A high-dimensional approach for unwinding immune-metabolic causes of cardiovascular disease-depression multimorbidities

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Identification of multiplex disease network and markers linked to multimorbidity and disease outcomes.
Enrichment of reference and bespoke datasets on inflammatory markers and construction of gene networks to support causal inference.
Dissemination plan
Molecular QTL analyses in relevant healthy and diseased cells and tissues (M30). Written report
Identification of driver nodes in disease networks
Tissue pleiotropic effects of depression and cardiovascular disease

Web presence and visual identity

Publications

Characteristics of peripheral blood cells are independently related to major adverse cardiovascular events after carotid endarterectomy

Auteurs: L. Malin Overmars, Joost M. Mekke, Wouter W. van Solinge, Saskia C.A. De Jager, Cornelia A.R. Hulsbergen-Veelken, Imo E. Hoefer, Dominique P.V. de Kleijn, Gert J. de Borst, Sander W. van der Laan, Saskia Haitjema
Publié dans: Atherosclerosis Plus, Numéro 52, 2023, Page(s) 32-40, ISSN 2667-0895
Éditeur: Elsevier B.V.
DOI: 10.1016/j.athplu.2023.05.003

Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression

Auteurs: Yuri Milaneschi; Matthias Arnold; Gabi Kastenmüller; Siamak Mahmoudian Dehkordi; Ranga R. Krishnan; Boadie W. Dunlop; A. John Rush; Brenda W.J.H. Penninx; Rima Kaddurah-Daouk
Publié dans: Journal of Affective Disorders, Numéro 18, 2022, ISSN 0165-0327
Éditeur: Elsevier BV
DOI: 10.1016/j.jad.2022.03.070

The Applications of Single-Cell RNA Sequencing in Atherosclerotic Disease

Auteurs: Lotte Slenders; Daniëlle E. Tessels; Sander W. van der Laan; Gerard Pasterkamp; Michal Mokry; Michal Mokry
Publié dans: Frontiers in Cardiovascular Medicine, Vol 9 (2022), Numéro 21, 2022, ISSN 2297-055X
Éditeur: Frontiers
DOI: 10.3389/fcvm.2022.826103

A network analysis of depressive symptoms and metabolomics

Auteurs: Arja O. Rydin, Yuri Milaneschi, Rick Quax, Jie Li, Jos A. Bosch, Robert A. Schoevers, Erik J. Giltay, Brenda W. J. H. Penninx, Femke Lamers
Publié dans: Psychological Medicine, Numéro 53, 2024, Page(s) 7385-7394, ISSN 0033-2917
Éditeur: Cambridge University Press
DOI: 10.1017/s0033291723001009

Plasma Lipoprotein Lipase Is Associated with Risk of Future Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy

Auteurs: Joost M. Mekke, Maarten C. Verwer, Erik S.G. Stroes, Jeffrey Kroon, Leo Timmers, Gerard Pasterkamp, Gert J. de Borst, Sander W. van der Laan, Dominique P.V. de Kleijn
Publié dans: European Journal of Vascular and Endovascular Surgery, Numéro 65, 2023, Page(s) 700-709, ISSN 1078-5884
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ejvs.2023.01.035

Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels

Auteurs: Yuekai Ji, Gerard Temprano-Sagrera, Lori A. Holle, Allison Bebo, Jennifer A. Brody, Ngoc-Quynh Le, Kadri Kangro, Michael R. Brown, Angel Martinez-Perez, Colleen M. Sitlani, Pierre Suchon, Marcus E. Kleber, David B. Emmert, Ayse Bilge Ozel, Dre’Von A. Dobson, Weihong Tang, Dolors Llobet, Russell P. Tracy, Jean-François Deleuze, Graciela E. Delgado, Martin Gögele, Kerri L. Wiggins, Juan Carlos S
Publié dans: Arteriosclerosis, Thrombosis, and Vascular Biology, Numéro 43, 2024, ISSN 1079-5642
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.122.318213

Trajectories of depressive symptoms, metabolic syndrome, inflammation, and cardiometabolic diseases: A longitudinal Bayesian network approach

Auteurs: Arja O. Rydin, Yuri Milaneschi, Femke Lamers, Rick Quax, Noah van de Bunt, Angela Koloi, Bennard Doornbos, Brenda W.J.H. Penninx
Publié dans: Brain, Behavior, and Immunity, Numéro 130, 2025, Page(s) 106120, ISSN 0889-1591
Éditeur: Academic Press
DOI: 10.1016/j.bbi.2025.106120

