Deliverables
Description of dominant MPSG in high risk areas (that tend to elect not to participate but which are at high risk), and of MPSG for optimisation in those who tend to participate (M6)
Biomarkers: Validation circulating miRNAValidation of two different computational models of circulating miRNAs to maximize sensitivity for risk prediction and specificity for differential diagnosis
Project Management: informed consent form- The informed consent procedures that will be implemented for the participation of humans will be explained into detail. - providing templates of the informed consent form (per country)
Biomarkers: composite risk predicting panelCombination of miRNAs, inflammatory proteins and cardio-pulmonary damage in a composite risk predicting panel.
recruitment: development tailored recruitmentIdentification of the preferred per country and most effective channels of communication and development of the tailored intervention, with different MPSG profiles, at high risk of developing lung cancer, including qualitative data on the participants’ view of the methods
Protocol: study protocol 4-IN-THE-LUNG-RUNDesign of the study protocol
Data protection: securityA description of the security measures that will be implemented to prevent unauthorised access to personal data or the equipment used for processing
Protocol: Nodule Management Strategydesign of the lung cancer nodule management protocol
Approval: study protocol - registrationi Final version of study protocol as submitted to regulatorsethics committees ii Registration number of clinical study in a WHOor ICMJE approved registry with the possibility to post resultsiii Approvals ethics committees and national competent authority if applicable required for invitationenrolment of first subject in at least one clinical centre
Data protection: privacy - anonymised/ pseudomysed dataexplain why the research data will not be anonymised/ pseudonymised
Publications
Author(s):
Kevin Haaf, Carlijn M. Aalst, Harry J. Koning, Rudolf Kaaks, Martin C. Tammemägi
Published in:
International Journal of Cancer, Issue 149/2, 2021, Page(s) 250-263, ISSN 0020-7136
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/ijc.33578
Author(s):
Carlijn M. van der Aalst, Kevin ten Haaf, Harry J. de Koning
Published in:
Translational Lung Cancer Research, Issue 10/2, 2021, Page(s) 1050-1063, ISSN 2218-6751
Publisher:
AME Publishing Company
DOI:
10.21037/tlcr-20-985
Author(s):
M. Vonder, C. van der Aalst, J. Hubert, D. Moldovanu, A. Schmitz, J.W.C. Gratama, M. Silva, H. de Koning, M. Oudkerk
Published in:
Journal of Thoracic Oncology, Issue Volume 18, Issue 11, Supplement, 2023, 2023, Page(s) Pages S218-S219, ISSN 1556-0864
Publisher:
Lippincott Williams & Wilkins Ltd.
DOI:
10.1016/j.jtho.2023.09.355
Author(s):
Koen de Nijs, Kevin ten Haaf, Carlijn van der Aalst, and Harry J. de Koning
Published in:
eClinical Medicine, Issue 2024; 102570, 2024, Page(s) 102570, ISSN 2589-5370
Publisher:
Elsevier BV
DOI:
10.1016/j.eclinm.2024.102570
Author(s):
M. Vonder, C. van der Aalst, D. Moldovanu, J. Hubert, A. Schmitz, J. Gratama, M. Silva, H. de Koning, M. Oudkerk
Published in:
Journal of Cardiovascular Computed Tomography, Issue Volume 17, Issue 4, Supplement, 2023, Page(s) S46, ISSN 1934-5925
Publisher:
Elsevier BV
DOI:
10.1016/j.jcct.2023.05.116
Author(s):
Dana Moldovanu, Harry J. de Koning, Carlijn M. van der Aalst
Published in:
Translational Lung Cancer Research, Issue 10/2, 2021, Page(s) 1099-1109, ISSN 2218-6751
Publisher:
AME Publishing Company
DOI:
10.21037/tlcr-20-899
Author(s):
C. van der Aalst, M. Vonder, J. Hubert, D. Moldovanu, A. Schmitz, S. Delorme, R. Kaaks, K. ten Haaf , M. Oudkerk, H. de Koning
Published in:
Journal of Thoracic Oncology, Issue Volume 18, Issue 11, Supplement, November 2023, 2023, Page(s) Page S217, ISSN 1556-1380
Publisher:
Elsevier
DOI:
10.1016/j.jtho.2023.09.352
Author(s):
M. Vonder, C. van der Aalst, J. Hubert, D. Moldovanu, A. Schmitz, S. Delorme, J.W. Gratama, M. Silva, H. de Koning, M. Oudkerk
Published in:
Journal of Thoracic Oncology, Issue Volume 18, Issue 11, Supplement, November 2023, 2023, Page(s) Page S172, ISSN 1556-1380
Publisher:
Elsevier
DOI:
10.1016/j.jtho.2023.09.256
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