela Koloi, Nabila P.R. Siregar, Rick Quax, Antonis I. Sakellarios, Femke Lamers, Arja Rydin, Kevin Dobretz, Costas Papaloukas, Dimitrios I. Fotiadis, Jos A. Bosch
Publicado en: Biological Psychiatry Global Open Science, Edición 5, 2025, Página(s) 100528, ISSN 2667-1743
Editor: Elsevier BV
DOI: 10.1016/j.bpsgos.2025.100528

The Effects of FABP4 on Cardiovascular Disease in the Aging Population

Autores: Ellen M. van der Ark-Vonk, Mike V. Puijk, Gerard Pasterkamp, Sander W. van der Laan
Publicado en: Current Atherosclerosis Reports, Edición 26, 2024, Página(s) 163-175, ISSN 1523-3804
Editor: Current Science Inc.
DOI: 10.1007/s11883-024-01196-5

Gene set analysis of transcriptomics data identifies new biological processes associated with early markers of atherosclerosis but not with those of osteoporosis : Atherosclerosis-osteoporosis co/multimorbidity study in the Young Finns Study

Autores: Binisha H. Mishra; Harri Sievänen; Emma Raitoharju; Nina Mononen; Jorma Viikari; Markus Juonala; Marika Laaksonen; Nina Hutri-Kähönen; Mika Kähönen; Olli T. Raitakari; Terho Lehtimäki; Pashupati P. Mishra
Publicado en: Atherosclerosis, Edición 26, 2022, ISSN 0021-9150
Editor: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2022.10.005

Proteomic profiling reveals a higher presence of glycolytic enzymes in human atherosclerotic lesions with unfavourable histological characteristics

Autores: Kaylin C A Palm, Xiaoke Yin, Ferheen Baig, Konstantinos Theofilatos, Sander W van der Laan, Gert J de Borst, Dominique P V de Kleijn, Johann Wojta, Stefan Stojkovic, Manuel Mayr, Hester M den Ruijter, Gerard Pasterkamp, Ernest Diez Benavente, Michal Mokry
Publicado en: Cardiovascular Research, Edición 121, 2025, Página(s) 1187-1203, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvaf077

Anxiety and mood disorders on the rise: exploring clinical profiles and risk factors

Autores: Artemis Gkitakou, Margreet Ten Have, Neeltje M. Batelaan, Annemarie I. Luik, Brenda W. J. H. Penninx
Publicado en: The British Journal of Psychiatry, 2025, Página(s) 1-8, ISSN 0007-1250
Editor: Royal College of Psychiatrists
DOI: 10.1192/bjp.2025.10454

Circulating Brain-Related miRNAs as Predictors of Postoperative Delirium in Cardiac Surgery Patients

Autores: Karina Nowakowska, Grzegorz Walkiewicz, Emilia Stec-Martyna, Dominika Kulczycka-Wojdala, Emilia Frankowska, Piotr Miler, Agnieszka Pawlak, Katarzyna Woźniak, Michał Krejca, Mirosław Wilczyński, Jakub Kazmierski
Publicado en: International Journal of Molecular Sciences, Edición 26, 2025, Página(s) 9062, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26189062

Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis

Autores: Lotte Slenders, Lennart P L Landsmeer, Kai Cui, Marie A C Depuydt, Maarten Verwer, Joost Mekke, Nathalie Timmerman, Noortje A M van den Dungen, Johan Kuiper, Menno P J de Winther, Koen H M Prange, Wei Feng Ma, Clint L Miller, Redouane Aherrahrou, Mete Civelek, Gert J de Borst, Dominique P V de Kleijn, Folkert W Asselbergs, Hester M den Ruijter, Arjan Boltjes, Gerard Pasterkamp, Sander W van der La
Publicado en: European Heart Journal Open, Edición 2, 2023, ISSN 2752-4191
Editor: Oxford University Press (OUP)
DOI: 10.1093/ehjopen/oeab043