Gut microbiome-wide association study of depressive symptoms

Auteurs: Djawad Radjabzadeh; Jos A. Bosch; André G. Uitterlinden; Aeilko H. Zwinderman; M. Arfan Ikram; Joyce B. J. van Meurs; Annemarie I. Luik; Max Nieuwdorp; Anja Lok; Cornelia M. van Duijn; Robert Kraaij; Najaf Amin
Publié dans: Nature Communications, Numéro 18, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-34502-3

Immunometabolic Pathways: Investigating Mediators of Major Depressive Disorder and Atherosclerotic Cardiovascular Disease Comorbidity

Auteurs: Angela Koloi, Nabila P.R. Siregar, Rick Quax, Antonis I. Sakellarios, Femke Lamers, Arja Rydin, Kevin Dobretz, Costas Papaloukas, Dimitrios I. Fotiadis, Jos A. Bosch
Publié dans: Biological Psychiatry Global Open Science, Numéro 5, 2025, Page(s) 100528, ISSN 2667-1743
Éditeur: Elsevier BV
DOI: 10.1016/j.bpsgos.2025.100528

The Effects of FABP4 on Cardiovascular Disease in the Aging Population

Auteurs: Ellen M. van der Ark-Vonk, Mike V. Puijk, Gerard Pasterkamp, Sander W. van der Laan
Publié dans: Current Atherosclerosis Reports, Numéro 26, 2024, Page(s) 163-175, ISSN 1523-3804
Éditeur: Current Science Inc.
DOI: 10.1007/s11883-024-01196-5

Gene set analysis of transcriptomics data identifies new biological processes associated with early markers of atherosclerosis but not with those of osteoporosis : Atherosclerosis-osteoporosis co/multimorbidity study in the Young Finns Study

Auteurs: Binisha H. Mishra; Harri Sievänen; Emma Raitoharju; Nina Mononen; Jorma Viikari; Markus Juonala; Marika Laaksonen; Nina Hutri-Kähönen; Mika Kähönen; Olli T. Raitakari; Terho Lehtimäki; Pashupati P. Mishra
Publié dans: Atherosclerosis, Numéro 26, 2022, ISSN 0021-9150
Éditeur: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2022.10.005

Proteomic profiling reveals a higher presence of glycolytic enzymes in human atherosclerotic lesions with unfavourable histological characteristics

Auteurs: Kaylin C A Palm, Xiaoke Yin, Ferheen Baig, Konstantinos Theofilatos, Sander W van der Laan, Gert J de Borst, Dominique P V de Kleijn, Johann Wojta, Stefan Stojkovic, Manuel Mayr, Hester M den Ruijter, Gerard Pasterkamp, Ernest Diez Benavente, Michal Mokry
Publié dans: Cardiovascular Research, Numéro 121, 2025, Page(s) 1187-1203, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvaf077

Anxiety and mood disorders on the rise: exploring clinical profiles and risk factors

Auteurs: Artemis Gkitakou, Margreet Ten Have, Neeltje M. Batelaan, Annemarie I. Luik, Brenda W. J. H. Penninx
Publié dans: The British Journal of Psychiatry, 2025, Page(s) 1-8, ISSN 0007-1250
Éditeur: Royal College of Psychiatrists
DOI: 10.1192/bjp.2025.10454

Circulating Brain-Related miRNAs as Predictors of Postoperative Delirium in Cardiac Surgery Patients

Auteurs: Karina Nowakowska, Grzegorz Walkiewicz, Emilia Stec-Martyna, Dominika Kulczycka-Wojdala, Emilia Frankowska, Piotr Miler, Agnieszka Pawlak, Katarzyna Woźniak, Michał Krejca, Mirosław Wilczyński, Jakub Kazmierski
Publié dans: International Journal of Molecular Sciences, Numéro 26, 2025, Page(s) 9062, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26189062

Bias in O-Information Estimation

Auteurs: Johanna Gehlen, Jie Li, Cillian Hourican, Stavroula Tassi, Pashupati P. Mishra, Terho Lehtimäki, Mika Kähönen, Olli Raitakari, Jos A. Bosch, Rick Quax
Publié dans: Entropy, Numéro 26, 2025, Page(s) 837, ISSN 1099-4300
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/e26100837

