Pandemics Outbreaks Rationalized: towards a universal therapy to eliminate intracellular pathogens and drug resistance

Información del proyecto

PANDORA

Identificador del acuerdo de subvención: 850936

DOI

10.3030/850936

Proyecto cerrado

Fecha de la firma de la CE 5 Diciembre 2019

Fecha de inicio 1 Octubre 2020

Fecha de finalización 30 Septiembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 495 018,00

Aportación de la UE

€ 1 495 018,00

Coordinado por

UNIVERSITA DEGLI STUDI DI MILANO
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (19)

Synergistic Effect Induced by Gold Nanoparticles with Polyphenols Shell during Thermal Therapy: Macrophage Inflammatory Response and Cancer Cell Death Assessment

Autores: De Matteis, V.; Cascione, M.; Rizzello, L.; Manno, D.E.; Di Guglielmo, C.; Rinaldi, R.
Publicado en: Pharmaceutics, 2021, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13143610

Purification of olive mill wastewater through noble metal nanoparticle synthesis: waste safe disposal and nanomaterial impact on healthy hepatic cell mitochondria

Autores: Valeria De Matteis, Loris Rizzello, Chiara Ingrosso & Rosaria Rinaldi
Publicado en: Environmental Science and Pollution Research, 2021, ISSN 0944-1344
Editor: Springer Verlag
DOI: 10.1007/s11356-020-12267-w

Nanoenabling MbtI Inhibitors for Next-Generation Tuberculosis Therapy

Autores: Giulia Cazzaniga, Matteo Mori, Anna Griego, Edoardo Scarpa, Giorgia Moschetti, Stefano Muzzioli, Giovanni Stelitano, Laurent R. Chiarelli, Mario Cocorullo, Emanuele Casali, Alessio Porta, Giuseppe Zanoni, Andrea Tresoldi, Elena Pini, Íris L. Batalha, Giuseppe Battaglia, Tiziano Tuccinardi, Loris Rizzello, Stefania Villa, Fiorella Meneghetti
Publicado en: Journal of Medicinal Chemistry, Edición 68, 2025, Página(s) 5312-5332, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c02386

Green Silver Nanoparticles Promote Inflammation Shutdown in Human Leukemic Monocytes

Autores: Mariafrancesca Cascione,Loris Rizzello,Daniela Manno,Antonio Serra, Valeria De Matteis
Publicado en: Materials, 2022, ISSN 1996-1944
Editor: MDPI Open Access Publishing
DOI: 10.3390/ma15030775

Pre-Drawn Syringes of Comirnaty for an Efficient COVID-19 Mass Vaccination : Demonstration of Stability

Autores: "Selmin, F.; Musazzi, U.M.; Franzè , S.; Scarpa, E.; Rizzello, L.; Procacci, P.; Minghetti, P."
Publicado en: Pharmaceutics, 2021, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13071029

Engineering Polymeric Nanosystems against Oral Diseases.

Autores: Valeria Mercadante; Edoardo Scarpa; Valeria De Matteis; Loris Rizzello; Alessandro Poma
Publicado en: Molecules, 2021, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26082229

Tuning cell behavior with nanoparticle shape

Autores: Edoardo Scarpa, Cesare De Pace, Adrian Steve Joseph, Senio Campos de Souza, Alessandro Poma, Eva Liatsi-Douvitsa, Claudia Contini, Valeria De Matteis, Josep Samitier Martí, Giuseppe Battaglia, Loris Rizzello
Publicado en: PLOS ONE, Edición 15, 2020, Página(s) e0240197, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0240197

Lipid droplet-specific NIR fluorescent probe with large Stokes shift for assessing the effect of chronic drugs on drug-induced liver injury

Autores: Dong Wang, Wei Huang, Yaping Zhu, Yali Xie, Tao Pang, Zhihui Feng, Loris Rizzello, Xiaohe Tian, Zhongping Zhang
Publicado en: Sensors and Actuators B: Chemical, Edición 426, 2024, Página(s) 137089, ISSN 0925-4005
Editor: Elsevier BV
DOI: 10.1016/j.snb.2024.137089

Nanoparticle delivery through the BBB in central nervous system tuberculosis

Autores: Anna Griego, Edoardo Scarpa, Valeria De Matteis, Loris Rizzello
Publicado en: Ibrain, Edición 9, 2023, Página(s) 43-62, ISSN 2313-1934
Editor: Wiley
DOI: 10.1002/ibra.12087

Synthesis and Assessment of the In Vitro and Ex Vivo Activity of Salicylate Synthase (Mbti) Inhibitors as New Candidates for the Treatment of Mycobacterial Infections

Autores: Matteo Mori; Giovanni Stelitano; Anna Griego; Laurent R. Chiarelli; Giulia Cazzaniga; Arianna Gelain; Elena Pini; Marina Camera; Paola Canzano; Andrea Fumagalli; Edoardo Scarpa; Chiara Cordiglieri; Loris Rizzello; Stefania Villa; Fiorella Meneghetti
Publicado en: Pharmaceuticals; Volume 15; Edición 8; Pages: 992, Edición 1, 2022, ISSN 1424-8247
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15080992