Bias in O-Information Estimation

Autores: Johanna Gehlen, Jie Li, Cillian Hourican, Stavroula Tassi, Pashupati P. Mishra, Terho Lehtimäki, Mika Kähönen, Olli Raitakari, Jos A. Bosch, Rick Quax
Publicado en: Entropy, Edición 26, 2025, Página(s) 837, ISSN 1099-4300
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/e26100837

Assessment of plasma ceramides as predictor for subclinical atherosclerosis

Autores: Pashupati P. Mishra; Binisha H. Mishra; Leo-Pekka Lyytikäinen; Mika Hilvo; Markus Juonala; Markus Juonala; Mika Kähönen; Nina Hutri-Kähönen; Dimitrios I. Fotiadis; Dimitrios I. Fotiadis; Olli T. Raitakari; Olli T. Raitakari; Reijo Laaksonen; Terho Lehtimäki
Publicado en: Atherosclerosis Plus, Edición 1, 2021, ISSN 2667-0895
Editor: Elsevier BV
DOI: 10.1016/j.athplu.2021.09.005

Predicting early-stage coronary artery disease using machine learning and routine clinical biomarkers improved by augmented virtual data

Autores: Angela Koloi, Vasileios S Loukas, Cillian Hourican, Antonis I Sakellarios, Rick Quax, Pashupati P Mishra, Terho Lehtimäki, Olli T Raitakari, Costas Papaloukas, Jos A Bosch, Winfried März, Dimitrios I Fotiadis
Publicado en: European Heart Journal - Digital Health, Edición 5, 2024, Página(s) 542-550, ISSN 2634-3916
Editor: Oxford University Press (OUP)
DOI: 10.1093/ehjdh/ztae049

Regulation of nc886 (vtRNA2-1) RNAs is associated with cardiometabolic risk factors and diseases

Autores: Sonja Rajić, Thomas Delerue, Justiina Ronkainen, Ruiyuan Zhang, Joanna Ciantar, Daria Kostiniuk, Pashupati P. Mishra, Leo-Pekka Lyytikäinen, Nina Mononen, Laura Kananen, Annette Peters, Juliane Winkelmann, Marcus E. Kleber, Stefan Lorkowski, Mika Kähönen, Terho Lehtimäki, Olli Raitakari, Melanie Waldenberger, Christian Gieger, Winfried März, Emily W. Harville, Sylvain Sebert, Saara Marttila,
Publicado en: Clinical Epigenetics, Edición 17, 2025, ISSN 1868-7083
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s13148-025-01871-7

Genetic risk score for coronary artery calcification and its predictive ability for coronary artery disease

Autores: Pashupati P. Mishra, Binisha H. Mishra, Leo-Pekka Lyytikäinen, Sirkka Goebeler, Mika Martiskainen, Emma Hakamaa, Marcus E. Kleber, Graciela E. Delgado, Winfried März, Mika Kähönen, Pekka J. Karhunen, Terho Lehtimäki
Publicado en: American Journal of Preventive Cardiology, Edición 20, 2025, Página(s) 100884, ISSN 2666-6677
Editor: Elsevier BV
DOI: 10.1016/j.ajpc.2024.100884

Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis

Autores: Chad S. Weldy, Qin Li, João P. Monteiro, Tim S. Peters, Hongchao Guo, Drew Galls, Wenduo Gu, Paul P. Cheng, Markus Ramste, Daniel Li, Brian T. Palmisano, Disha Sharma, Matthew D. Worssam, Quanyi Zhao, Amruta Bhate, Ramendra K. Kundu, Trieu Nguyen, Michal Mokry, Clint L. Miller, Sander W. van der Laan, Jin Billy Li, Thomas Quertermous
Publicado en: Nature Cardiovascular Research, Edición 4, 2025, Página(s) 1241-1257, ISSN 2731-0590
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44161-025-00710-5

Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci

Autores: Chani J. Hodonsky, Adam W. Turner, Mohammad Daud Khan, Nelson B. Barrientos, Ruben Methorst, Lijiang Ma, Nicolas G. Lopez, Jose Verdezoto Mosquera, Gaëlle Auguste, Emily Farber, Wei Feng Ma, Doris Wong, Suna Onengut-Gumuscu, Maryam Kavousi, Patricia A. Peyser, Sander W. van der Laan, Nicholas J. Leeper, Jason C. Kovacic, Johan L.M. Björkegren, Clint L. Miller
Publicado en: Cell Genomics, Edición 4, 2024, Página(s) 100465, ISSN 2666-979X
Editor: Cell Press
DOI: 10.1016/j.xgen.2023.100465

Comparing Inflammatory Biomarkers in Cardiovascular Disease: Insights from the LURIC Study

Autores: Angela P. Moissl, Graciela E. Delgado, Hubert Scharnagl, Rüdiger Siekmeier, Bernhard K. Krämer, Daniel Duerschmied, Winfried März, Marcus E. Kleber
Publicado en: International Journal of Molecular Sciences, Edición 26, 2025, Página(s) 7335, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26157335

Morbidity-bridging metabolic pathways: linking early cardiovascular disease risk and depression symptoms using a multi-modal approach

Autores: Angela Koloi, Arja Rydin, Yuri Milaneschi, Femke Lamers, Jos A Bosch, Emma Pruin, Sander W van der Laan, Pashupati P Mishra, Terho Lehtimäki, Mika Kähönen, Olli T Raitakari, Dimitrios I Fotiadis, Rick Quax
Publicado en: European Heart Journal Open, Edición 5, 2025, ISSN 2752-4191
Editor: Oxford University Press (OUP)
DOI: 10.1093/ehjopen/oeaf038

Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

Autores: Tanmoy Roychowdhury, Derek Klarin, Michael G. Levin, Joshua M. Spin, Yae Hyun Rhee, Alicia Deng, Colwyn A. Headley, Noah L. Tsao, Corry Gellatly, Verena Zuber, Fred Shen, Whitney E. Hornsby, Ina Holst Laursen, Shefali S. Verma, Adam E. Locke, Gudmundur Einarsson, Gudmar Thorleifsson, Sarah E. Graham, Ozan Dikilitas, Jack W. Pattee, Renae L. Judy, Ferran Pauls-Verges, Jonas B. Nielsen, Brooke N. Wo
Publicado en: Nature Genetics, Edición 55, 2023, Página(s) 1831-1842, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-023-01510-y

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis

Autores: Jose Verdezoto Mosquera, Gaëlle Auguste, Doris Wong, Adam W. Turner, Chani J. Hodonsky, Astrid Catalina Alvarez-Yela, Yipei Song, Qi Cheng, Christian L. Lino Cardenas, Konstantinos Theofilatos, Maxime Bos, Maryam Kavousi, Patricia A. Peyser, Manuel Mayr, Jason C. Kovacic, Johan L.M. Björkegren, Rajeev Malhotra, P. Todd Stukenberg, Aloke V. Finn, Sander W. van der Laan, Chongzhi Zang, Nathan C. S
Publicado en: Cell Reports, Edición 42, 2024, Página(s) 113380, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.113380

The accumulation of erythrocytes quantified and visualized by Glycophorin C in carotid atherosclerotic plaque reflects intraplaque hemorrhage and pre-procedural neurological symptoms

Autores: Joost M. Mekke, Tim R. Sakkers, Maarten C. Verwer, Noortje A. M. van den Dungen, Yipei Song, Clint L. Miller, Aloke V. Finn, Gerard Pasterkamp, Michal Mokry, Hester M. den Ruijter, Aryan Vink, Dominique P. V. de Kleijn, Gert J. de Borst, Saskia Haitjema, Sander W. van der Laan
Publicado en: Scientific Reports, Edición 13, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-43369-3