Assessment of plasma ceramides as predictor for subclinical atherosclerosis

Auteurs: Pashupati P. Mishra; Binisha H. Mishra; Leo-Pekka Lyytikäinen; Mika Hilvo; Markus Juonala; Markus Juonala; Mika Kähönen; Nina Hutri-Kähönen; Dimitrios I. Fotiadis; Dimitrios I. Fotiadis; Olli T. Raitakari; Olli T. Raitakari; Reijo Laaksonen; Terho Lehtimäki
Publié dans: Atherosclerosis Plus, Numéro 1, 2021, ISSN 2667-0895
Éditeur: Elsevier BV
DOI: 10.1016/j.athplu.2021.09.005

Predicting early-stage coronary artery disease using machine learning and routine clinical biomarkers improved by augmented virtual data

Auteurs: Angela Koloi, Vasileios S Loukas, Cillian Hourican, Antonis I Sakellarios, Rick Quax, Pashupati P Mishra, Terho Lehtimäki, Olli T Raitakari, Costas Papaloukas, Jos A Bosch, Winfried März, Dimitrios I Fotiadis
Publié dans: European Heart Journal - Digital Health, Numéro 5, 2024, Page(s) 542-550, ISSN 2634-3916
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/ehjdh/ztae049

Regulation of nc886 (vtRNA2-1) RNAs is associated with cardiometabolic risk factors and diseases

Auteurs: Sonja Rajić, Thomas Delerue, Justiina Ronkainen, Ruiyuan Zhang, Joanna Ciantar, Daria Kostiniuk, Pashupati P. Mishra, Leo-Pekka Lyytikäinen, Nina Mononen, Laura Kananen, Annette Peters, Juliane Winkelmann, Marcus E. Kleber, Stefan Lorkowski, Mika Kähönen, Terho Lehtimäki, Olli Raitakari, Melanie Waldenberger, Christian Gieger, Winfried März, Emily W. Harville, Sylvain Sebert, Saara Marttila,
Publié dans: Clinical Epigenetics, Numéro 17, 2025, ISSN 1868-7083
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/s13148-025-01871-7

Genetic risk score for coronary artery calcification and its predictive ability for coronary artery disease

Auteurs: Pashupati P. Mishra, Binisha H. Mishra, Leo-Pekka Lyytikäinen, Sirkka Goebeler, Mika Martiskainen, Emma Hakamaa, Marcus E. Kleber, Graciela E. Delgado, Winfried März, Mika Kähönen, Pekka J. Karhunen, Terho Lehtimäki
Publié dans: American Journal of Preventive Cardiology, Numéro 20, 2025, Page(s) 100884, ISSN 2666-6677
Éditeur: Elsevier BV
DOI: 10.1016/j.ajpc.2024.100884

Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis

Auteurs: Chad S. Weldy, Qin Li, João P. Monteiro, Tim S. Peters, Hongchao Guo, Drew Galls, Wenduo Gu, Paul P. Cheng, Markus Ramste, Daniel Li, Brian T. Palmisano, Disha Sharma, Matthew D. Worssam, Quanyi Zhao, Amruta Bhate, Ramendra K. Kundu, Trieu Nguyen, Michal Mokry, Clint L. Miller, Sander W. van der Laan, Jin Billy Li, Thomas Quertermous
Publié dans: Nature Cardiovascular Research, Numéro 4, 2025, Page(s) 1241-1257, ISSN 2731-0590
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s44161-025-00710-5

Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci

Auteurs: Chani J. Hodonsky, Adam W. Turner, Mohammad Daud Khan, Nelson B. Barrientos, Ruben Methorst, Lijiang Ma, Nicolas G. Lopez, Jose Verdezoto Mosquera, Gaëlle Auguste, Emily Farber, Wei Feng Ma, Doris Wong, Suna Onengut-Gumuscu, Maryam Kavousi, Patricia A. Peyser, Sander W. van der Laan, Nicholas J. Leeper, Jason C. Kovacic, Johan L.M. Björkegren, Clint L. Miller
Publié dans: Cell Genomics, Numéro 4, 2024, Page(s) 100465, ISSN 2666-979X
Éditeur: Cell Press
DOI: 10.1016/j.xgen.2023.100465

Comparing Inflammatory Biomarkers in Cardiovascular Disease: Insights from the LURIC Study

Auteurs: Angela P. Moissl, Graciela E. Delgado, Hubert Scharnagl, Rüdiger Siekmeier, Bernhard K. Krämer, Daniel Duerschmied, Winfried März, Marcus E. Kleber
Publié dans: International Journal of Molecular Sciences, Numéro 26, 2025, Page(s) 7335, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26157335

Morbidity-bridging metabolic pathways: linking early cardiovascular disease risk and depression symptoms using a multi-modal approach