A Multiscale Study of Phosphorylcholine Driven Cellular Phenotypic Targeting

Autores: Silvia Acosta-Gutiérrez*, Diana Matias, Milagros Avila-Olias, Virginia M. Gouveia, Edoardo Scarpa, Joe Forth, Claudia Contini, Aroa Duro-Castano, Loris Rizzello, and Giuseppe Battaglia*
Publicado en: ACS Central Science, 2022, ISSN 2374-7943
Editor: ACS Central Science
DOI: 10.1021/acscentsci.2c00146

Targeting Macrophages and Synoviocytes Intracellular Milieu to Augment Anti-Inflammatory Drug Potency

Autores: Virgínia M. Gouveia, Loris Rizzello, Bruno Vidal, Claudia Nunes, Alessandro Poma, Ciro Lopez-Vasquez, Edoardo Scarpa, Sebastian Brandner, António Oliveira, João E. Fonseca, Salette Reis, Giuseppe Battaglia
Publicado en: Advanced Therapeutics, 2022, ISSN 2366-3987
Editor: Wiley Online Library
DOI: 10.1002/adtp.202270005

The multivalency game ruling the biology of immunity

Autores: Lara Victoria Aiassa, Giuseppe Battaglia, Loris Rizzello
Publicado en: Biophysics Reviews, 2023, ISSN 2688-4089
Editor: AIP Publishing
DOI: 10.26434/chemrxiv-2023-9l9dl

Hybrid Polyelectrolyte Nanocomplexes for Non-Viral Gene Delivery with Favorable Efficacy and Safety Profile

Autores: Gabriele Maiorano; Clara Guido; Annamaria Russo; Andrea Giglio; Loris Rizzello; Mariangela Testini; Barbara Cortese; Stefania D’Amone; Giuseppe Gigli; Ilaria Elena Palamà
Publicado en: Pharmaceutics, Edición 1, 2022, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14071310

Time Rules the Efficacy of Immune Checkpoint Inhibitors in Photodynamic Therapy

Autores: Qinghua Wu, Yang Chen, Qing Li, Junmeng Chen, Junfeng Mo, Ming Jin, Qianzhan Yang, Loris Rizzello, Xiaohe Tian, Lei Luo
Publicado en: Advanced Science, 2022, ISSN 2198-3844
Editor: WIley Online Library
DOI: 10.1002/advs.202200999

Caffeic Acid-Grafted PLGA as a Novel Material for the Design of Fluvastatin-Eluting Nanoparticles for the Prevention of Neointimal Hyperplasia

Autores: Stefano Bellosta, Francesca Selmin, Giulia Magri, Silvia Castiglioni, Patrizia Procacci, Patrizia Sartori, Edoardo Scarpa, Valerio Tolva, Clara Rossi, Francesco Puoci, Loris Rizzello, Francesco Cilurzo
Publicado en: Mol. Pharmaceutics, 2022, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.2c00693

ERα-independent NRF2-mediated immunoregulatory activity of tamoxifen

Autores: Giovanna Pepe, Chiara Sfogliarini, Loris Rizzello, Giuseppe Battaglia, Christian Pinna, Gianenrico Rovati, Paolo Ciana, Electra Brunialti, Federica Mornata, Adriana Maggi, Massimo Locati, Elisabetta Vegeto
Publicado en: Biomedicine & Pharmacotherapy, 2021, ISSN 0753-3322
Editor: Elsevier Masson
DOI: 10.1016/j.biopha.2021.112274

Targeting Macrophages and Synoviocytes Intracellular Milieu to Augment Anti‐Inflammatory Drug Potency

Autores: Virgínia M. Gouveia, Loris Rizzello, Bruno Vidal, Claudia Nunes, Alessandro Poma, Ciro Lopez‐Vasquez, Edoardo Scarpa, Sebastian Brandner, António Oliveira, João E. Fonseca, Salette Reis, Giuseppe Battaglia
Publicado en: Advanced Therapeutics, Edición 5, 2025, ISSN 2366-3987
Editor: Wiley
DOI: 10.1002/adtp.202100167

Targeting Siderophore-Mediated Iron Uptake in M. abscessus: A New Strategy to Limit the Virulence of Non-Tuberculous Mycobacteria

Autores: Matteo Mori,Giovanni Stelitano,Giulia Cazzaniga,Arianna Gelain,Andrea Tresoldi,Mario Cocorullo, Martina Roversi, Laurent R. Chiarelli,Martina Tomaiuolo,Pietro Delre,Giuseppe F. Mangiatordi, Anna Griego, Loris Rizzello,Alberto Cassetta,Sonia Covaceuszach, Stefania Villa, and Fiorella Meneghetti
Publicado en: Pharmaceutics, 2023, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15020502