The gut microbiota and depressive symptoms across ethnic groups

Autores: Jos A. Bosch; Max Nieuwdorp; Aeilko H. Zwinderman; Mélanie Deschasaux; Djawad Radjabzadeh; Robert Kraaij; Mark Davids; Susanne R. de Rooij; Anja Lok
Publicado en: Nature Communications, Edición 19, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-34504-1

Major depression and atherosclerotic disease: Linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques

Autores: Emma Pruin, Meike Bartels, Ernest Diez Benavente, Noortje A.M. van den Dungen, Joost K.R. Hoekstra, Dominique D.P. de Kleijn, Lennart P.L. Landsmeer, Michal Mokry, Gerard Pasterkamp, Brenda W.J.H. Penninx, Wouter J. Peyrot, Hester M. den Ruijter, Sander W. van der Laan, Yuri Milaneschi
Publicado en: European Neuropsychopharmacology, Edición 106, 2026, Página(s) 112780, ISSN 0924-977X
Editor: Elsevier BV
DOI: 10.1016/j.euroneuro.2026.112780

Efficient Search Algorithms for Identifying Synergistic Associations in High-Dimensional Datasets

Autores: Cillian Hourican, Jie Li, Pashupati P. Mishra, Terho Lehtimäki, Binisha H. Mishra, Mika Kähönen, Olli T. Raitakari, Reijo Laaksonen, Liisa Keltikangas-Järvinen, Markus Juonala, Rick Quax
Publicado en: Entropy, Edición 26, 2025, Página(s) 968, ISSN 1099-4300
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/e26110968

BioTextQuest v2.0: An evolved tool for biomedical literature mining and concept discovery

Autores: Theodosios Theodosiou, Konstantinos Vrettos, Ismini Baltsavia, Fotis Baltoumas, Nikolas Papanikolaou, Andreas Ν. Antonakis, Dimitrios Mossialos, Christos A. Ouzounis, Vasilis J. Promponas, Makrina Karaglani, Ekaterini Chatzaki, Sven Brandau, Georgios A. Pavlopoulos, Evangelos Andreakos, Ioannis Iliopoulos
Publicado en: Computational and Structural Biotechnology Journal, Edición 23, 2026, Página(s) 3247-3253, ISSN 2001-0370
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1016/j.csbj.2024.08.016

Notch signaling in adipose tissue macrophages prevents diet‐induced inflammation and metabolic dysregulation

Autores: Eleni Siouti, Maria Salagianni, Maria Manioudaki, Eleftherios Pavlos, Apostolos Klinakis, Ioanna‐Evdokia Galani, Evangelos Andreakos
Publicado en: European Journal of Immunology, Edición 54, 2024, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202350669

Effect of tissue-grouped regulatory variants associated to type 2 diabetes in related secondary outcomes

Autores: Daiane Hemerich, Roelof A. J. Smit, Michael Preuss, Lauren Stalbow, Sander W. van der Laan, Folkert W. Asselbergs, Jessica van Setten, Vinicius Tragante
Publicado en: Scientific Reports, Edición 13, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-30369-6

Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values

Autores: Gabin Drouard; Miina Ollikainen; Juha Mykkänen; Olli Raitakari; Terho Lehtimäki; Mika Kähönen; Pashupati P. Mishra; Xiaoling Wang; Jaakko Kaprio
Publicado en: OMICS: A journal of integrative biology, Edición 28, 2022, ISSN 1536-2310
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/omi.2021.0201

PolarMorphism enables discovery of shared genetic variants across multiple traits from GWAS summary statistics.