Auteurs: Angela Koloi, Arja Rydin, Yuri Milaneschi, Femke Lamers, Jos A Bosch, Emma Pruin, Sander W van der Laan, Pashupati P Mishra, Terho Lehtimäki, Mika Kähönen, Olli T Raitakari, Dimitrios I Fotiadis, Rick Quax
Publié dans: European Heart Journal Open, Numéro 5, 2025, ISSN 2752-4191
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/ehjopen/oeaf038

Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

Auteurs: Tanmoy Roychowdhury, Derek Klarin, Michael G. Levin, Joshua M. Spin, Yae Hyun Rhee, Alicia Deng, Colwyn A. Headley, Noah L. Tsao, Corry Gellatly, Verena Zuber, Fred Shen, Whitney E. Hornsby, Ina Holst Laursen, Shefali S. Verma, Adam E. Locke, Gudmundur Einarsson, Gudmar Thorleifsson, Sarah E. Graham, Ozan Dikilitas, Jack W. Pattee, Renae L. Judy, Ferran Pauls-Verges, Jonas B. Nielsen, Brooke N. Wo
Publié dans: Nature Genetics, Numéro 55, 2023, Page(s) 1831-1842, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1038/s41588-023-01510-y

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis

Auteurs: Jose Verdezoto Mosquera, Gaëlle Auguste, Doris Wong, Adam W. Turner, Chani J. Hodonsky, Astrid Catalina Alvarez-Yela, Yipei Song, Qi Cheng, Christian L. Lino Cardenas, Konstantinos Theofilatos, Maxime Bos, Maryam Kavousi, Patricia A. Peyser, Manuel Mayr, Jason C. Kovacic, Johan L.M. Björkegren, Rajeev Malhotra, P. Todd Stukenberg, Aloke V. Finn, Sander W. van der Laan, Chongzhi Zang, Nathan C. S
Publié dans: Cell Reports, Numéro 42, 2024, Page(s) 113380, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2023.113380

The accumulation of erythrocytes quantified and visualized by Glycophorin C in carotid atherosclerotic plaque reflects intraplaque hemorrhage and pre-procedural neurological symptoms

Auteurs: Joost M. Mekke, Tim R. Sakkers, Maarten C. Verwer, Noortje A. M. van den Dungen, Yipei Song, Clint L. Miller, Aloke V. Finn, Gerard Pasterkamp, Michal Mokry, Hester M. den Ruijter, Aryan Vink, Dominique P. V. de Kleijn, Gert J. de Borst, Saskia Haitjema, Sander W. van der Laan
Publié dans: Scientific Reports, Numéro 13, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-43369-3

The gut microbiota and depressive symptoms across ethnic groups

Auteurs: Jos A. Bosch; Max Nieuwdorp; Aeilko H. Zwinderman; Mélanie Deschasaux; Djawad Radjabzadeh; Robert Kraaij; Mark Davids; Susanne R. de Rooij; Anja Lok
Publié dans: Nature Communications, Numéro 19, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-34504-1

Major depression and atherosclerotic disease: Linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques

Auteurs: Emma Pruin, Meike Bartels, Ernest Diez Benavente, Noortje A.M. van den Dungen, Joost K.R. Hoekstra, Dominique D.P. de Kleijn, Lennart P.L. Landsmeer, Michal Mokry, Gerard Pasterkamp, Brenda W.J.H. Penninx, Wouter J. Peyrot, Hester M. den Ruijter, Sander W. van der Laan, Yuri Milaneschi
Publié dans: European Neuropsychopharmacology, Numéro 106, 2026, Page(s) 112780, ISSN 0924-977X
Éditeur: Elsevier BV
DOI: 10.1016/j.euroneuro.2026.112780

Efficient Search Algorithms for Identifying Synergistic Associations in High-Dimensional Datasets

Auteurs: Cillian Hourican, Jie Li, Pashupati P. Mishra, Terho Lehtimäki, Binisha H. Mishra, Mika Kähönen, Olli T. Raitakari, Reijo Laaksonen, Liisa Keltikangas-Järvinen, Markus Juonala, Rick Quax
Publié dans: Entropy, Numéro 26, 2025, Page(s) 968, ISSN 1099-4300
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/e26110968

BioTextQuest v2.0: An evolved tool for biomedical literature mining and concept discovery

