In vivo label-free nanoscopic imaging
Recent advances in optical imaging allow a nanoscopic level of resolution with the possibility to identify individual molecules in the biosamples. Until now, high resolution of nanoscopy was achieved by labelling the biomolecules with fluorescent probes altering their property and making them sometimes improper for medical applications. The EU-funded SPECIPHIC project introduces a totally novel approach for label-free nanoscopic imaging using the optical refractive index as a molecular sensor. The project is based on the observation that phase, intensity and polarisation information can be quantitatively retrieved with unprecedented sensitivity and with an imaging resolution equivalent to regular imaging with fluorescent probes. Implementation of this technology will enable an access to nanoscopic analysis inside intact live biological samples.
Call for proposal
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