Autores: Joanna von Berg; Michelle ten Dam; Sander W van der Laan; Jeroen de Ridder
Publicado en: Bioinformatics, Edición 23, 2022, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1101/2022.01.14.476302

Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis

Autores: Janne Pott, Azin Kheirkhah, Jesper R. Gadin, Marcus E. Kleber, Graciela E. Delgado, Holger Kirsten, Lukas Forer, Stefanie M. Hauck, Ralph Burkhardt, Hubert Scharnagl, Markus Loeffler, Winfried März, Joachim Thiery, Christian Gieger, Annette Peters, Angela Silveira, Ferdinand van’t Hooft, Florian Kronenberg, Markus Scholz
Publicado en: Biology of Sex Differences, Edición 15, 2024, ISSN 2042-6410
Editor: BMC
DOI: 10.1186/s13293-024-00602-6

Genetically determined ancestry associates with morphological and molecular carotid plaque features

Autores: Nima Fahim, Tim R. Sakkers, Floor B.H. van der Zalm, Joost Hoekstra, Dominique P.V. de Kleijn, Michal Mokry, Jose Verdezoto Mosquera, Gerard Pasterkamp, Hester M. den Ruijter, Clint L. Miller, Jessica van Setten, Sander W. van der Laan
Publicado en: Atherosclerosis, Edición 415, 2026, Página(s) 120680, ISSN 0021-9150
Editor: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2026.120680

Metabolomics signatures of depression: the role of symptom profiles

Autores: Hilde de Kluiver, Rick Jansen, Brenda W. J. H. Penninx, Erik J. Giltay, Robert A. Schoevers, Yuri Milaneschi
Publicado en: Translational Psychiatry, Edición 13, 2023, ISSN 2158-3188
Editor: Nature Publishing Group
DOI: 10.1038/s41398-023-02484-5

Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a <scp>Genome‐Wide</scp> Association <scp>Meta‐Analysis</scp> Followed by Mendelian Randomization

Autores: Jie Zheng, Eleanor Wheeler, Maik Pietzner, Till F. M. Andlauer, Michelle S. Yau, April E. Hartley, Ben Michael Brumpton, Humaira Rasheed, John P. Kemp, Monika Frysz, Jamie Robinson, Sjur Reppe, Vid Prijatelj, Kaare M. Gautvik, Louise Falk, Winfried Maerz, Ingrid Gergei, Patricia A. Peyser, Maryam Kavousi, Paul S. de Vries, Clint L. Miller, Maxime Bos, Sander W. van der Laan, Rajeev Malhotra, Marku
Publicado en: Arthritis & Rheumatology, Edición 75, 2023, Página(s) 1781-1792, ISSN 2326-5191
Editor: Wiley & Sons
DOI: 10.1002/art.42538

Leptin and leptin receptor gene polymorphisms and depression treatment response

Autores: Ida-Maria Tavast, Anssi Solismaa, Leo-Pekka Lyytikäinen, Nina Mononen, Eeva Moilanen, Mari Hämäläinen, Terho Lehtimäki, Olli Kampman
Publicado en: Acta Neuropsychiatrica, Edición 37, 2025, ISSN 0924-2708
Editor: Blackwell Publishing Inc.
DOI: 10.1017/neu.2024.43

How location and cellular signaling combine to activate the NLRP3 inflammasome

Autores: Anil Akbal; Alesja Dernst; Marta Lovotti; Matthew S. J. Mangan; Róisín M. McManus; Eicke Latz
Publicado en: Cellular and molecular immunology, Edición 19, 2022, ISSN 1672-7681
Editor: Nature Publishing Group
DOI: 10.1038/s41423-022-00922-w

AI-Enhanced Predictive Modeling for Identifying Depression and Delirium in Cardiovascular Patients Scheduled for Cardiac Surgery

Autores: Karina Nowakowska, Antonis Sakellarios, Jakub Kaźmierski, Dimitrios I. Fotiadis, Vasileios C. Pezoulas
Publicado en: Diagnostics, Edición 14, 2023, Página(s) 67, ISSN 2075-4418
Editor: MDPI
DOI: 10.3390/diagnostics14010067