Auteurs: Theodosios Theodosiou, Konstantinos Vrettos, Ismini Baltsavia, Fotis Baltoumas, Nikolas Papanikolaou, Andreas Ν. Antonakis, Dimitrios Mossialos, Christos A. Ouzounis, Vasilis J. Promponas, Makrina Karaglani, Ekaterini Chatzaki, Sven Brandau, Georgios A. Pavlopoulos, Evangelos Andreakos, Ioannis Iliopoulos
Publié dans: Computational and Structural Biotechnology Journal, Numéro 23, 2026, Page(s) 3247-3253, ISSN 2001-0370
Éditeur: American Association for the Advancement of Science (AAAS)
DOI: 10.1016/j.csbj.2024.08.016

Notch signaling in adipose tissue macrophages prevents diet‐induced inflammation and metabolic dysregulation

Auteurs: Eleni Siouti, Maria Salagianni, Maria Manioudaki, Eleftherios Pavlos, Apostolos Klinakis, Ioanna‐Evdokia Galani, Evangelos Andreakos
Publié dans: European Journal of Immunology, Numéro 54, 2024, ISSN 0014-2980
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202350669

Effect of tissue-grouped regulatory variants associated to type 2 diabetes in related secondary outcomes

Auteurs: Daiane Hemerich, Roelof A. J. Smit, Michael Preuss, Lauren Stalbow, Sander W. van der Laan, Folkert W. Asselbergs, Jessica van Setten, Vinicius Tragante
Publié dans: Scientific Reports, Numéro 13, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-30369-6

Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values

Auteurs: Gabin Drouard; Miina Ollikainen; Juha Mykkänen; Olli Raitakari; Terho Lehtimäki; Mika Kähönen; Pashupati P. Mishra; Xiaoling Wang; Jaakko Kaprio
Publié dans: OMICS: A journal of integrative biology, Numéro 28, 2022, ISSN 1536-2310
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/omi.2021.0201

PolarMorphism enables discovery of shared genetic variants across multiple traits from GWAS summary statistics.

Auteurs: Joanna von Berg; Michelle ten Dam; Sander W van der Laan; Jeroen de Ridder
Publié dans: Bioinformatics, Numéro 23, 2022, ISSN 1367-4803
Éditeur: Oxford University Press
DOI: 10.1101/2022.01.14.476302

Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis

Auteurs: Janne Pott, Azin Kheirkhah, Jesper R. Gadin, Marcus E. Kleber, Graciela E. Delgado, Holger Kirsten, Lukas Forer, Stefanie M. Hauck, Ralph Burkhardt, Hubert Scharnagl, Markus Loeffler, Winfried März, Joachim Thiery, Christian Gieger, Annette Peters, Angela Silveira, Ferdinand van’t Hooft, Florian Kronenberg, Markus Scholz
Publié dans: Biology of Sex Differences, Numéro 15, 2024, ISSN 2042-6410
Éditeur: BMC
DOI: 10.1186/s13293-024-00602-6

Genetically determined ancestry associates with morphological and molecular carotid plaque features

Auteurs: Nima Fahim, Tim R. Sakkers, Floor B.H. van der Zalm, Joost Hoekstra, Dominique P.V. de Kleijn, Michal Mokry, Jose Verdezoto Mosquera, Gerard Pasterkamp, Hester M. den Ruijter, Clint L. Miller, Jessica van Setten, Sander W. van der Laan
Publié dans: Atherosclerosis, Numéro 415, 2026, Page(s) 120680, ISSN 0021-9150
Éditeur: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2026.120680

Metabolomics signatures of depression: the role of symptom profiles

Auteurs: Hilde de Kluiver, Rick Jansen, Brenda W. J. H. Penninx, Erik J. Giltay, Robert A. Schoevers, Yuri Milaneschi
Publié dans: Translational Psychiatry, Numéro 13, 2023, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-023-02484-5

Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a <scp>Genome‐Wide</scp> Association <scp>Meta‐Analysis</scp> Followed by Mendelian Randomization

Auteurs: Jie Zheng, Eleanor Wheeler, Maik Pietzner, Till F. M. Andlauer, Michelle S. Yau, April E. Hartley, Ben Michael Brumpton, Humaira Rasheed, John P. Kemp, Monika Frysz, Jamie Robinson, Sjur Reppe, Vid Prijatelj, Kaare M. Gautvik, Louise Falk, Winfried Maerz, Ingrid Gergei, Patricia A. Peyser, Maryam Kavousi, Paul S. de Vries, Clint L. Miller, Maxime Bos, Sander W. van der Laan, Rajeev Malhotra, Marku
Publié dans: Arthritis & Rheumatology, Numéro 75, 2023, Page(s) 1781-1792, ISSN 2326-5191
Éditeur: Wiley & Sons
DOI: 10.1002/art.42538

