Pandemics Outbreaks Rationalized: towards a universal therapy to eliminate intracellular pathogens and drug resistance

Project Information

PANDORA

Grant agreement ID: 850936

DOI

10.3030/850936

Project closed

EC signature date 5 December 2019

Start date 1 October 2020

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 495 018,00

EU contribution

€ 1 495 018,00

Coordinated by

UNIVERSITA DEGLI STUDI DI MILANO
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (19)

Synergistic Effect Induced by Gold Nanoparticles with Polyphenols Shell during Thermal Therapy: Macrophage Inflammatory Response and Cancer Cell Death Assessment

Author(s): De Matteis, V.; Cascione, M.; Rizzello, L.; Manno, D.E.; Di Guglielmo, C.; Rinaldi, R.
Published in: Pharmaceutics, 2021, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13143610

Purification of olive mill wastewater through noble metal nanoparticle synthesis: waste safe disposal and nanomaterial impact on healthy hepatic cell mitochondria

Author(s): Valeria De Matteis, Loris Rizzello, Chiara Ingrosso & Rosaria Rinaldi
Published in: Environmental Science and Pollution Research, 2021, ISSN 0944-1344
Publisher: Springer Verlag
DOI: 10.1007/s11356-020-12267-w

Nanoenabling MbtI Inhibitors for Next-Generation Tuberculosis Therapy

Author(s): Giulia Cazzaniga, Matteo Mori, Anna Griego, Edoardo Scarpa, Giorgia Moschetti, Stefano Muzzioli, Giovanni Stelitano, Laurent R. Chiarelli, Mario Cocorullo, Emanuele Casali, Alessio Porta, Giuseppe Zanoni, Andrea Tresoldi, Elena Pini, Íris L. Batalha, Giuseppe Battaglia, Tiziano Tuccinardi, Loris Rizzello, Stefania Villa, Fiorella Meneghetti
Published in: Journal of Medicinal Chemistry, Issue 68, 2025, Page(s) 5312-5332, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c02386

Green Silver Nanoparticles Promote Inflammation Shutdown in Human Leukemic Monocytes

Author(s): Mariafrancesca Cascione,Loris Rizzello,Daniela Manno,Antonio Serra, Valeria De Matteis
Published in: Materials, 2022, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma15030775

Pre-Drawn Syringes of Comirnaty for an Efficient COVID-19 Mass Vaccination : Demonstration of Stability

Author(s): "Selmin, F.; Musazzi, U.M.; Franzè , S.; Scarpa, E.; Rizzello, L.; Procacci, P.; Minghetti, P."
Published in: Pharmaceutics, 2021, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13071029

Engineering Polymeric Nanosystems against Oral Diseases.

Author(s): Valeria Mercadante; Edoardo Scarpa; Valeria De Matteis; Loris Rizzello; Alessandro Poma
Published in: Molecules, 2021, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26082229

Tuning cell behavior with nanoparticle shape

Author(s): Edoardo Scarpa, Cesare De Pace, Adrian Steve Joseph, Senio Campos de Souza, Alessandro Poma, Eva Liatsi-Douvitsa, Claudia Contini, Valeria De Matteis, Josep Samitier Martí, Giuseppe Battaglia, Loris Rizzello
Published in: PLOS ONE, Issue 15, 2020, Page(s) e0240197, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0240197

Lipid droplet-specific NIR fluorescent probe with large Stokes shift for assessing the effect of chronic drugs on drug-induced liver injury

Author(s): Dong Wang, Wei Huang, Yaping Zhu, Yali Xie, Tao Pang, Zhihui Feng, Loris Rizzello, Xiaohe Tian, Zhongping Zhang
Published in: Sensors and Actuators B: Chemical, Issue 426, 2024, Page(s) 137089, ISSN 0925-4005
Publisher: Elsevier BV
DOI: 10.1016/j.snb.2024.137089

Nanoparticle delivery through the BBB in central nervous system tuberculosis

Author(s): Anna Griego, Edoardo Scarpa, Valeria De Matteis, Loris Rizzello
Published in: Ibrain, Issue 9, 2023, Page(s) 43-62, ISSN 2313-1934
Publisher: Wiley
DOI: 10.1002/ibra.12087

Synthesis and Assessment of the In Vitro and Ex Vivo Activity of Salicylate Synthase (Mbti) Inhibitors as New Candidates for the Treatment of Mycobacterial Infections

Author(s): Matteo Mori; Giovanni Stelitano; Anna Griego; Laurent R. Chiarelli; Giulia Cazzaniga; Arianna Gelain; Elena Pini; Marina Camera; Paola Canzano; Andrea Fumagalli; Edoardo Scarpa; Chiara Cordiglieri; Loris Rizzello; Stefania Villa; Fiorella Meneghetti
Published in: Pharmaceuticals; Volume 15; Issue 8; Pages: 992, Issue 1, 2022, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15080992