An automatic entropy method to efficiently mask histology whole-slide images

Autores: Yipei Song, Francesco Cisternino, Joost M. Mekke, Gert J. de Borst, Dominique P. V. de Kleijn, Gerard Pasterkamp, Aryan Vink, Craig A. Glastonbury, Sander W. van der Laan, Clint L. Miller
Publicado en: Scientific Reports, Edición 13, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-29638-1

Identification of gene networks jointly associated with depressive symptoms and cardiovascular health metrics using whole blood transcriptome in the Young Finns Study

Autores: Binisha H. Mishra, Emma Raitoharju, Nina Mononen, Aino Saarinen, Jorma Viikari, Markus Juonala, Nina Hutri-Kähönen, Mika Kähönen, Olli T. Raitakari, Terho Lehtimäki, Pashupati P. Mishra
Publicado en: Frontiers in Psychiatry, Edición 15, 2024, ISSN 1664-0640
Editor: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2024.1345159

Predicting incident cardio-metabolic disease among persons with and without depressive and anxiety disorders: a machine learning approach

Autores: Arja O. Rydin, George Aalbers, Wessel A. van Eeden, Femke Lamers, Yuri Milaneschi, Brenda W. J. H. Penninx
Publicado en: Social Psychiatry and Psychiatric Epidemiology, Edición 60, 2025, Página(s) 1457-1466, ISSN 0933-7954
Editor: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00127-025-02857-9

LoFTK: a framework for fully automated calculation of predicted Loss-of-Function variants

Autores: Folkert W. Asselbergs; Folkert W. Asselbergs; Jason H. Moore; Brendan J. Keating; A. Alasiri; A. Alasiri; S.W. Van Der Laan; Brian S. Cole; J. van Setten; Bao-Li Loza; Konrad J. Karczewski; Konrad J. Karczewski
Publicado en: BioData Mining, Edición 15, 2023, ISSN 1756-0381
Editor: BioMed Central
DOI: 10.1101/2021.08.09.455694

Genetic crossroads of cardiovascular disease and its comorbidities: toward holistic therapeutic strategies

Autores: Binisha H. Mishra, Pashupati P. Mishra
Publicado en: BMC Medical Genomics, Edición 19, 2026, ISSN 1755-8794
Editor: BioMed Central
DOI: 10.1186/s12920-025-02279-1

High genetic risk for depression as an independent risk factor for mortality in patients referred for coronary angiography

Autores: Robert M. Krämer, Angela P. Moissl, Stefan Lorkowski, Bernhard K. Krämer, Terho Lehtimäki, Binisha H. Mishra, Pashupati P. Mishra, Jan Leipe, Winfried März, Marcus E. Kleber, Bertram Müller-Myhsok, Graciela E. Delgado
Publicado en: Frontiers in Cardiovascular Medicine, Edición 10, 2023, ISSN 2297-055X
Editor: Frontiers Media SA
DOI: 10.3389/fcvm.2023.1125151

Druggable proteins influencing cardiac structure and function: implications for heart failure therapies and cancer related cardiotoxicity

Autores: Amand Schmidt; Mimount Bourfiss; Abdulrahman Alasiri; Sandesh Chopade; Esther Puyol-Anton; Marion van Vugt; Sander van der Laan; Anneline ter Riele; Birgitta Velthuis; Nora Franceschini; Bram Ruijsink; Aroon Hingorani; Pim van der Harst; Christian Gross; Chris Clarkson; Albert Henry; R Lumbers; Joshua Bis; Folkert Asselbergs; Jessica van Setten; Chris Finan
Publicado en: Science Advances, Edición 30, 2023, ISSN 2375-2548
Editor: AAAS
DOI: 10.21203/rs.3.rs-1305500/v1

A multilayer network analysis of cardiovascular–depression comorbidity reveals symptom-specific molecular biomarkers