Leptin and leptin receptor gene polymorphisms and depression treatment response

Auteurs: Ida-Maria Tavast, Anssi Solismaa, Leo-Pekka Lyytikäinen, Nina Mononen, Eeva Moilanen, Mari Hämäläinen, Terho Lehtimäki, Olli Kampman
Publié dans: Acta Neuropsychiatrica, Numéro 37, 2025, ISSN 0924-2708
Éditeur: Blackwell Publishing Inc.
DOI: 10.1017/neu.2024.43

How location and cellular signaling combine to activate the NLRP3 inflammasome

Auteurs: Anil Akbal; Alesja Dernst; Marta Lovotti; Matthew S. J. Mangan; Róisín M. McManus; Eicke Latz
Publié dans: Cellular and molecular immunology, Numéro 19, 2022, ISSN 1672-7681
Éditeur: Nature Publishing Group
DOI: 10.1038/s41423-022-00922-w

AI-Enhanced Predictive Modeling for Identifying Depression and Delirium in Cardiovascular Patients Scheduled for Cardiac Surgery

Auteurs: Karina Nowakowska, Antonis Sakellarios, Jakub Kaźmierski, Dimitrios I. Fotiadis, Vasileios C. Pezoulas
Publié dans: Diagnostics, Numéro 14, 2023, Page(s) 67, ISSN 2075-4418
Éditeur: MDPI
DOI: 10.3390/diagnostics14010067

An automatic entropy method to efficiently mask histology whole-slide images

Auteurs: Yipei Song, Francesco Cisternino, Joost M. Mekke, Gert J. de Borst, Dominique P. V. de Kleijn, Gerard Pasterkamp, Aryan Vink, Craig A. Glastonbury, Sander W. van der Laan, Clint L. Miller
Publié dans: Scientific Reports, Numéro 13, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-29638-1

Identification of gene networks jointly associated with depressive symptoms and cardiovascular health metrics using whole blood transcriptome in the Young Finns Study

Auteurs: Binisha H. Mishra, Emma Raitoharju, Nina Mononen, Aino Saarinen, Jorma Viikari, Markus Juonala, Nina Hutri-Kähönen, Mika Kähönen, Olli T. Raitakari, Terho Lehtimäki, Pashupati P. Mishra
Publié dans: Frontiers in Psychiatry, Numéro 15, 2024, ISSN 1664-0640
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2024.1345159

Predicting incident cardio-metabolic disease among persons with and without depressive and anxiety disorders: a machine learning approach

Auteurs: Arja O. Rydin, George Aalbers, Wessel A. van Eeden, Femke Lamers, Yuri Milaneschi, Brenda W. J. H. Penninx
Publié dans: Social Psychiatry and Psychiatric Epidemiology, Numéro 60, 2025, Page(s) 1457-1466, ISSN 0933-7954
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00127-025-02857-9

LoFTK: a framework for fully automated calculation of predicted Loss-of-Function variants

Auteurs: Folkert W. Asselbergs; Folkert W. Asselbergs; Jason H. Moore; Brendan J. Keating; A. Alasiri; A. Alasiri; S.W. Van Der Laan; Brian S. Cole; J. van Setten; Bao-Li Loza; Konrad J. Karczewski; Konrad J. Karczewski
Publié dans: BioData Mining, Numéro 15, 2023, ISSN 1756-0381
Éditeur: BioMed Central
DOI: 10.1101/2021.08.09.455694

Genetic crossroads of cardiovascular disease and its comorbidities: toward holistic therapeutic strategies

Auteurs: Binisha H. Mishra, Pashupati P. Mishra
Publié dans: BMC Medical Genomics, Numéro 19, 2026, ISSN 1755-8794
Éditeur: BioMed Central
DOI: 10.1186/s12920-025-02279-1

High genetic risk for depression as an independent risk factor for mortality in patients referred for coronary angiography

Auteurs: Robert M. Krämer, Angela P. Moissl, Stefan Lorkowski, Bernhard K. Krämer, Terho Lehtimäki, Binisha H. Mishra, Pashupati P. Mishra, Jan Leipe, Winfried März, Marcus E. Kleber, Bertram Müller-Myhsok, Graciela E. Delgado
Publié dans: Frontiers in Cardiovascular Medicine, Numéro 10, 2023, ISSN 2297-055X
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