A Multiscale Study of Phosphorylcholine Driven Cellular Phenotypic Targeting

Author(s): Silvia Acosta-Gutiérrez*, Diana Matias, Milagros Avila-Olias, Virginia M. Gouveia, Edoardo Scarpa, Joe Forth, Claudia Contini, Aroa Duro-Castano, Loris Rizzello, and Giuseppe Battaglia*
Published in: ACS Central Science, 2022, ISSN 2374-7943
Publisher: ACS Central Science
DOI: 10.1021/acscentsci.2c00146

Targeting Macrophages and Synoviocytes Intracellular Milieu to Augment Anti-Inflammatory Drug Potency

Author(s): Virgínia M. Gouveia, Loris Rizzello, Bruno Vidal, Claudia Nunes, Alessandro Poma, Ciro Lopez-Vasquez, Edoardo Scarpa, Sebastian Brandner, António Oliveira, João E. Fonseca, Salette Reis, Giuseppe Battaglia
Published in: Advanced Therapeutics, 2022, ISSN 2366-3987
Publisher: Wiley Online Library
DOI: 10.1002/adtp.202270005

The multivalency game ruling the biology of immunity

Author(s): Lara Victoria Aiassa, Giuseppe Battaglia, Loris Rizzello
Published in: Biophysics Reviews, 2023, ISSN 2688-4089
Publisher: AIP Publishing
DOI: 10.26434/chemrxiv-2023-9l9dl

Hybrid Polyelectrolyte Nanocomplexes for Non-Viral Gene Delivery with Favorable Efficacy and Safety Profile

Author(s): Gabriele Maiorano; Clara Guido; Annamaria Russo; Andrea Giglio; Loris Rizzello; Mariangela Testini; Barbara Cortese; Stefania D’Amone; Giuseppe Gigli; Ilaria Elena Palamà
Published in: Pharmaceutics, Issue 1, 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071310

Time Rules the Efficacy of Immune Checkpoint Inhibitors in Photodynamic Therapy

Author(s): Qinghua Wu, Yang Chen, Qing Li, Junmeng Chen, Junfeng Mo, Ming Jin, Qianzhan Yang, Loris Rizzello, Xiaohe Tian, Lei Luo
Published in: Advanced Science, 2022, ISSN 2198-3844
Publisher: WIley Online Library
DOI: 10.1002/advs.202200999

Caffeic Acid-Grafted PLGA as a Novel Material for the Design of Fluvastatin-Eluting Nanoparticles for the Prevention of Neointimal Hyperplasia

Author(s): Stefano Bellosta, Francesca Selmin, Giulia Magri, Silvia Castiglioni, Patrizia Procacci, Patrizia Sartori, Edoardo Scarpa, Valerio Tolva, Clara Rossi, Francesco Puoci, Loris Rizzello, Francesco Cilurzo
Published in: Mol. Pharmaceutics, 2022, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.2c00693

ERα-independent NRF2-mediated immunoregulatory activity of tamoxifen

Author(s): Giovanna Pepe, Chiara Sfogliarini, Loris Rizzello, Giuseppe Battaglia, Christian Pinna, Gianenrico Rovati, Paolo Ciana, Electra Brunialti, Federica Mornata, Adriana Maggi, Massimo Locati, Elisabetta Vegeto
Published in: Biomedicine & Pharmacotherapy, 2021, ISSN 0753-3322
Publisher: Elsevier Masson
DOI: 10.1016/j.biopha.2021.112274

Targeting Macrophages and Synoviocytes Intracellular Milieu to Augment Anti‐Inflammatory Drug Potency

Author(s): Virgínia M. Gouveia, Loris Rizzello, Bruno Vidal, Claudia Nunes, Alessandro Poma, Ciro Lopez‐Vasquez, Edoardo Scarpa, Sebastian Brandner, António Oliveira, João E. Fonseca, Salette Reis, Giuseppe Battaglia
Published in: Advanced Therapeutics, Issue 5, 2025, ISSN 2366-3987
Publisher: Wiley
DOI: 10.1002/adtp.202100167

Targeting Siderophore-Mediated Iron Uptake in M. abscessus: A New Strategy to Limit the Virulence of Non-Tuberculous Mycobacteria

Author(s): Matteo Mori,Giovanni Stelitano,Giulia Cazzaniga,Arianna Gelain,Andrea Tresoldi,Mario Cocorullo, Martina Roversi, Laurent R. Chiarelli,Martina Tomaiuolo,Pietro Delre,Giuseppe F. Mangiatordi, Anna Griego, Loris Rizzello,Alberto Cassetta,Sonia Covaceuszach, Stefania Villa, and Fiorella Meneghetti
Published in: Pharmaceutics, 2023, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15020502