Autores: Jie Li, Jos A. Bosch, Arja O. Rydin, Cillian Hourican, Angela Koloi, Stavroula Tassi, Pashupati P. Mishra, Binisha H. Mishra, Mika Kähönen, Terho Lehtimäki, Olli T. Raitakari, Reijo Laaksonen, Liisa Keltikangas-Järvinen, Markus Juonala, Rick Quax
Publicado en: Psychological Medicine, Edición 55, 2025, ISSN 0033-2917
Editor: Cambridge University Press
DOI: 10.1017/s0033291725102109

Platelet Reactivity and Cardiovascular Mortality Risk in the LURIC Study

Autores: Martin Berger, Alexander Dressel, Marcus E. Kleber, Winfried März, Peter Hellstern, Nikolaus Marx, Katharina Schütt
Publicado en: Journal of Clinical Medicine, Edición 12, 2023, Página(s) 1913, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm12051913

Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness

Autores: Devendra Meena, Jian Huang, Marjan Zare, Natalie R. Hasbani, BOUA Palwendé Romuald, Rima Mustafa, Sander W van der Laan, Huichun Xu, James G. Terry, Joshua C. Bis, Deepti Jain, Nicholette D. Palmer, Nancy Heard-Costa, Yuan-I Min, Xiuqing Guo, Jie Yao, Kent D. Taylor, Jingyi Tan, Juan Peralta, Alexandre C. Pereira, Alyna Khan, Ananyo Choudhury, Anne B. Newman, Anny H. Xiang, Aroon Hingorani, Barry
Publicado en: 2026
Editor: openRxiv
DOI: 10.1101/2025.04.11.25325582

The Metabolome-Wide Signature of Major Depressive Disorder

Autores: Rick Jansen, yuri milaneschi, Daniela Schranner, Gabi Kastenmüller, Matthias Arnold, Xianlin Han, Boadie Dunlop, A Rush, Rima Kaddurah-Daouk, Brenda Penninx
Publicado en: Research Square, 2024
Editor: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-3127544/v1

Metabolomic Signatures Linking Depressive Symptoms to Atherosclerotic Cardiovascular Disease Comorbidity: Evidence from the UK Biobank

Autores: Angela Koloi, Kevin Dobretz, Dafne Damman, Rick Quax, Dimitris Zaridis, Costas Papaloukas, Dimitrios Fotiadis, Jos Bosch
Publicado en: Research Square, 2025
Editor: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-6422455/v1

Intraplaque haemorrhage quantification and molecular characterisation using attention based multiple instance learning

Autores: Francesco Cisternino, Yipei Song, Tim S. Peters, Roderick Westerman, Gert J. de Borst, Ernest Diez Benavente, Noortje A.M. van den Dungen, Petra H. van der Kraak, Dominique De Kleijn, Joost M. Mekke, Michal Mokry, Gerard Pasterkamp, Hester M. den Ruijter, Evelyn Velema, Clint L. Miller, Craig A. Glastonbury, Sander W. van der Laan
Publicado en: 2026
Editor: openRxiv
DOI: 10.1101/2025.03.04.25323316

Sphingomyelin d18:1/14:0 activates TLR4 in metaflammation

Autores: Eicke Latz; Friederike Gorki; Lenka Dohnalová; Christoph Thaiss; Jelena Zurkovic; Anette Christ; Umeharu Ohto; Jan Marzinek; Peter J. Bond; Eike Geißmar; Santu Singha; Arslan Hamid; Mohamed Yaghmour; Kyra de Goede; Maximilian Rothe; Katarzyna Placek; Amin Polzin; Philipp Wollnitzke; Bodo Levkau; Michael Fitzgerald; Joost Rutten; Mihai Netea; Niels Riksen; Christoph Thiele; Andreas Pfeiffer; Pete
Publicado en: Research Square, Edición 14, 2023, ISSN 2693-5015
Editor: Research Square
DOI: 10.21203/rs.3.rs-2792338/v1

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